期刊论文

Study on the anti-influenza effect of Maxing Shigan Decoction combined with oseltamivir on A virus

中文

中华中医药杂志

1673-1727

2017

32

9

4163-4167

国家自然科学基金项目(No.81473468,No.81503445) 湖南省自然科学基金项目(No.13JJ6062,No.2016JJ2095) 湖南省教育厅项目(No.17K067,No.13A066,No.15C1032) 湖南省卫生计生委科研课题(No.C2015-16,No.C2016049) 湖南省高校科技创新团队《感染性疾病中医药防治研究》资助项目(No.15) 湖南省研究生创新性实验项目(No.CX2015B325) 湖南中医药大学重点学科《基础医学》、《病原生物学》资助项目(No.1)~~

本校为第一机构

目的:探讨麻杏石甘汤与奥司他韦联合用药抗A型流感病毒的实验效应。方法:①以血清药理学实验技术检测联合用药的含药血清体外对流感病毒感染MDCK细胞活性和流感病毒神经氨酸酶(NA)活性的影响。②以整体动物实验技术检测联合用药体内对流感病毒感染小鼠体质量、肺指数、肺组织病理变化的影响。结果:①各含药血清组MDCK细胞活性OD值较病毒对照组显著升高(P

Objective: To explore theanti-influenza effect of Maxing Shigan Decoction combined with oseltamivir on A virus. Methods: ①The effects of drug containing serum on MDCK cell activity and influenza virus neuraminidase (NA) activity in vitro was detected by serum pharmacological assay. ②The effects of intrauterine infection on the body weight, lung index and pathological changes of lungs in mice infected with influenza virus were detected by whole animal experiment. Results: ①Compared with the virus control group, the containing serum groups MDC...