期刊论文

Experimental Study on Effect of Maxingshigan Dectoctin on Anti influenza Virus A in Vitro

中文

实用预防医学

1006-3110

2007

14

5

1351-1353

10.3969/j.issn.1006-3110.2007.05.008

湖南省自然基金资助项目（项目批准号:06JJ20055）；

本校为其他机构

目的 研究麻杏石甘汤体外抗A型流感病毒的作用.方法 运用鸡胚培养法和微量血凝试验检测麻杏石甘汤对A型流感病毒增殖的抑制作用;运用细胞培养技术和MTT法检测麻杏石甘汤对A型流感病毒感染的宿主细胞活性的影响.结果 在治疗给药和预防给药两种方式中,麻杏石甘汤在250、125 mg/ml时对鸡胚中流感病毒的血凝滴度的抑制倍数在4以上.在这两种给药方式中,麻杏石甘汤对A型流感病毒感染的MDCK细胞的治疗指数(TI)分别为2.78、1.71.结论 麻杏石甘汤能通过抑制病毒增殖和保护宿主细胞而发挥较强的抗流感病毒作用.

Objective To investigate the inhibitory effects of Maxingshigan dectoctin（MXSGD） on influenza virus A and its＇ protective effects on host＇s cells in vitro. Methods The chicken embryo culture test and the hemagglutination reaction were used to determine the inhibitory effects of MXSGD on influenza virus A proliferation. The cell culture technique and MTT test were used to determine the effects of MXSGD on MDOK cells activities infected by influenza virus A. Results The inhibitory multiple of MXSGD on the hemagglutination titer of influenza v...