期刊论文

Yao, X.-L.

中文

中华眼科杂志

0412-4081

2008

44

11

1011-1019

10.3321/j.issn:0412-4081.2008.11.012

国家自然科学基金资助项目（30772824） 湖南省自然科学基金资助项目（07JJ3049）

本校为第一且通讯机构

目的 观察密蒙花提取物对雄兔去势所致干眼症的预防作用,探讨密蒙花提取物抗雄激素水平下降所致干眼症的机制.方法 实验研究.将30只日本大耳白雄兔随机分为空白组(A)、模型组(B)、治疗组(C、D、E),每组6只,对B、C、D、E组行去势术建立动物模型,对C、D、E组分别以密蒙花提取物1倍剂量和2倍剂量以及染料木黄酮连续灌胃1个月,对全部实验兔行Schirmer Ⅰ试验,对兔泪腺组织中炎性因子转化生长因子(TGF)-β1、白细胞介素(IL)-1β、肿瘤坏死因子(TNF)·α和凋亡相关基因蛋白Fas、FasL、Bax、bcl-2进行检测,电镜观察显微结构变化.各组SIT测量值治疗前后比较,使用配对t检验,如不满足t检验的使用条件则使用...

Objective: To assess the preventive effects of extract of buddleja officinalis on dry eye in castrated rabbits and to discuss the mechanism of these effects. Methods: It was a experimental study. Thirty male rabbits were divided equally into normal group (A), disease group (B) and treatment group (C, D, and E). The dry eye model was established with orchiectomy (ORX) in Group B, C, D and E. Group C, D and E were gastrically perfused with single-dose or double-does of buddleja officinalis extract or genistein for 30 days. All rabbits were examin...