期刊论文

中文

中国中医急症

1004-745X

2018

27

4

625-627

10.3969/j.issn.1004-745X.2018.04.018

湖南中医药大学中医诊断学国家重点学科开放基金（2014-17）；

本校为第一机构

目的 探讨痛风性关节炎中医证型与患者血清中白介素-1β(IL-1β)、白介素-6(IL-6),肿瘤坏死因子-α(TNF-α)之间的关系.方法 选取痛风性关节炎患者216例(湿热蕴结证80例,湿热夹瘀证56例,痰瘀阻滞证57例,肝肾亏虚证23例),正常对照组40例,检测两组人群血清中的IL-1β、IL-6及TNF-α水平.结果 痛风性关节炎患者组血清中IL-1β、IL-6、TNF-α阳性率及检测值均明显高于正常对照组.各中医证型间患者血清中IL-1β、IL-6及TNF-α阳性率差异无统计学意义(P＞0.05).湿热蕴结证与湿热夹瘀证患者血清中IL-1β、IL-6、TNF-α的检测值均明显高于其他两证,其中以湿热蕴结证为最高(均P＜ 0.05).结论 痛风性关节炎...

Objective： To investigate the relationship between the TCM syndrome of gouty arthritis and IL-1β,IL-6,TNF-α in patients. Methods： A total of 216 cases of patients with gouty arthritis were selected（80 cases of dampness and heat,56 cases of damp heat with blood stasis syndrome,57 cases of phlegm and blood stasis type,23 cases of liver and kidney deficiency type）,40 cases as the normal control group. Serum levels of IL-1β,IL-6 and TNF-α were detected. Results： 1）The positive rate and detection value of serum IL-1β,IL-6 and TNF-αwere s...