Total saponins of Panax Notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion

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成果类型：

期刊论文

作者：

Li, Hua（李花）;Deng, Chang-Qing（邓常清）;Chen, Bei-Yang;Zhang, Shu-Ping;Liang, Yan;...

通讯作者：

Deng, CQ

作者机构：

[Li, Hua; Chen, Bei-Yang] Hunan Univ Tradit Chinese Med, Dept Histol & Embryol, Changsha, Hunan, Peoples R China.

[Deng, Chang-Qing; Zhang, Shu-Ping; Liang, Yan] Hunan Univ Tradit Chinese Med, Lab Pathophysiol, Changsha, Hunan, Peoples R China.

[Li, Hua; Luo, Xue-Gang] Cent S Univ, Xiangya Sch Med, Dept Anat & Neurobiol, Changsha, Hunan, Peoples R China.

通讯机构：

[Deng, CQ ] H

Hunan Univ Tradit Chinese Med, Lab Pathophysiol, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

apoptosis inhibitor;caspase;caspase 3;caspase 8;interleukin 1beta converting enzyme;Panax notoginseng extract;saponin derivative;animal experiment;animal model;animal tissue;apoptosis;article;brain infarction;brain ischemia;Chinese medicine;controlled study;drug effect;drug efficacy;drug isolation;enzyme inhibition;experimental model;female;male;middle cerebral artery occlusion;neuroprotection;nick end labeling;nonhuman;Panax notoginseng;protein expression;rat;regulatory mechanism;reperfusion;Animals;Apoptosis;Brain;Brain Ischemia;Caspases;Female;Infarction, Middle Cerebral Artery;Male;Nimodipine;Panax notoginseng;Phytotherapy;Plant Extracts;Random Allocation;Rats;Rats, Sprague-Dawley;Reperfusion Injury;Saponins;Vasodilator Agents;Panax notoginseng;Rattus

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2009

卷：

121

期：

页码：

412-418

DOI：

10.1016/j.jep.2008.10.042

基金类别：

This study was supported by a grant from National Nature Science Foundation of China (No. 30171132).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

中医学院

摘要：

Ethnopharmacological relevance: Total saponins of Panax notoginseng (TSPN), main constituents extracted from Panax Notoginseng, a highly valued traditional Chinese medicine, have been shown to be an effective agent on cerebral infarction. Aim of the study: The effects of TSPN on apoptosis and expressions of caspase-1, caspase-3 and caspase-8 were studied after cerebral ischemia for 2 h followed by reperfusion for 46 h in rats. Materials and methods: Rats were subjected to transient middle cerebral artery occlusion (MCAO) model using the intralu...

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Total saponins of Panax Notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion

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