Objective To explore the mechanism of combination of Astragaloside IV and Panax notoginseng active ingredient against cerebral ischemia-reperfusion injury. Methods C57 BL /6 mice were randomly divided into: sham,model,Astragaloside Ⅳ( AST Ⅳ),Ginsenoside Rg1( Rg1),Ginsenoside Rb1( Rb1),Notoginsenoside R1( R1),four active components combination,AST Ⅳ + Rg1,AST Ⅳ + Rb1,AST Ⅳ + R1 and Edaravone,pretreated for 3 d.After 1 h of the last administration,the model of cerebral ischemic-reperfusion injury was established by bilateral comm...