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Combination of Total Astragalus Extract and Total Panax Notoginseng Saponins Strengthened the Protective Effects on Brain Damage through Improving Energy Metabolism and Inhibiting Apoptosis after Cerebral Ischemia-Reperfusion in Mice

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成果类型:
期刊论文
作者:
Huang Xiao-ping(黄小平);Tan Hua;Chen Bei-yang;Deng Chang-qing(邓常清
通讯作者:
Deng, CQ
作者机构:
[Deng Chang-qing; Huang Xiao-ping; Deng, CQ; Tan Hua] Hunan Univ Chinese Med, Key Lab Hunan Univ Cell Biol & Mol Tech, Key Lab Hunan Prov Prevent & Treatment Integrated, Changsha 410007, Hunan, Peoples R China.
[Chen Bei-yang] Hunan Univ Chinese Med, Dept Histol & Embryol, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Deng, CQ ] H
Hunan Univ Chinese Med, Key Lab Hunan Univ Cell Biol & Mol Tech, Key Lab Hunan Prov Prevent & Treatment Integrated, Changsha 410007, Hunan, Peoples R China.
语种:
英文
关键词:
total Astragalus extract;total Panax notoginseng saponins;combination;cerebral ischemia-reperfusion;energy metabolism;C-Jun N-terminal kinase signal transduction;mitochondrial apoptosis pathway;Chinese medicine
关键词(中文):
脑缺血再灌注;三七总皂苷;细胞凋亡;能量代谢;保护作用;脑损伤;小鼠;黄芪
期刊:
中国结合医学杂志
ISSN:
1672-0415
年:
2017
卷:
23
期:
6
页码:
445-452
基金类别:
Supported by National Natural Science Foundation of China (No. 81102557), Doctoral Program Foundation of Higher Education of China (No. 20104323110001), Key Project of Hunan Province Education Department (No. 08A050), Aid Project for Innovation Platform Open Fund of Hunan Province University (No. 11K050 and No. 14K068), Key Project of Administration of Traditional Chinese Medicine of Hunan Province (No. 201301), General Project of Science and Technology Department of Hunan Province (No. 2014SK3001), General Project of Education Bureau of Hunan Province (No. 11C0963)
机构署名:
本校为其他机构
院系归属:
医学院
中医学院
中西医结合学院
摘要:
Objective: To explore the effects and molecular mechanisms of the combination between total Astragalus extract (TAE) and total Panax notoginseng saponins (TPNS) against cerebral ischemia-reperfusion injury. Methods: C57BL/6 mice were randomly divided into sham-operated group, model group, TAE (110 mg/kg) group, TPNS (115 mg/kg) group, TAE-TPNS combination group and Edaravone (4 mg/kg) group, treated for 4 days, then, cerebral ischemia-reperfusion injury was established by bilateral common carotid artery (CCA) ligation for 20 min followed by rep...

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