Inflammasomes are multimeric complexes formed in the cytosol that play critical roles in eliciting innate immune responses against pathogens and other damage-associated signals. However, over inflammasome activation is also a major driver of autoimmune and metabolic disorders. The NLRP3 inflammasome is the most extensively investigated of the inflammasomes identified, which involvement in the pathogenesis of neurodegenerative diseases. In this review, we summarize the structure of the NLRP3 inflammasome, the function and the regul...
