期刊论文

Deng Le

英文

Biochemical and Biophysical Research Communications

0006-291X

2017

483

2

847-854

10.1016/j.bbrc.2017.01.016

National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81271660]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2014JJ7062]; Specialized Research Fund from the Ministry of Education for the Doctoral Program of Higher Education [20114306110006]

本校为其他机构

Biofilm formation involves the development of extracellular matrix and initially depends on adherence and tropism by flagellar movement. With the widespread development of antibiotic resistance and tolerance of biofilms, there is a growing need for novel anti-infective strategies. No currently approved medications specifically target biofilms. Aptamers are single-stranded nucleic acid molecules that may bind to their targets with high affinity and affect the target functions. We developed a bifunctional conjugate by linking an aptamer targeting...