期刊论文

Deng Chang-qing（邓常清）

英文

中国结合医学杂志

1672-0415

2017

23

6

445-452

10.1007/s11655-015-1965-0

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81102557]; Doctoral Program Foundation of Higher Education of China [20104323110001]; Key Project of Hunan Province Education Department [08A050]; Aid Project for Innovation Platform Open Fund of Hunan Province University [11K050, 14K068]; Key Project of Administration of Traditional Chinese Medicine of Hunan Province [201301]; General Project of Science and Technology Department of Hunan Province [2014SK3001]; General Project of Education Bureau of Hunan Province [11C0963]

本校为第一且通讯机构

Objective: To explore the effects and molecular mechanisms of the combination between total Astragalus extract (TAE) and total Panax notoginseng saponins (TPNS) against cerebral ischemiareperfusion injury. Methods: C57BL/6 mice were randomly divided into sham-operated group, model group, TAE (110 mg/kg) group, TPNS (115 mg/kg) group, TAE-TPNS combination group and Edaravone (4 mg/kg) group, treated for 4 days, then, cerebral ischemia-reperfusion injury was established by bilateral common carotid artery (CCA) ligation for 20 min followed by reperfusion for 1 and 24 h. Results: TPNS could increa...