期刊论文

中文

激光生物学报

1007-7146

2014

23

5

385-389

10.3969/j.issn.1007-7146.2014.05.001

干细胞中药调控与应用实验室开放基金项目（2013GXB01） 湖南中医药大学博士启动基金干细胞中药调控与应用实验室开放基金项目（2013GXB02） 国家自然科学基金项目（81273988）

本校为其他机构

肿瘤干细胞(Cancer stem cells, CSCs)是肿瘤组织中一小部分具有自我更新和致瘤性的细胞, 具有特殊的耐药机制, 与肿瘤的复发和治疗失败关系密切。微小RNA(microRNAs, miRNAs)是一类长度约为19~25个核苷酸的内源性非编码单链RNA, 能够通过调控相关靶基因的表达, 参与调控肿瘤干细胞增殖、凋亡、上皮-间质转化等重要的生命过程, 引起CSCs对化疗药物产生原发性多药耐药性。本论文就miRNAs在调控CSCs多药耐药性方面的研究进展作一综述。 Cancer stem cells(CSCs) are a subpopulation of tumor cells that possess self-renewal to regenerate themselves and tumor initiation capacity. CSCs pos...

Cancer stem cells （CSCs） are a subpopulation of tumor cells that possess self-renewal to regenerate them- selves and tumor initiation capacity. CSCs possess special intrinsic Inechanisins of resistance to chemotherapeutic drugs, leading to cancer recurrence and treatment failure. MicroRNAs （ IniRNAs ） are short endogenous non-coding single- stranded RNAs that consist of 21 to 25 nucleotides. They play important roles in several cellular processes of CSCs by regulating the expression of related target genes, such as proliferation, apoptosis,...