Effect of Chaihu-Shugan-San on the mRNA expression of the 5-HT1A receptor and cellular proliferation in the hippocampus of epileptic rats with depression
作者：
Yang, Ping;Li, Liang
（ ;Liu, Xue-Jun;Cai, Xiong
（ ;Sun, Mei-Zhen;...
期刊：
Experimental and Therapeutic Medicine ,2016年11(1):124-130 ISSN：1792-0981
通讯作者：
Huang, Hui-Yong
（ 作者机构：
[Yang, Ping; Liu, Xue-Jun] Hunan Brain Hosp, Dept Psychiat, Changsha 410007, Hunan, Peoples R China.;[Li, Liang; Cai, Xiong; He, Jun-Feng; Zeng, Guang; Huang, Hui-Yong] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha 410208, Hunan, Peoples R China.;[Li, Liang] Hunan Univ Chinese Med, Dept Anat, Changsha 410208, Hunan, Peoples R China.;[Sun, Mei-Zhen] First Hosp Shanxi Med Univ, Dept Neurol, Taiyuan 030001, Shanxi, Peoples R China.;[Huang, Hui-Yong] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, 300 Xueshi Rd,Hanpu Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.
通讯机构：
[Huang, Hui-Yong] H;Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, 300 Xueshi Rd,Hanpu Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.
会议名称：
Paediatric Virology Workshop
会议时间：
OCT 10-10, 2015
会议地点：
Athens, GREECE
会议主办单位：
[Yang, Ping;Liu, Xue-Jun] Hunan Brain Hosp, Dept Psychiat, Changsha 410007, Hunan, Peoples R China.^[Li, Liang;Cai, Xiong;He, Jun-Feng;Zeng, Guang;Huang, Hui-Yong] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha 410208, Hunan, Peoples R China.^[Li, Liang] Hunan Univ Chinese Med, Dept Anat, Changsha 410208, Hunan, Peoples R China.^[Sun, Mei-Zhen] First Hosp Shanxi Med Univ, Dept Neurol, Taiyuan 030001, Shanxi, Peoples R China.
关键词：
5-hydroxytryptamine 1A receptor;Chaihu-Shugan-San;cell proliferation;chronic mild stress;epilepsy with depression
摘要：
Chaihu-Shugan-San (CHSGS) is a herbal preparation that has been shown to effectively relieve neurologic impairment and reduce depression. However, the efficacy of CHSGS in the treatment of patients with epilepsy with depression is unknown. Therefore, in the present study, adult rats were exposed to chronic mild stress following the establishment of chronic pilocarpine‑induced epilepsy. Subsequently, a sucrose consumption test and open‑field test (OFT) were performed to assess depression‑like behavior. Rats were randomly divided into four groups: Control, model, fluoxetine (1.8 g/kg) and CHSGS (2.7 g/kg) groups. The control and model groups received normal saline. The mRNA expression levels of the 5‑hydroxytryptamine 1A (5‑HT1A) receptor and the number of 5‑bromo‑2’‑deoxyuridine (BrdU)‑labeled cells in the hippocampal dentate gyrus were detected using reverse transcription‑quantitative polymerase chain reaction and immunohistochemical analysis, respectively. Treatment administration was conducted by once daily intragastric perfusion for 28 days. The mRNA expression levels of the 5‑HT1A receptor, the number of BrdU‑labeled cells in the hippocampal dentate gyrus, the consumption of sucrose, and frequency of vertical and horizontal movement scores in the OFT were enhanced in the fluoxetine and CHSGS groups compared with the model group (P<0.05). However, no statistically significant difference was detected between the fluoxetine and CHSGS groups. These data suggest that CHSGS is able to increase the expression of 5‑HT1A receptor mRNA and cellular proliferation in the hippocampal dentate gyrus in epileptic rats with depression, and thus effectively improve certain symptoms of depression. © 2016, Spandidos Publications. All rights reserved.
语种：
英文
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GW26-e1477 Effect of the JNK signal pathway on the differentiation of bone marrow mesenchymal stem cells into cardiomyocytes induced by the active principle regions of Yangxin Tongmai Decoction
作者：
Zheng, Jinghui;Liang, Jian;Luo, Shuang;Jian, Weixiong;Ning, Guilan;...
期刊：
Journal of the American College of Cardiology ,2015年66(16, Supplement):C105-C105 ISSN：0735-1097
作者机构：
[Ma, Xiaocong; Xu, Mingdong; Chen, Xia; Luo, Shuang; Zheng, Jinghui; Liang, Jian; Ning, Guilan; Wang, Tiehua; Wu, Fasheng; Jiang, Zuling] Guangxi Univ Chinese Med, Ruikang Hosp, Dept Cardiovasc Med, Nanning, Peoples R China.;[Jian, Weixiong] Hunan Univ Chinese Med, Natl Key Discipline Tradit Chinese Med Diagnost, Changsha, Hunan, Peoples R China.
会议名称：
26th Great Wall International Congress of Cardiology (GW-ICC) / Asia Pacific Heart Congress (APHC) / International Congress of Cardiovascular Prevention and Rehabilitation (ICCPR)
会议时间：
OCT 29-NOV 01, 2015
会议地点：
Beijing, PEOPLES R CHINA
语种：
英文
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DAXX AS A NOVEL TARGET IN THE PREVENTION OF ATHEROSCLEROSIS
作者：
Liao, D.;Tuo, Q.;Xu, G.;Su, B.;He, Q.;...
作者机构：
[Liao, D.] Hunan Univ Chinese Med, Dept Tradit Chinese Diagnot, Changsha, Hunan, Peoples R China.;[Su, B.; Xu, G.; Zhu, B.; Tuo, Q.; He, Q.] Univ S China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.
会议名称：
79th Congress of the European-Atherosclerosis-Society (EAS)
会议时间：
JUN 26-29, 2011
会议地点：
Gothenburg, SWEDEN
语种：
英文
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