作者机构：
[Wang, Haodong; Chen, Liang; Peng, Caiyun; Wang, Wei; Tian, Xing; Yuan, Hanwen] Hunan Univ Chinese Med, Innovat Mat Med Res Inst, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.;[Tian, Xing] Hunan Univ Chinese Med, Sch Pharm, Dept Food & Drug Engn, Changsha 410208, Peoples R China.;[Tian, Xing; Yuan, Hanwen] Engn Technol Res Ctr Hunan Prov Xiangnan Area Auth, Yongzhou 425600, Peoples R China.;[Peng, Caiyun] Wonkwang Univ, Confucius Inst, 460 Iksandae Ro, Iksan 54538, South Korea.
通讯机构：
[Wang, W ] H;Hunan Univ Chinese Med, Innovat Mat Med Res Inst, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.
摘要：
Chrysanthemum tea, a typical health tea with the same origin as medicine and food, is famous for its unique health benefits and flavor. The taste and sensory quality of chrysanthemum (Juhua) tea are mainly determined by secondary metabolites. Therefore, the present research adopted untargeted metabolomics combined with an electronic tongue system to analyze the correlation between the metabolite profiles and taste characteristics of different varieties of chrysanthemum tea. The results of sensory evaluation showed that there were significant differences in the sensory qualities of five different varieties of chrysanthemum tea, especially bitterness and astringency. The results of principal component analysis (PCA) indicated that there were significant metabolic differences among the five chrysanthemum teas. A total of 1775 metabolites were identified by using untargeted metabolomics based on UPLC-Q-TOF/MS analysis. According to the variable importance in projection (VIP) values of the orthogonal projections to latent structures discriminant analysis (OPLS-DA), 143 VIP metabolites were found to be responsible for metabolic changes between Huangju and Jinsi Huangju tea; among them, 13 metabolites were identified as the key metabolites of the differences in sensory quality between them. Kaempferol, luteolin, genistein, and some quinic acid derivatives were correlated with the "astringency" attributes. In contrast, l-(-)-3 phenyllactic acid and L-malic acid were found to be responsible for the "bitterness" and "umami" attributes in chrysanthemum tea. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the flavonoid and flavonol biosynthesis pathways had important effects on the sensory quality of chrysanthemum tea. These findings provide the theoretical basis for understanding the characteristic metabolites that contribute to the distinctive sensory qualities of chrysanthemum tea.
期刊：
Frontiers in Neurology,2024年15:1334657 ISSN：1664-2295
通讯作者：
Chi, H;Huang, SK
作者机构：
[Chi, Hao; Tang, Jingyi; Gu, Yuheng; Chi, H; Zhou, Xuancheng; Zhang, Shengke; Jiang, Lai] Southwest Med Univ, Clin Med Coll, Luzhou, Peoples R China.;[Zhang, Jieying] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China.;[Zhang, Jieying] Natl Clin Res Ctr, Chinese Med Acupuncture & Moxibust, Tianjin, Peoples R China.;[Pu, Tong] Hunan Univ Chinese Med, Coll Acupuncture & Tuina & Rehabil, Changsha, Peoples R China.;[Quan, Xiaomin] Beijing Chinese Med Second Affiliated Dong Fang Ho, Dept Oncol, Beijing, Peoples R China.
通讯机构：
[Chi, H ; Huang, SK ] S;Southwest Med Univ, Clin Med Coll, Luzhou, Peoples R China.;Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou, Peoples R China.
关键词：
Acupuncture point stimulation;Stomach cancer pain;therapeutic efficacy;Traditional Chinese Medicine;Meta-analysis
摘要：
Purpose: In recent years, traditional Chinese medicine has received widespread attention in the field of cancer pain treatment. This meta-analysis is the first to evaluate the effectiveness and safety of acupuncture point stimulation in the treatment of stomach cancer pain. Methods: For this systematic review and meta-analysis, we searched PubMed, Web of Science, Cochrane Library, Embase, WANFANG, China National Knowledge Infrastructure (CNKI), and Chinese Journal of Science and Technology (VIP) databases as well as forward and backward citations to studies published between database creation to July 27, 2023. All randomized controlled trials (RCTs) on acupuncture point stimulation for the treatment of patients with stomach cancer pain were included without language restrictions. We assessed all outcome indicators of the included trials. The evidence from the randomized controlled trials was synthesized as the standardized mean difference (SMD) of symptom change. The quality of the evidence was assessed using the Cochrane Risk of Bias tool. This study is registered on PROSPERO under the number CRD42023457341. Results: Eleven RCTs were included. The study included 768 patients, split into 2 groups: acupuncture point stimulation treatment group (n = 406), medication control group (n = 372). The results showed that treatment was more effective in the acupuncture point stimulation treatment group than in the medication control group (efficacy rate, RR = 1.63, 95% CI 1.37 to 1.94, p < 0.00001), decreasing in NRS score was greater in acupuncture point stimulation treatment group than in the medication control group (SMD = −1.30, 95% CI −1.96 to −0.63, p < 0.001). Systematic Review Registration: https://clinicaltrials.gov/, identifier CRD42023457341.
期刊：
Frontiers in Microbiology,2024年15:1378311 ISSN：1664-302X
作者机构：
[Yu, Yunfeng; Hu, Gang; Yu, Rong] The First Hospital of Hunan University of Chinese Medicine, Changsha, China;[Tong, Keke] The Hospital of Hunan University of Traditional Chinese Medicine, Changde, China;[Yang, Xinyu; Bai, Siyang] College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China;[Wu, Jingyi] The Third School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China
摘要：
OBJECTIVE: The impact of hepatitis B virus (HBV) on the risk of type 2 diabetes (T2D) remains a controversial topic. This study aims to analyze the causal relationship between HBV and T2D using Mendelian randomization (MR). METHODS: Single nucleotide polymorphisms on chronic hepatitis B (CHB), liver fibrosis, liver cirrhosis, and T2D were obtained from BioBank Japan Project, European Bioinformatics Institute, and FinnGen. Mendelian randomization was utilized to evaluate exposure-outcome causality. Inverse variance weighted was used as the primary method for MR analysis. To assess horizontal pleiotropy and heterogeneity, we conducted MR-Egger intercept analysis and Cochran's Q test, and the robustness of the MR analysis results was evaluated through leave-one-out sensitivity analysis. RESULTS: MR analysis revealed that CHB was associated with a decreased genetic susceptibility to T2D (OR, 0.975; 95% CI, 0.962-0.989; p < 0.001) while liver cirrhosis (OR, 1.021; 95% CI, 1.007-1.036; p = 0.004) as well as liver cirrhosis and liver fibrosis (OR, 1.015; 95% CI, 1.002-1.028; p = 0.020) were associated with an increased genetic susceptibility to T2D. MR-Egger intercept showed no horizontal pleiotropy (p > 0.05). Cochran's Q showed no heterogeneity (p > 0.05). Leave-one-out sensitivity analysis showed that the results were robust. CONCLUSION: CHB has the potential to act as a protective factor for T2D, but its effectiveness is constrained by viral load and disease stage. This protective effect diminishes or disappears as viral load decreases, and it transforms into a risk factor with the progression to liver fibrosis and cirrhosis.
作者机构：
[Li, Tiandan; Hu, Xiaochao; Fan, Lingyang] Hunan Provincial Key Laboratory of Dong Medicine, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Science, Hunan University of Medicine,Huaihua,Hunan 418000,China;[Yang, Yong] chool of Pharmacy, Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410208,China. Electronic address: yangyong@hnucm.edu.cn;[He, Kai] Hunan Provincial Key Laboratory of Dong Medicine, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Science, Hunan University of Medicine,Huaihua,Hunan 418000,China. Electronic address: hekai69@email.swu.edu.cn
通讯机构：
[Yang, Yong] c;[He, Kai] H;chool of Pharmacy, Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410208,China. Electronic address:;Hunan Provincial Key Laboratory of Dong Medicine, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Science, Hunan University of Medicine,Huaihua,Hunan 418000,China. Electronic address:
摘要：
Myricanol (MY) is one of the main active components from bark of Myrica Rubra. It is demonstrated that MY rescues dexamethasone (DEX)-induced muscle dysfunction via activating silent information regulator 1 (SIRT1) and increasing adenosine 5'-monophosphate-activated protein kinase (AMPK) phosphorylation. Since SIRT1 and AMPK are widely involved in the metabolism of nutrients, we speculated that MY may exert beneficial effects on DEX-induced metabolic disorders. This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Metabolomics showed that MY treatment reversed the serum content of carnitine ph-C1, palmitoleic acid, PS (16:0_17:0), PC (14:0_20:5), PE (P-18:1_16:1), Cer (t18:2/38:1(2OH)), four amino acids and their metabolites, and 16 glycerolipids in DEX mice. Kyoto encyclopedia of genes and genomes (KEGG) and metabolic set enrichment analysis (MSEA) analysis revealed that MY mainly affected metabolic pathways, glycerolipid metabolism, lipolysis, fat digestion and absorption, lipid and atherosclerosis, and cholesterol metabolism pathways through regulation of metabolites involved in glutathione, butanoate, vitamin B6, glycine, serine and threonine, arachidonic acid, and riboflavin metabolism. Collectively, MY can be used as an attractive therapeutic agent for DEX-induced metabolic abnormalities.
作者机构：
[Zeng, Li; Rao, Zehua; Luo, Zhiqiang; Lu, Chengyin; Xiong, Hui] Department of the Second Clinic College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China;[Wang, Xiaohui; Lu, Chengyin] Department of Orthopedics, Luoyang Orthopedic-Traumatological Hospital of Henan Province (Henan Provincial Orthopedic Hospital), Luoyang, China;[Wang, Mingxuan] Department of the second Clinical Medical College, Shanxi Medical University, Taiyuan, China;[Zhou, Biao] Department of Orthopedics, The First People's Hospital of Xiangtan City, Xiangtan, China;[Zhou, Biao] Department of Orthopedics, Wangjing Hospital of Chinese Academy of Chinese Medical Science, Beijing, China
摘要：
BACKGROUND: Wrist arthroscopy technology is a surgical technology invented in recent years and widely used in clinical treatment of various wrist diseases. This study uses the methods of bibliometrics and visual analysis to understand the global research status, research hotspots, and future development trends of wrist arthroscopy. METHODS: The relevant literature of global publications on wrist arthroscopy from 2013 to 2023 was extracted from the Web of Science Core Collection database, and the annual output, cooperation, hot spots, research status, and development trend of this field were analyzed by using the bibliometric software (VOSviewers, CiteSpace, and the R package "Bibliometrix"). RESULTS: A total of 635 articles were included, from 2013 to 2023, the number of publications related to wrist arthroscopy showed an overall upward trend, the USA, France, and China are the top 3 countries in terms of the number of publications, whereas Mayo Clinic is the institution with the highest number of publications, Ho PC holds a core position in this field, keyword analysis indicates that the research hotspots are the applications of wrist arthroscopy in triangular fibrocartilage complex injuries, scaphoid nonunion, and avascular necrosis of the lunate. CONCLUSION SUBSECTIONS: Wrist arthroscopy has shown tremendous potential in treating various wrist diseases. However, there are still some challenges in its research domain. With continuous deep research, strengthened international collaboration, and ongoing technological advancements, wrist arthroscopy has the potential to become the standard treatment in hand surgery, offering more efficient and safer treatment options for patients worldwide.
期刊：
FRONTIERS IN PSYCHIATRY,2024年15:1304916 ISSN：1664-0640
通讯作者：
Li, JS;Chen, M
作者机构：
[Lyu, Kaifeng; Chen, Min] Macau Univ Sci & Technol, Fac Chinese Med, Macau, Peoples R China.;[Li, Wu; Feng, Xiang; Li, Jiangshan; Zhang, Yuxing] Hunan Univ Tradit Chinese Med, Coll Acupuncture Moxibust Massage & Rehabil, Changsha, Peoples R China.;[Chen, Min] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.;[Zhang, Wei] Heilongjiang Univ Tradit Chinese Med, Affiliated Hosp 1, Pediat 1, Harbin, Peoples R China.;[Hu, Meichao] Chifeng Obstet & Gynecol Hosp, Chifeng Obstet & Gynecol Hospitalal, Chifeng, Peoples R China.
通讯机构：
[Li, JS ] H;[Chen, M ] M;Hunan Univ Tradit Chinese Med, Coll Acupuncture Moxibust Massage & Rehabil, Changsha, Peoples R China.;Macau Univ Sci & Technol, Fac Chinese Med, Macau, Peoples R China.;Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
摘要：
BACKGROUND: This study employs bibliometric methods to comprehensively understand the fundamental structure of research about Autism Spectrum Disorder (ASD) Signaling Pathways by examining key indicators such as nations, institutions, journals, authors, and keywords. METHODOLOGY: We utilized the WoScc database to retrieve literature relevant to ASD Signaling Pathways published between 2013 and 2023. Through visual analysis and tools like CiteSpace and VosViewer, we explored nations, institutions, journals, authors, and keywords, thereby constructing relevant networks. RESULTS: 26 The study encompasses 1,396 articles, revealing a consistent increase in publications. The United States, China, and Germany are leading nations in this literature. Regarding research institutions, the University of California system and Eric Klann have garnered significant attention due to their substantial contributions to the field of ASD Signaling Pathways. Most relevant research is published in the journal "Molecular Autism." Research interests are concentrated across various themes, including "elevating neuronal β-catenin levels," "Tunisian children," "Fmr1 knockout (KO) mice," "de novo mutations," "autistic children," "local translation," "propionic acid-induced mouse models," "neurosystems," "glucose metabolism," and "neuronal migration." Future research may emphasize exploring aspects such as gut microbiota, genes, stress, maternal immune activation, memory, and neurodevelopmental disorders of ASD. CONCLUSION: This study, through bibliometric analysis of key indicators such as nations, institutions, journals, authors, and keywords, provides a comprehensive overview of the current state of research on ASD Signaling Pathways. These investigations predominantly focus on molecular mechanisms, animal model studies, population-based research, and the structure and function of neurosystems. Future research directions are also clearly proposed. First, in-depth research on the genes and neurodevelopmental disorders associated with ASD will continue to reveal the genetic basis and provide support for precise treatments. At the same time, attention to the gut microbiota will help explore its association with ASD, which may provide clues for new treatments. In addition, the relationship between stress and ASD will become the focus of research to understand better the emotional and behavioral characteristics of ASD patients in stressful situations. Maternal immune activation will also be further studied to explore how environmental factors influence the risk and development of ASD. Finally, a deeper understanding of the cognitive functions of patients with ASD, especially memory and learning, will help develop individualized treatment strategies to improve patients' quality of life. These directions will work together and are expected to provide a more comprehensive understanding of Signaling Pathways research in ASD and provide new ideas and opportunities for future intervention and treatment.
