supported by National Natural Science Foundation of China(No.81102557);Doctoral Program Foundation of Higher Education of China(No.20104323110001);Aid Project for Innovation Platform Open Fund of Hunan province university(No.11K050);General Project of Education Bureau of Hunan Province(No.11C0963);Key Project of Administration of traditional Chinese Medicine of Hunan province(No.201301);Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province