期刊论文

中文

中国现代医学杂志

1005-8982

2006

16

11

1651-1653,1656

10.3969/j.issn.1005-8982.2006.11.015

本校为其他机构

目的 比较莪术及莪术配伍柴芍六君子汤后治疗大鼠肝硬化的疗效和副作用。方法 运用牛血清白蛋白（BSA）致大鼠免疫性肝硬化模型，应用不同剂量和不同疗程的莪术和莪术＋柴芍六君子汤治疗，分别在用药20和40d时处死大鼠，运用超速离心法分离线粒体。检测肝细胞线粒体还原性谷胱甘肽（GSH）、Na^＋-K^＋-ATP酶、Ca^2＋-ATP酶、Ca^2＋含量。结果 莪术能够促使肝细胞线粒体的钙超载，降低其ATP酶的活性，大剂量的莪术能够诱导线粒体内的脂质过氧化反应，增加脂质过氧化产物。同时，莪术还可以降低Bcl-2在肝细胞上的表达量；柴芍六君子汤可以在一定程度上拮抗莪术对肝细胞线粒体的损伤（以ATP酶升高及...

[Objective] To investigate the effects and side effects of Rhizoma Zedoariae or Rhizoma Zedoariae in combination with Chaishao Liujunzi Decoction in the treatment of cirrhosis of liver in rats. [Methods] The models of cirrhosis of liver in rats were established by injection with bovine serum albumin（BSA）. The rats were treated with Rhizoma Zedoariae or Rhizoma Zedoariae in combination with Chaishao Liujunzi Decoction with different dosage and courses of treatment, and the rats were put to death 20 and 40 days respectively after the medication...