MicroRNA-34a Suppresses Autophagy in Alveolar Type II Epithelial Cells in Acute Lung Injury by Inhibiting FoxO3 Expression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Song, Lan（宋岚）;Zhou, Fangliang（周芳亮）;Cheng, Lijuan（程莉娟）;Hu, Mei（胡梅）;He, Yingchun（何迎春）;...

通讯作者：

Liao, Duanfang;Xu, Zhaojun

作者机构：

[Cheng, Lijuan; Zhou, Fangliang; Hu, Mei; Zhang, Bo; Song, Lan; He, Yingchun] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, 300 Xueshi Rd,Hanpu Sci & Teaching Pk, Changsha 410208, Hunan, Peoples R China.

[Zhou, Fangliang; Song, Lan; Liao, Duanfang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, 300 Xueshi Rd,Hanpu Sci & Teaching Pk, Changsha 410208, Hunan, Peoples R China.

[Xu, Zhaojun] Hunan Univ Chinese Med, Affiliated Hosp 1, Cardiothorac Surg, 97 Shaoshan Rd, Changsha 41007, Hunan, Peoples R China.

通讯机构：

[Liao, Duanfang; Xu, Zhaojun] H

Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, 300 Xueshi Rd,Hanpu Sci & Teaching Pk, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Affiliated Hosp 1, Cardiothorac Surg, 97 Shaoshan Rd, Changsha 41007, Hunan, Peoples R China.

语种：

英文

关键词：

FoxO3;acute lung injury;alveolar type II epithelial cells;autophagy;miR-34a

期刊：

Inflammation

ISSN：

0360-3997

年：

2017

卷：

期：

页码：

927-936

DOI：

10.1007/s10753-017-0537-1

基金类别：

Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2014JJ7062]; Research Foundation of Traditional Chinese medicine of Hunan Province, China [201696]; Open Research Foundation of Key Laboratory of traditional Chinese medicine in Hunan, Hunan University of Chinese Medicine China [ZYNK201506]; Research Foundation of Education Bureau of Hunan Province, China [13C691]; 58 batch Postdoctoral Science Foundation, China [2015M580690]; Research Foundation of Stem Cell Regulation and Application, Hunan University of Chinese Medicine, China [2013GXB02]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

中医学院

第一中医临床学院

药学院

摘要：

Excessive autophagic activity of alveolar type II epithelial (AT-II) cells is one of the main causes of acute lung injury (ALI); however, the underlying molecular mechanism remains to be determined. The microRNAs (miRNAs) are involved with autophagy in many diseases. The objective of this study was therefore to investigate the relationship between the miRNA expression and the autophagic activity of the AT-II cells in the pathogenesis of ALI and its molecular mechanism. A mouse model of ALI and AT-II cell injury was induced using lipopolysacchar...

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MicroRNA-34a Suppresses Autophagy in Alveolar Type II Epithelial Cells in Acute Lung Injury by Inhibiting FoxO3 Expression

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