Objective: To investigate the effects of anti-influenza virus by using Maxing Shigan Decoction (MXSGD) with different proportions of composition. Methods: Sixteen combinations were developed by orthogonal test in 2 levels of 4 factors. And control (A) group, model (B) group, Oseltamivir (C)group and Maxing Shigan Decoction group were set. The indexes were detected after giving corresponding treatment. Results: Compared with A group, the body weight of the mice infected with influenza virus decreased significantly, and the lung index increased significantly (P