作者：
Song Yin;Xing Zheng;Xu Yao;Yuhong Wang;Duanfang Liao;...
期刊：
癌症治疗(英文),2013年4(1):113-123 ISSN：2151-1934
作者机构：
Division of Stem Cell Regulation and Application, State Key Laboratory of Chinese Medicine Powder and Medicine Innovation in Hunan (Incubation), Hunan University of Chinese Medicine, Changsha, China;Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China
摘要：
Curcumin has been reported to possess multifunctional bioactivities with low toxicity. However, the clinical application of curcumin has been significantly limited by its instability and poor metabolic property. Up to now, multiple approaches are being sought to overcome these limitations to obtaining “super curcumin”, and many analogues of curcumin have been designed and synthesized. In all of those analogues, a series of mono-carbonyl curcumin analogues deleting the β-diketone draw our attention. Since the seven-carbon β-diketone linker in curcumin may be responsible for its instability, the series of mono-carbonyl curcumin analogues deleting the β-diketone may be potential prodrug with improved pharmacokinetic and pharmacodynamic properties. This review just focuses on these more stable mono-carbonyl analogues of curcumin, and shows the new class of active structure by introducing the synthesis and anticancer activity of them.
作者：
Jinhong Liu;GuoZuo Xiong;DuanFang Liao;Qinhui Tuo
期刊：
African Journal of Pharmacy and Pharmacology,2013年7(19):1144-1147 ISSN：1996-0816
作者机构：
[Jinhong Liu; GuoZuo Xiong; DuanFang Liao; Qinhui Tuo] Learning Key Laboratory for Pharmacoproteomics,School of Life Science and Technology,University of South China;[Jinhong Liu; GuoZuo Xiong; DuanFang Liao; Qinhui Tuo] Department of General Surgery,The Second Affiliated Hospital in University of South China;[Jinhong Liu; GuoZuo Xiong; DuanFang Liao; Qinhui Tuo] Department of Traditional Chinese Diagnotics,School of Pharmacy,Hunan University of Chinese Medicine
会议名称：
第11届全国脂质与脂蛋白学术会议
会议时间：
2012-09-21
会议地点：
太原
会议论文集名称：
第11届全国脂质与脂蛋白学术会议论文集
摘要：
Death domain-associated protein (Daxx) was originally identiï¬ed as a protein that speciï¬cally binds to the death domain of the transmembrane death receptor Fas (also called CD95) in the cytoplasm and potentiates Fas-induced apoptosis. Over expression of Daxx enhances Fas-mediated apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx was found in the nuclears where it localizes to promyelocytic leukaemia (PML) oncogenic domains (PODs). As a highly conserved nuclear protein, Daxx plays an important role in proapoptosis, antiapoptosis and transcriptional regulation. This article reviews the latest advances in the study of the biological function of Daxx.
作者机构：
[Tang, Zhenwang] S China Univ, Affiliated Hosp 1, Dept Cardiol, Hengyang 421001, Peoples R China.;[Li, Xingsheng] Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr Cardiol, Chongqing 400010, Peoples R China.;[Liao, Duanfang] Hunan Univ Chinese Med, Dept Pharmacol, Changsha 410007, Hunan, Peoples R China.
通讯机构：
[Tang, Zhenwang] S;S China Univ, Affiliated Hosp 1, Dept Cardiol, Hengyang 421001, Peoples R China.
关键词：
The beta 2-adrenergic receptor gene;Polymorphism;Hypertension;Meta-analysis
摘要：
The beta 2-adrenergic receptor (beta 2-AR) gene has been implicated in the pathogenesis of hypertension. However, the results have been conflicting. In this study, we performed a meta-analysis to assess the associations of 46A/G and 79C/G polymorphisms in beta 2-AR gene with hypertension risk in Han Chinese population. Published literature from PubMed, ISI Web of Science, Embase databases, CNKI, CBM and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. Eleven studies (2,058 cases and 1,459 controls) for 46A/G polymorphism and eight studies (2,219 cases and 1,495 controls) for 79C/G polymorphism were identified. The results suggested that 46A/G polymorphism G allele might increase the risk of hypertension (GG vs. AA: OR = 1.47, 95 % CI 1.20-1.82). However, no significant association was observed for 79C/G polymorphism (GG vs. CC: OR = 1.05, 95 % CI 0.61-1.79). The results indicated that 46A/G polymorphism in the beta 2-AR gene was associated with hypertension susceptibility in Han Chinese population.
作者机构：
[Shuhua Cui; Qinhui Tuo; DuanFang Liao] Learning Key Laboratory for Pharmacoproteomics,School of Life Science and Technology,University of South China;[Shuhua Cui; Qinhui Tuo; DuanFang Liao] Department of Traditional Chinese Diagnotics,School of Pharmacy,Hunan University of Chinese Medicine
会议名称：
第11届全国脂质与脂蛋白学术会议
会议时间：
2012-09-21
会议地点：
太原
会议论文集名称：
第11届全国脂质与脂蛋白学术会议论文集
摘要：
<正>Objective:The aim of the present study was to determine the effect of Daxx on apoptosis of RAW264.7 cells induced by Chol.MpCD. Methods:The eukaryotic vector of Daxx was constructed to be stably tr
