作者机构：
[彭佳欣] College of Intergrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China;[胡梅; 陶阳阳; 彭江敏] College of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China;[刘灵芝; 袁菊] College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China;Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China;Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Lin, T.] H;Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, China
作者机构：
[卢芳国; 熊涛] Department of Microbiology, School of Medicine, Hunan University of Chinese Medicine, Hunan, Changsha, 410219, China;[郑涛; 李佳珊; 刘佳豪; 郭锦璐] School of Stomatology, Hunan University of Chinese Medicine, China
通讯机构：
[Xiong, T.; Lu, F.-G.] D;Department of Microbiology, Hunan, China
摘要：
Objective:To study the effect of effective components of Yixintai(益心泰)on left ventricular hypertrophy and cardiomyocyte apoptosis in rabbits with chronic heart failure(CHF)and its mechanism.Methods:Twenty New Zealand rabbits were randomLy selected from 120 rabbits as th...MORE Objective:To study the effect of effective components of Yixintai(益心泰)on left ventricular hypertrophy and cardiomyocyte apoptosis in rabbits with chronic heart failure(CHF)and its mechanism.Methods:Twenty New Zealand rabbits were randomLy selected from 120 rabbits as the sham operation group,and the remaining 100 rabbits were used to establish the rabbit model of CHF by coarctation of the abdominal aorta and intragastric administration of propylthiouracil.The rabbits successfμLly modeled were randomLy divided into a model control group,2.1 g/kg,4.2 g/kg,and 8.4 g/kg of Yixintai effective components groups,and a 2.75 mg/kg losartan potassium group.An equal volume of distilled water was orally administrated to rabbits in the model control group and sham operation control group,once per day,for 4 weeks.After treatment,the myocardial pathological structure,the level of N-terminal B-type natriuretic peptide(NT-pro BNP)in the serum,cardiacμLtrasound parameters,hemodynamic parameters,left ventricular mass index,cardiomyocyte apoptosis,and the protein and mRNA expression levels of c-Jun N-terminal kinase(Cjun),serum response element(Cfos)in myocardial tissues were observed.Results:As compared with the sham operation group,the serum level of NT-pro BNP in the model control group was significantly increased(P<0.01),the left ventricular ejection fraction(LVEF)and the left ventricular systolic pressure(LVSP)were decreased(P<0.01),the left ventricular posterior wall thickness(LVPWT)and the left ventricular end-diastolic pressure(LVEDP)were increased(P<0.01),the left ventricular mass index and the cardiomyocyte apoptosis were increased(P<0.01),and the protein and mRNA expression of Cjun and Cfos in myocardial tissues were up-regulated(P<0.01).As compared with the model control group,the serum level of NT-pro BNP in each treatment group was significantly decreased(P<0.01),the LVEF and the LVSP were increased(P<0.01),the LVPWT and the LVEDP were decreased(P<0.01),the cardiomyocyte apoptosis were decreased(P<0.01),and the protein and mRNA expression of Cjun and Cfos in myocardial tissues were down-regulated(P<0.05,P<0.01).The left ventricular mass index in the 2.75 mg/kg losartan potassium group and 4.2 g/kg and 8.4 g/kg of Yixintai effective components groups were significantly decreased(P<0.01).Conclusion:The effective components of Yixintai can inhibit the protein and mRNA expressions of Cjun and Cfos in myocardial tissues of rabbits with CHF,reduce left ventricular hypertrophy and cardiomyocyte apoptosis,and improve heart failure.FEWER
作者机构：
[胡伊蕾; 赵彦禛; 周曼丽; 张宜帆; 俞赟丰] School of Traditional Chinese Medicine（TCM), Hunan University of Chinese Medicine, Changsha, 410208, China;Hunan Provincial Key Laboratory of Diagnostics of TCM, Hunan University of Chinese Medicine, Changsha, 410208, China;[简维雄] School of Traditional Chinese Medicine（TCM), Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Provincial Key Laboratory of Diagnostics of TCM, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Jian, W.] S;School of Traditional Chinese Medicine（TCM), China
