Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ren, Biqiong*（任碧琼）;Luo, Shudi;Tian, Xuefei（田雪飞）;Jiang, Zhichao;Zou, Guoying;...

通讯作者：

Ren, Biqiong（任碧琼）

作者机构：

[Tian, Xuefei; Ren, Biqiong; Zou, Guoying; Jiang, Zhichao; Yin, Tieqiu; Xu, Fei] Hunan Univ Chinese Med, Peoples Hosp Hunan Prov 2, Clin Lab, 427 Furong Rd, Changsha 410007, Hunan, Peoples R China.

[Tian, Xuefei; Ren, Biqiong; Zou, Guoying; Huang, Yiran; Liu, Junlong; Jiang, Zhichao; Yin, Tieqiu; Luo, Shudi; Xu, Fei] Hunan Univ Chinese Med, Clin Med Coll, Dept Clin Lab Med, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Ren, Biqiong] H

Hunan Univ Chinese Med, Peoples Hosp Hunan Prov 2, Clin Lab, 427 Furong Rd, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

liver cancer;HepG2;eHSP70;TLR4;curcumin

期刊：

Oncology Reports

ISSN：

1021-335X

年：

2018

卷：

期：

页码：

895-901

DOI：

10.3892/or.2018.6485

基金类别：

Hunan Administration of Traditional Chinese Medicine Key Fund [201720]

机构署名：

本校为第一且通讯机构

院系归属：

临床医学院

摘要：

Curcumin has been revealed to inhibit liver cancer, however, no studies have reported that the mechanism of curcumin's action on liver cancer is related to damage-associated molecular pattern (DAMP) molecules heat shock protein 70 (HSP70) and the toll-like receptor 4 (TLR4) signaling. This study aimed to investigate whether the activation of TLR4 signaling by HSP70 could be inhibited by curcumin, thus investigating the possible mechanism of curcumin in the inhibition of liver cancer. Western blotting was used to evaluate the expression of the HSP70 and TLR4 in HepG2 cells and ELISA was used to...

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Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling

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