期刊论文

中文

湖南中医药大学学报

1674-070X

2016

36

9

26-28

10.3969/j.issn.1674-070X.2016.09.006

湖南省教育厅重点项目资助（12A101）； 湖南中医药大学中医临床基础重点学科资助;湖南中医药大学校级青年基金（校行科字[2013]4号）资助；

本校为第一机构

目的探讨清热解毒化浊片对内毒素血症（Endotoxemia,ETM）模型兔肝功能、肝组织CD14和血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）的影响。方法将21只新西兰大耳白兔随机分为正常组、模型组、清热解毒化浊片组（清化组）,每组7只。将模型组及清化组兔沿耳缘静脉注射大肠杆菌内毒素（LPS,10μg/kg）,于造模后2 h干预,灌胃后2 h心脏采血检测家兔的肝功能、TNF-α和IL-α的变化,采肝脏组织检测CD14及观察肝脏病理形态。结果 （1）与模型组比较,清化组ALT、AST上升（P〈0.05）,肝组织CD14表达及血清TNF-α、IL-1下降（P〈0.05）;（2）模型组肝细胞排列结构紊乱,有炎性细胞浸润,且出现空泡...

Objective To investigate the effect of Qingre Jiedu Huazhuo (QJH) tablets on the expression of CD14, TNF-α and IL-1 in liver tissue of ETM rabbits. Methods The 21 New Zealand big-eared rabbits were randomly divided into normal group, model group, QJH tablets group, 7 in each group. The ear edge of model group and QJH group was given intravenous injection of 10 μg/kg endotoxin. After 2 hours of modeling, the rabbites were given intervention. Then, the liver function, TNF-α and IL-1 were tested. The CD14 in liver tissue was determined and the ...