Osteoarthritis is a kind of chronic degenerative disease with a pathological feature of articular cartilage degeneration and bone hyperplasia around the arthrosis. Studies have demonstrated that chondrocyte apoptosis plays a critical role in the pathology occurrence and progress of osteoarthritis, making it a potential target for the treatment of osteoarthritis, This paper reviewed the chondrocyte apoptosis-related three signal transduction pathways and therapies of osteoarthritis using traditional Chinese medicine which targets the osteoarthritis-related apoptosis molecules, providing a theor...