期刊：
ICIC 2009: SECOND INTERNATIONAL CONFERENCE ON INFORMATION AND COMPUTING SCIENCE, VOL 1, PROCEEDINGS: COMPUTING SCIENCE AND ITS APPLICATION,2009年:39-41
通讯作者：
Yan, Jun-Feng
作者机构：
[Yan, Jun-Feng; Peng, Ying-Ying; Zhu, Wen-Feng] Hunan Univ Tradit Chinese Med, Changsha, Hunan, Peoples R China.
通讯机构：
[Yan, Jun-Feng] H;Hunan Univ Tradit Chinese Med, Changsha, Hunan, Peoples R China.
关键词：
Rough Set;TCM;Syndrome Elements
摘要：
This article introduce the method of acquiring the syndrome related to the syndrome elements based on the rough set theory. Through the JOHNSON experimental study on spleen and YANG asthenia, we have a set of related data and then analyzed the result
作者机构：
[Huang, D.; Yue, C. H.; Li, S. X.] Hunan Acad Tradit Chinese Med, Hunan Prov Key Lab Drug Res, Changsha 410013, Peoples R China.;[Huang, D.; Yue, C. H.; Li, S. X.] Hunan Univ Tradit Chinese Med, Changsha 410007, Peoples R China.;[Long, M.; Li, S. X.; Zhang, Z. G.] Hunan Agr Univ, Changsha 410128, Peoples R China.;[Long, M.] SUNY Stony Brook, Stony Brook, NY 11794 USA.;[Zhang, Z. G.] Hunan Normal Univ, Changsha 410081, Peoples R China.
会议名称：
第九届全国中药和天然药物学术研讨会
会议时间：
2007-12-01
会议地点：
南昌
会议论文集名称：
第九届全国中药和天然药物学术研讨会论文集
关键词：
叶表面结构;骨碎补;柚皮苷;山奈酚;补肾成份
摘要：
OBJECTIVE：To study the kidney tonic components of Rhizoma Drynariae.METHODS：The herbal material was extracted with 50％ ethanol.Silica gel and sephadex LH-20 coluuln chromatography isolated the chemical components using the Opossurn Kidney cell for the living model.The structures were identified on the basis of chemical and spectroscopic data.RESULTS.Six monocases were isolated from the EtOH extract of in Rhizomes of Drynaria fortunei J.Sm..Four structures were identified as naringin(I)，neocriocitrin(Ⅱ)，kaempferol(Ⅲ)，and naringenin-7-O-β-D-glucoside(Ⅳ)，respectively，on the basis of its spectral and physicochemical evidence.The kaempferol call promote the proliferation of the Opossum Kidney cell tested by Promega’B CellTiter96 assay in vitr0.Others are in identifying.CONCLUSION：Compound In and IV are firstly isolated from this plant，and the later may hefurther developed into a new effective drug for treatingm rural failure.
摘要：
Objective: To observe the effect of tablet Yangxintongmai on atherosclerosis( AS) rats. Methods: 72 Wistar rats were divided into four groups, i.e. normal, model, control and therapy group. The AS model of rats was made by feeding with high grease food and AS plague was observed in the aorta after one month of feeding. Tablet Yangxintongmai was used in the group of therapy; tablet Gypenosides was used in the group of control. The level of serum lipid, blood sugar and insulin were tested after one month; the change of aorta histology was observed by HE staining; the ultrastructure of aorta tissue was observed by transmission electronic microscope; the apoptosis of aorta vascular smooth muscle (VSMC) and the expression of actin were evaluated by immunocytochemistry; the expression of VSMC genes such as c-myc, c-fos, PDGF-A, P53, bcl-2 mRNA were tested by RT-PCR. Results: In the therapy group, the level of TC, TG, plasmviscosity, erythrocyte hematocrit and platelet adhesion ratio(P < 0.05)decreased significantly; the level of HDL (P< 0.01), insulin sensitivity index increased; the plague regressed; the histology of aorto didn't change much; the expression of actin decreased; the gene expression of c-myc, PDGF-A, bcl-2(P < 0.05) were downregulated and P53(P < 0.05) was upregulated. Compared with the model group, the expression of c-fos mRNA was downregulated in the therapy group(P < 0.05). Conclusion: Tablet Yangxintongmai has significant effect on AS and the therapeutic molecular mechanism is inhibition of apoptosis and adjustment of the correlated gene expression.
