Serum levels of HSP70 and other DAMP proteins can aid in patient diagnosis after traumatic injury

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ren, Biqiong*（任碧琼）;Zou, Guoying;Huang, Yiran;Xu, Guofeng;Xu, Fei;...

通讯作者：

Ren, Biqiong（任碧琼）

作者机构：

[Ren, Biqiong; He, Junyu; Zhu, Haowen; Zou, Guoying; Xu, Guofeng; Xu, Fei] Hunan Prov Second Peoples Hosp, Clin Lab, 427 Furong Rd Changsha, Changsha 410007, Hunan, Peoples R China.

[Ren, Biqiong; He, Junyu; Zhu, Haowen; Zou, Guoying; Huang, Yiran; Xu, Guofeng; Xu, Fei] Hunan Univ Chinese Med, Sch Clin Med, Changsha 410007, Hunan, Peoples R China.

[Ren, Biqiong; He, Junyu; Zou, Guoying; Yu, Ping] Cent South Univ, Sch Basic Med, Dept Immunol, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Ren, Biqiong] H

[Ren, Biqiong] C

Hunan Prov Second Peoples Hosp, Clin Lab, 427 Furong Rd Changsha, Changsha 410007, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Clin Med, Changsha 410007, Hunan, Peoples R China.

Cent South Univ, Sch Basic Med, Dept Immunol, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

Biomarkers;DAMPs;Diagnosis;HSP70;Infection;Trauma

期刊：

Cell Stress & Chaperones

ISSN：

1355-8145

年：

2016

卷：

期：

页码：

677-686

DOI：

10.1007/s12192-016-0694-4

基金类别：

This work was supported by a research grant from the Health Department of Hunan Province Foundation.

机构署名：

本校为通讯机构

院系归属：

临床医学院

摘要：

Danger-associated molecular patterns (DAMPs) are activated by endogenous signals that originate from stressed, injured, or necrotic cells, signifying “danger” to the host. In this study, we evaluated the expression of the DAMP heat shock protein 70 (HSP70) in trauma patients with and without secondary infections. Levels of glucose (GLU), procalcitonin (PCT), total cholesterol (T-Chol), and white blood cell (WBC) counts were also evaluated at three time stages after trauma. Our analysis showed that the levels of serum HSP70 in patients with mi...

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Serum levels of HSP70 and other DAMP proteins can aid in patient diagnosis after traumatic injury

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