期刊论文、会议论文

Huang, X.

中文

中国中药杂志

1001-5302

2010

35

16

2187-2191

第六届全国中西医结合基础理论研究学术研讨会暨第二届湖南省中西医结合学会肝病专业学术年会

2010-10-01

中国湖南长沙

10.4268/cjcmm20101634

湖南省教育厅重点项目(No:08A050)

本校为第一且通讯机构

目的:研究黄芪总苷(AST)和三七总皂苷(PNS)配伍对小鼠脑缺血再灌注后脑组织基质金属蛋白酶-9(matnx metalloproteinase-9,MMP-9)与组织基质金属蛋白酶抑制物-1(tissue inhibitor of metalloproteinase-1,TIMP-1)表达的影响,探讨其抗缺血性脑损伤的保护机制. 方法: C57BL/6N小鼠随机分成假手术组、模型组、AST和PNS配伍高、中、低剂量组、AST单用组、PNS单用组及依达拉奉组,连续给药4d后结扎双侧颈总动脉20 min,再灌注24 h,建立脑缺血再灌注模型,用HE染色检测海马区病理形态,用Western-blot法检测MMP-9与TIMP-1蛋白在脑组织的表达. 结果:各药物组神经元存活率显著高于模型组(P< 0.01),以配伍中剂...

OBJECTIVE: To investigate the effect of astragalosides (AST) and Panax notoginseng saponins (PNS) compatibility on the expression of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metal11oproteinase-1 (TIMP-1) after cerebral ischemia/reperfusion (I/R) injury in mice, to probe into its anti-ischemic brain injury protection mechanism. METHOD: C57BL/6N mice were randomly divided into sham-operation group, model group, AST and PNS compatibility of high, medium and low-dose group, AST group, PNS group and edaravone group. Cerebral ischemia-reperfusion injury were prepared by bilateral ...