关键词：
Melancholic major depressive disorder;Default mode network;Network homogeneity;Resting-state imaging
摘要：
Background: Melancholic depression is a relatively homogenous subtype of major depressive disorders (MDD). The condition has several endogenous symptoms and represents strong biological components. However, its specific neurobiological mechanisms remain unknown. Previous neuroimaging findings indicated that default mode network (DMN) is closely related to MDD. The present study examined the network homogeneity (NH) of the DMN in patients with melancholic MDD. Methods: A total of 33 first-episode, treatment-naive melancholic MDD patients and 32 healthy controls underwent a resting-state functional magnetic resonance imaging scan. The data were analyzed using the NH method. Results: Compared with healthy controls, patients with melancholic MDD showed low NH values in the right middle temporal gyrus and temporal pole (MTG/FP). The abnormal NH of this region and clinical characteristics were not correlated. Conclusion: Abnormal NH pattern of DMN exists in patients with melancholic MDD. This feature may be part of the pathophysiological basis of this disorder. (C) 2016 Elsevier B.V. All rights reserved.
作者机构：
[Gong, Jing-bo; Chan, Raymond C. K.; Wang, Ya; Lui, Simon S. Y.] Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China.;[Gong, Jing-bo] Hunan Univ Chinese Med, Dept Appl Psychol, Changsha, Hunan, Peoples R China.;[Cheung, Eric F. C.; Lui, Simon S. Y.] Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China.;[Chan, Raymond C. K.] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.;[Chan, Raymond C. K.] Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
通讯机构：
[Chan, Raymond C. K.] C;Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
摘要：
Childhood trauma has been shown to be a robust risk factor for mental disorders, and may exacerbate schizotypal traits or contribute to autistic trait severity. However, little is known whether childhood trauma confounds the overlap between schizotypal traits and autistic traits. This study examined whether childhood trauma acts as a confounding variable in the overlap between autistic and schizotypal traits in a large non-clinical adult sample. A total of 2469 participants completed the Autism Spectrum Quotient (AQ), the Schizotypal Personality Questionnaire (SPQ), and the Childhood Trauma Questionnaire-Short Form. Correlation analysis showed that the majority of associations between AQ variables and SPQ variables were significant (p < 0.05). In the multiple regression models predicting scores on the AQ total, scores on the three SPQ subscales were significant predictors(Ps < 0.05). Scores on the Positive schizotypy and Negative schizotypy subscales were significant predictors in the multiple regression model predicting scores on the AQ Social Skill, AQ Attention Switching, AQ Attention to Detail, AQ Communication, and AQ Imagination subscales. The association between autistic and schizotypal traits could not be explained by shared variance in terms of exposure to childhood trauma. The findings point to important overlaps in the conceptualization of ASD and SSD, independent of childhood trauma.
期刊：
IRANIAN JOURNAL OF PUBLIC HEALTH,2017年46(9):1223-1230 ISSN：2251-6085
通讯作者：
He, Guoping
作者机构：
[Zhang, Yinhua] Cent S Univ, Sch Nursing, Dept Community Nursing, Changsha, Hunan, Peoples R China.;[Liu, Honghua; He, Guoping; Zhang, Yinhua; Chen, Yang; Pan, Xiaoyan; Yuan, Qun; Xu, Yi; Yi, Xia] Hunan Univ Tradit Chinese Med, Sch Nursing, Dept Fundamentals Nursing, Changsha, Hunan, Peoples R China.;[Liu, Jingwei] Med Insurance Bur Hunan Prov, Changsha, Hunan, Peoples R China.
通讯机构：
[He, Guoping] H;Hunan Univ Tradit Chinese Med, Sch Nursing, Dept Fundamentals Nursing, Changsha, Hunan, Peoples R China.
关键词：
Antimicrobial;China;Inpatient;Prescription
摘要：
BACKGROUND: China had implemented policies to limit antimicrobials prescription since 2004; we conducted this study to reflect the effect of these national policies by analyzing antimicrobial prescription trends of medical insurance in patients from 2003 to 2014 in Changsha city, China. METHODS: The participants were inpatients of the medical insurance of urban workers (UEBMI). Data were extracted from medical insurance information system of Changsha Medical Insurance Institution, which directly connects with hospitals information systems. RESULTS: Trend analysis showed great changes in antimicrobial prescription and inpatients' cost on antimicrobials over the study period. Antimicrobial prescription rates gradually declined over the study period from 79.0% in 2003 to 43.5% in 2014 (adjusted OR0.205; 95%CI 0.198 to 0.213). There was a quicker decline from 2011 to 2014 (with implementing national antimicrobial stewardship action plan) than the period from 2003 to 2010 (with implementing antimicrobials use education and self-management strategies). The proportion of inpatients used one antimicrobial increased significantly from 25.6% in 2003 to 46.7% in 2014, while the proportion of inpatients used three or more antimicrobials gradually decreased. Bacterial culture rate increased from 20.4% in 2003 to 36.6% in 2014 (adjusted OR 2.248; 95% CI 2.149 to 2.352). The average costs on antimicrobials decreased significantly, from 277.43 US Dollar in 2003 to 91.05 US Dollar in 2014. CONCLUSION: National efforts to promote rational use of antimicrobials in clinical practice have had a positive effect over the past decade in China.
期刊：
Journal of Ethnopharmacology,2017年201:73-81 ISSN：0378-8741
通讯作者：
Liu, Xinmin
作者机构：
[Pan, Ruile; Lu, Cong; Sun, Xiuping; Shi, Zhe; Liu, Xinmin] Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing, Peoples R China.;[Pan, Ruile; Lu, Cong; Sun, Xiuping; Shi, Zhe; Liu, Xinmin] Peking Union Med Coll, Beijing, Peoples R China.;[Chen, Shanguang; Li, Yinghui; Qu, Lina] China Astronaut Res & Training Ctr, Beijing, Peoples R China.;[Sun, Lihua; Dang, Haixia] Chinese Acad Chinese Med Sci, Beijing, Peoples R China.;[Chen, Lingling; Bu, Lanlan; Liu, Xinmin] Hunan Univ Tradit Chinese Med, Changsha, Hunan, Peoples R China.
通讯机构：
[Liu, Xinmin] C;[Liu, Xinmin] P;[Liu, Xinmin] H;Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing, Peoples R China.;Peking Union Med Coll, Beijing, Peoples R China.
期刊：
South African Journal of Psychiatry,2017年23(1):1025 ISSN：1608-9685
通讯作者：
Zhang, Bin
作者机构：
[Wang, Yefei] Second Xiangya Hosp, Dept Psychiat, Changshashih, Hunan, Peoples R China.;[Wang, Yefei] Second Xiangya Hosp, Mental Hlth Inst, Changshashih, Hunan, Peoples R China.;[Wang, Yefei; Zhang, Bin] Hunan Univ Chinese Med, Dept Appl Psychol, Changsha, Hunan, Peoples R China.
通讯机构：
[Zhang, Bin] H;Hunan Univ Chinese Med, Dept Appl Psychol, Changsha, Hunan, Peoples R China.
摘要：
The dual model of perfectionism was adopted to explore the influence of adaptive and maladaptive perfectionism on depression in college students. The results support the dual process model of perfectionism in Chinese undergraduates. A sample of 206 Chinese undergraduates completed measures of perfectionism, General Self-efficacy Measure, Beck Depression Inventory, State Anxiety Inventory, Positive and Negative Affect Scale (Time 1) and Beck Depression Inventory 4 months later (Time 2). Exploratory and confirmatory factor analysis revealed that the three-factor model of perfectionism with dimensions of maladaptive perfectionism, adaptive perfectionism and order factor fit the date well. Partial correlations analyses revealed that maladaptive perfectionism was related to psychopathology, whereas adaptive perfectionism was more closely correlated with positive features of mental health. In cross-sectional analyses, the discrepancy which measures the perceived difference between the standards one has set for one's own behaviour and actual performance and the socially prescribed perfectionism subscales of maladaptive perfectionism could significantly predict baseline depressive symptoms. However, after controlling for the initial scores of depression, none of the perfectionism subscales significantly predicted the change in depression across a 4-month lag. Distinguishing adaptive and maladaptive aspects of perfectionism may be beneficial to understanding the influence of perfectionism on depression.
期刊：
Journal of Affective Disorders,2017年224:56-60 ISSN：0165-0327
通讯作者：
Wang, Yuhong
作者机构：
[Meng, Pan; Wang, Yuhong] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.;[Han, Yuanshan; Yang, Hui] Hunan Univ Chinese Med, Hosp 1, Cent Lab, Changsha 410007, Hunan, Peoples R China.
通讯机构：
[Wang, Yuhong] H;Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.
关键词：
Diabetes;Depression;25-hydroxyvitamin D
摘要：
Background: Because of the absence of data on the direct association between vitamin D and depression in patients with diabetes, we examined the association between vitamin D state (assessed by 25-hydroxyvitamin D [ 25(OH) D]) and the prevalence of depression in adult patients with type 2 diabetes mellitus(T2DM). Method: Cross-sectional data were obtained from 2786 patients with T2DM recruited from a Chinese diabetes registry. Patients' records were reviewed to obtain data pertaining to age, sex, Body Mass Index (BMI), marital status, level of education, smoking status, duration of diabetes mellitus, use of insulin, and presence of additional illnesses. A multiple logistic regression analysis adjusted for potential confounders was used to assess independent associations between serum levels of 25 (OH) D and depression (defined by the Patient Health Questionnaire-9). Results: Using the PHQ-9 cutoff value of >= 10, 5.71% (159/2786; 95% CI: 4.85-6.57%) were considered to have depression. The serum 25(OH) D levels were significantly lower in diabetic patients with depression than those patients without depression [10.2(IQR, 7.6-15.2) ng/ml vs. 14.6(IQR, 10.7-19.8)ng/ml, respectively; P < 0.0001]. Multivariate logistic regression analysis considering traditional risk factors and other biomarkers showed an inverse relationship between serum 25 (OH) D levels and depression when serum 25 (OH) D were used as a continuous variable (OR, 0.84; 95% CI, 0.77-0.90; P < 0.001). Compared with the first quartile of serum 25 (OH) D levels, the second quartile OR for depression was 0.83 (95% CI, 0.75-0.92, P=0.012). For the third and fourth quartiles, it was 0.40 (95% CI, 0.33-0.52, P < 0.001) and 0.15 (95% CI, 0.08-0.22; P < 0.001), respectively. Conclusions: We observed a significant negative association between serum levels of 25 (OH) D and depression in Chinese patients with T2DM.
作者机构：
[Xu, G. C.; Jiao, L. Y.] Gannan Med Univ, Ganzhou 341000, Peoples R China.;[Li, Y. C.; Wang, J. X.] Hunan Univ Tradit Chinese Med, Postgrad Sch, Changsha 410208, Hunan, Peoples R China.;[Li, Y. C.] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Neurol, Changsha 410007, Hunan, Peoples R China.
会议名称：
5th Chinese Congress on Gerontology and Health Industry (CCGI)
作者机构：
[Huang, Z. Q.] Gannan Med Univ, Coll Pharm, Ganzhou 341000, Peoples R China.;[Li, Y. C.; Wang, J. X.] Hunan Univ Tradit Chinese Med, Postgrad Sch, Changsha 410208, Hunan, Peoples R China.;[Li, Y. C.] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Neurol, Changsha 410007, Hunan, Peoples R China.
会议名称：
5th Chinese Congress on Gerontology and Health Industry (CCGI)
期刊：
Acupuncture in Medicine,2015年33(2):121-128 ISSN：0964-5284
通讯作者：
Liang, Fanrong
作者机构：
[Li, Ying; Liang, Fanrong; Zheng, Qianhua; Zheng, Hui; Li, Juan] Chengdu Univ Tradit Chinese Med TCM, Chengdu, Sichuan, Peoples R China.;[Huang, Wenjing] Charite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.;[Chang, Xiaorong] Hunan Univ Tradit Chinese Med TCM, Changsha, Hunan, Peoples R China.;[Sun, Guojie] Hubei Univ Tradit Chinese Med TCM, Wuhan, Hubei, Peoples R China.;[Liang, Fanrong] Chengdu Univ Tradit Chinese Med TCM, 37 Shi Er Qiao Rd, Chengdu, Sichuan, Peoples R China.
通讯机构：
[Liang, Fanrong] C;Chengdu Univ Tradit Chinese Med TCM, 37 Shi Er Qiao Rd, Chengdu, Sichuan, Peoples R China.
关键词：
ACUPUNCTURE
摘要：
To study whether a higher expectation of acupuncture measured at baseline and after acupuncture is associated with better outcome improvements in patients with migraine. We performed a secondary analysis of a previous published trial in which 476 patients with migraine were randomly allocated to three real acupuncture groups and one sham acupuncture control group. All the participants received 20 sessions of acupuncture over a 4-week period. The primary outcome was the number of days with a migraine attack (NDMA) assessed at 5-8 weeks after randomisation. The secondary outcomes were visual analogue scale, headache intensity and quality of life assessed at 4, 8 and 16 weeks after randomisation. Expectations of the acupuncture effect were assessed at baseline and at the end of treatment and categorised into five levels, with 0% the lowest and 100% the highest. Outcome improvement was first compared among the participants with different expectation levels using an analysis of variance model. The association between expectations of treatment and outcome improvement was then calculated using a logistic regression model. Patients with 100% baseline expectations did not report significantly fewer NDMA than those with 0% baseline expectations after adjusting for the covariates (at 5-8 weeks, 1.7 vs 3.9 days, p=0.987). High baseline expectations had no significant impact on improvement of the primary outcome (100% vs 0%: OR 8.50, 95% CI 0.89 to 191.65, p=0.682). However, patients with 100% post-treatment expectations reported fewer NDMA than those with 0% expectations (primary outcome: 1.3 vs 5.0 days, p<0.001) and were more likely to have a favourable response (100% vs 0%: OR 68.87, 95% CI 6.26 to 1449.73, p=0.002). Similar results were found when analysing the impact of expectation on the secondary outcomes. A high level of expectation after acupuncture treatment rather than at baseline was associated with better long-term outcome improvements in patients with migraine. NCT00599586. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
作者：
Ji, Binbin;Sun, Mei;Yi, Rongfang;Tang, Siyuan*
期刊：
Archives of Psychiatric Nursing,2014年28(5):319-326 ISSN：0883-9417
通讯作者：
Tang, Siyuan
作者机构：
[Ji, Binbin] Hunan Univ Chinese Med, Sch Nursing, Changsha, Hunan, Peoples R China.;[Ji, Binbin; Sun, Mei; Tang, Siyuan] Cent S Univ, Sch Nursing, Changsha, Hunan, Peoples R China.;[Yi, Rongfang] Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
通讯机构：
[Tang, Siyuan] C;Cent S Univ, Sch Nursing, Changsha, Hunan, Peoples R China.
摘要：
This quasi-experimental study aimed to determine the effectiveness of a multidisciplinary parent education program focused on improving health-related quality of life (HRQOL) for caregivers of children with autism spectrum disorders (ASD). This study included 42 participants (22 intervention, 20 wait-list control) who were the main caregivers of children with ASD. Data were collected at baseline and post-intervention. At the end of the multidisciplinary parent education program, significant improvements were observed in the mental HRQOL, family functioning, self-efficacy and positive coping style. The results indicate that a multidisciplinary parent education program, designed for caregivers of children with ASD, may have positive effects on caregivers' mental health-related quality of life, while having little effect on their physical health-related quality of life.
摘要：
We investigated the processing of self-related information under the prime paradigm using event-related potentials (ERPs) to provide evidence for implicit self-positivity bias in Chinese individuals. Reaction times and ERPs were recorded when participants made positive/negative emotional judgments to personality-trait adjectives about themselves or others. Faster responses occurred to self-related positive adjectives and other-related negative adjectives, indicating implicit self-positivity bias at the behavioral level. ERPs showed an interaction between prime and emotion at the P300 amplitude, with larger P300 amplitudes for words within the self-positivity bias, indicating that self-related information occupied more attentional resources. Larger N400 amplitudes elicited by words that were inconsistent with the self-positivity bias, suggesting that accessing non-self-relevant information is more difficult than self-relevant information. Thus, P300 and N400 could be used as neuro-indexes of the implicit self-positivity bias.
摘要：
Purposes: The purposes of this study were (1) to examine the level of structural empowerment, organizational commitment and job satisfaction in Chinese nurses; and (2) to investigate the relationships among the three variables. Background: A high turnover rate was identified in Chinese staff nurses, and it was highly correlated with lower job satisfaction. Structural empowerment and organizational commitment have been positively related to job satisfaction in western countries. Methods: A cross-sectional survey design was employed. Data analysis included descriptive statistics and multiple step-wise regression to test the hypothesized model. Results: Moderate levels of the three variables were found in this study. Both empowerment and commitment were found to be significantly associated with job satisfaction (r = 0.722, r = 0.693, p < 0.01, respectively). The variables of work objectives, resources, support and informal power, normative and ideal commitment were significant predictors of job satisfaction. Conclusions: Support for an expanded model of Kanter's structural empowerment was achieved in this study. (C) 2014 Elsevier Inc. All rights reserved.
期刊：
Journal of Community Health Nursing,2013年30(2):106-115 ISSN：0737-0016
通讯作者：
Liu, Yu
作者机构：
[Liu, Yu] Beijing Univ Chinese Med, Sch Nursing, Beijing, Peoples R China.;[Maier, Manfred] Med Univ Vienna, Ctr Publ Hlth, Vienna, Austria.;[Wu, Jihong; Hao, Yufang; Li, Wei; Chen, Yan] Beijing Univ Chinese Med, Beijing, Peoples R China.;[Qin, Yuelan] Peoples Hosp Hunan Prov, Changsha, Hunan, Peoples R China.;[Jin, Rongchen] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.
通讯机构：
[Liu, Yu] 6;6 Wangjingzhonghuannanlu, Beijing 100102, Peoples R China.
摘要：
The aim of this study was to assess the prevalence of depressive symptoms for patients with type-2 diabetes at the population level in China and explore differences in demographic, socioeconomic, and disease-specific parameters between diabetic patients with and without depression. Self-rating depression scale was used to screen for depressive symptoms in 667 patients with type-2 diabetes from 4 communities in Beijing; their quality of life and social support was assessed using appropriate and validated tools. The results indicate that 44.23% of diabetic patients report depressive symptoms; patients with depressive symptoms had a significantly higher rate of diabetic complications, a lower quality of life and less social support than patients without depressive symptoms.
