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Atractylodes macrocephala Koidz stimulates intestinal epithelial cell migration through a polyamine dependent mechanism

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成果类型:
期刊论文
作者:
Song, Hou-Pan(宋厚盼);Li, Ru-Liu;Zhou, Chi;Cai, Xiong(蔡雄);Huang, Hui-Yong(黄惠勇
通讯作者:
Song, HP
作者机构:
[Song, Hou-Pan; Cai, Xiong; Huang, Hui-Yong] Hunan Univ Chinese Med, Inst TCM Diagnost, Changsha 410208, Hunan, Peoples R China.
[Song, Hou-Pan; Li, Ru-Liu] Guangzhou Univ Chinese Med, Spleen & Stomach Inst, Guangzhou 510405, Guangdong, Peoples R China.
[Zhou, Chi] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Guangdong, Peoples R China.
[Song, HP] Hunan Univ Chinese Med, Inst TCM Diagnost, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Song, HP ] H
Hunan Univ Chinese Med, Inst TCM Diagnost, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
Atractylodes macrocephala extract;beta actin;eflornithine;gastrointestinal agent;messenger RNA;myosin II;polyamine;protein Cdc42;Rac1 protein;Rho factor;RhoA guanine nucleotide binding protein;spermidine;messenger RNA;myosin II;plant extract;polyamine;Rho guanine nucleotide binding protein;animal cell;Article;Asteraceae;Atractylodes macrocephala;cell culture;cell membrane;cell migration;cell migration assay;comparative study;confocal microscopy;controlled study;cytoplasm;drug efficacy;drug mechanism;high performance liquid chromatography;immunohistochemistry;intestine epithelium cell;nonhuman;protein expression;rat;real time polymerase chain reaction;reverse transcription polymerase chain reaction;stress fiber;Western blotting;wound;animal;Atractylodes;cell line;cell motion;Chinese medicine;drug effects;epithelium cell;genetics;metabolism;physiology;wound healing;Atractylodes macrocephala;Animals;Atractylodes;Cell Line;Cell Movement;Epithelial Cells;Medicine, Chinese Traditional;Myosin Type II;Plant Extracts;Polyamines;Rats;rho GTP-Binding Proteins;RNA, Messenger;Wound Healing
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2015
卷:
159
页码:
23-35
基金类别:
the National Natural Science Foundation of China#&#&#81173254 Key S&R Program of Hunan Department of S&T#&#&#2012TF-1005
机构署名:
本校为第一且通讯机构
院系归属:
中医学院
摘要:
Ethnopharmacological relevance: Atractylodes macrocephala Koidz (AMK), a valuable traditional Chinese herbal medicine, has been widely used in clinical practice for treating patients with disorders of the digestive system. AMK has shown noteworthy promoting effect on improving gastrointestinal function and immunity, which might represent a promising candidate for the treatment of intestinal mucosa injury. The aim of this study was to investigate the efficacy of AMK on intestinal mucosal restitution and the underlying mechanisms via intestinal e...

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