期刊论文

中文

中国药理学通报

1001-1978

2013

29

12

1762-1765

10.3969/j.issn.1001-1978.2013.12.031

基金项目：湖南中医药大学中医诊断学国家重点学科开放基金项目（No2013ZYZD10） 湖南省研究生科研创新项目（NoCX20128348）

本校为第一机构

目的 建立一个操作简单、检测快速和结果准确可靠的可广泛用于小动物实验研究的血沉(erythrocyte sedimentation rate,ESR)测定方法.方法 以大鼠佐剂型关节炎模型(adjuvant-induced arthritis,AIA)为研究对象,对应用微量毛细管倾斜法进行血沉测定的两个主要变量倾斜角度和测定时间进行优选.结果 微量毛细管倾斜角度对血沉的升高影响明显,血沉值由小到大顺序依次为90°

Aim: To establish a simple, rapid, and accurate method for determination of erythrocyte sedimentation rate (ESR) by using capillary tubes in in vivo experimental models. Methods: Adjuvant-induced arthritis (AIA) was established in male Sprague-Dawley (SD) rats, and blood specimens were collected from the veins of the tails of AIA and control rats for determination of ESR using the Westegren or capillary tubes. Different angles of incline of the capillary tubes and durations of ESR determination were screened. Results: The angle of incline of th...