期刊论文

Effects of YTT on mRNA Expression of C-myc and PDGF-A in the Patients with IRS

中文

中西医结合心脑血管病杂志

1672-1349

2003

1

8

442-444

10.3969/j.issn.1672-1349.2003.08.005

湖南省教育厅重点项目 （No.99A0 3）；

本校为第一机构

目的:探讨养心通脉片防治胰岛素抵抗综合征(IRS)的分子生物学机制,主要是检测分析该药对IRS病人外周血单核细胞C-myc基因和血小板衍化生长因子-A(PDGF-A) mRNA表达水平的影响.方法:设养心通脉片组(33例)、二甲双胍片组(34例).两组病例分别于服药前、服药后的第10天采空腹血液,用常规方法定量检测血糖(FPG);用放射免疫法检测血胰岛素(FINS);用半定量RT-PCR法检测外周血单核细胞C-myc基因和PDGF-A mRNA的表达水平.结果:养心通脉片组病人服药后FPG、FINS含量与服药前比较明显下降(P＜0.01),胰岛素敏感指数(ISI)与服药前比较明显上升(P＜0.01);养心通脉片组病人服药后外周血单核细胞C-myc基因、PDGF...

Objective:To explore the molecular mechanism of Yangxin Tongmai Tablet (YTT) in preventive and curative insulin resistance syndrome (IRS) through checking the effects of YTT on mRNA of C-myc and platelet derived growth factor-A (PDGF-A) in unit-nuclear cell of peripheral circulation. Methods:77 cases with IRS patients were randomly divided into 2 groups, viz. 33 and 44 cases treated with YTT and metformin (met), respectively. Fasting plasma glucose (FPG) and insulin(FINS), etc. were measured by the conventional method, while the expression level of mRNA of C-myc and PDGF-A was tested with the ...