期刊论文

Deng, CQ

英文

Biomedicine & Pharmacotherapy

0753-3322

2017

89

124-134

10.1016/j.biopha.2017.02.015

This study was supported by National Natural Science Foundation of China (Nos. 81573875; 81503385), Aid Project for Innovation Platform Open Fund of Hunan Province University (No. 14K068), Key Project of Administration of Traditional Chinese Medicine of Hunan Province (201508), General Project of Science and Technology Department of Hunan Province (No. 2014SK3001), Ministry of Education Key Laboratory Open Fund Established by the Province and the Ministry (ZYNK201405), Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province for “Related research on prevention and treatment of cardio-cerebrovascular diseases with integrated traditional Chinese and Western Medicine”, Hunan Province Natural Science Innovation Group for “Fundamental research of Chinese medicine on prevention and treatment of cardio-cerebrovascular diseases”.

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The aim of this study was to explore the effect by which the combination of Astragaloside IV (AST IV) and Ginsenoside Rg1 (Rg1) resisted autophagic injury in PC12 cells induced by oxygen glucose deprivation/reoxygenation (OGD/R). We studied the nature of the interaction between AST IV and Rg1 that inhibited autophagy through the Isobologram method, and investigated the synergistic mechanism via the PI3K I/Akt/mTOR and PI3K III/Becline-1/Bcl-2 signaling pathways. Our results showed that, based on the 50% inhibiting concentration (IC50), AST IV combined with Rg1 at a 1:1 ratio resulted in a syne...