Oral leukoplakia refers to occur on the oral mueosa damage that gives priority to with white,can't with clinical and histopathological diagnosis of any other disease, WHO has taken it as a precancerous lesion. Oral leukoderma due to complex and pathogenesis is not clear, now without specific treatment. In recent 10 years,in the clinical treatment and prevention and treatment of oral leukoplakia canceration study found that Chinese medicine has a unique advantage. In this paper, the heterog...