期刊论文

Peng, Q.-H.

中文

国际眼科杂志：英文版

2222-3959

2009

9

7

1248-1251

10.3969/j.issn.1672-5123.2009.07.010

中国国家自然科学基金资助项目（No.30772824）； 中国教育部博士学科点专项科研基金项目（No.200805410004）； 中国湖南省自然科学基金项目（No.07JJ3049）~~；

本校为第一且通讯机构

目的:探讨密蒙花总黄酮对去势雄鼠干眼症动物模型角膜及泪腺组织炎症因子表达的影响与组织损伤的关系.方法:选取150只健康1月龄Wistar雄性大鼠随机分为5组(正常组、假手术组、手术对照组、雄激素治疗组、密蒙花总黄酮治疗组,分别用A,B,C,D,E组表示),每组30只.将C,D,E三组实验鼠切除双侧睾丸及附睾;B组只切开阴囊,不切除睾丸,作为假手术对照组,A组不作处理.自造模后1wk,待伤口基本愈合开始用药.A,B,C组以生理盐水灌胃,1次/d;D组用丙酸睾酮注射液大腿肌肉注射, 3d 1次;E组以密蒙花提取物生理盐水混悬液灌胃,1次/d.各组实验动物分别于用药1,3,5mo后随机取10只,行Schirmer Ⅰ试验、泪膜破裂时间(bre...

•AIM: To assess the relationships between the inflammatory factors and tissue injury in cornea and lacrimal gland of castrated rat eye models by intervention of buddlija offcinalis flavone. • METHODS: One hundred and fifty healthy Wistar rats were divided randomly into 5 groups each with 30 rats: the normal group (A); the false operation group (B); the model (castrated) group (C); the therapy group treated with testosterone (D); the therapy group with buddleja offcinalis flavone (E). Bilateral testis and epididymis of group C, D and E were re...