期刊论文

Relevant Research of ACE Gene Single Nucleotide Polymorphism and Blood Stasis Syndrome of Premature Coronary Heart Disease

中文

辽宁中医杂志

1000-1719

2015

42

6

1155-1158

10.13192/j.issn.1000-1719.2015.06.002

81001518:国家自然科学基金 81373550:国家自然科学基金 81202647:国家自然科学基金 131042:霍英东教育基金 2012M521526:中国博士后科学基金 2013T60771:中国博士后科学基金 2013ZYZD28:创新基金

本校为第一机构

目的:探讨肌细胞增强因子2A（Myocyte Enhancer Factor 2a,MEF2A）基因单核苷酸多态性（SNP）与早发冠心病血瘀证的相关性。方法:从MEF2A基因选取2个SNP位点rs2033547和rs34851361,建立基于飞行时间质谱分析技术（TOF-MS）的方法,对收集的早发CHD血瘀证组21例,早发CHD非血瘀组30例,非"早发冠心病"血瘀组25例与健康对照组20例,检测各SNP位点的等位基因和基因分型,对比各组等位基因和各基因型频率,并比较各临床资料。结果:rs2033547、rs34851361都有A和T两种等位基因,包括AA、TT、AT 3种基因型;MEF2A基因多态性位点rs2033547的A等位基因在早发CHD血瘀证组,早发CHD非血瘀证组和非"早发CHD"血瘀证组...

Objective：To investigate the relationship between the Myocyte Enhancer Factor. 2a（ MEF2A ）gene single nucleo-tide polymorphism and the blood stasis syndrome of premature coronary heart disease （PCHD）. Methods：Choose two SNPs rs2033547and rs34851361 in the MEF2A gene,detecting the SNPs of 21 cases in the group of blood- stasis syndrome of PCHD, 30 cases in the group of non - blood - stasis syndrome of PCHD ,25 cases in the group of blood - stasis syndrome of non - PCHD and 20 cases in the control group base on the technology of the time of...