作者：
Hu Si-yuan;Zhou Yao;Zhong Sen-jie;Yang Meng;Huang Shu-min;...
期刊：
中国结合医学杂志,2023年29(2):119-126 ISSN：1672-0415
通讯作者：
Zhi-xi Hu
作者机构：
[Hu Si-yuan] Hunan Univ Chinese Med, Sch Sports Art, Changsha 410208, Peoples R China.;[Hu Si-yuan] Wuhan Sports Univ, Coll Hlth Sci, Wuhan 430079, Peoples R China.;[Zhou Yao] Hunan Tradit Chinese Med Coll, Dept Med, Zhuzhou 412012, Hunan, Peoples R China.;[Huang Shu-min; Yang Meng; Li Xin-chun; Li Lin; Zhong Sen-jie] Hunan Univ Chinese Med, Grad Sch, Changsha 410208, Peoples R China.;[Hu Zhi-xi] Hunan Univ Chinese Med, Inst Chinese Med Diag, Changsha 410208, Peoples R China.
通讯机构：
[Hu, Zhi-Xi] I;Institute of Chinese Medicine Diagnosis, Hunan University of Chinese Medicine, Changsha, 410208, China.
期刊：
Frontiers in Genetics,2023年13:3622 ISSN：1664-8021
作者机构：
[Chen, Yujing; Yang, Jing; Liu, Zixing; Li, Mengzhao] Guangzhou Univ Chinese Med, Clin Med Sch 1, Guangzhou, Peoples R China.;[Nie, Duorui] Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.;[Gong, Chun] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.;[Liu, Qiong] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China.
关键词：
lung cancer;Gastroesophageal reflux disease;Prospective analysis;causality;Mendelian randomization study
摘要：
Observational studies have suggested a positive association between gastroesophageal reflux disease and lung cancer, but due to the existence of confounders, it remains undetermined whether gastroesophageal reflux disease (GERD) has a causal association with lung cancer. Therefore, Mendelian randomization (MR) analyses were applied to investigate the relationship between the two conditions. Two-sample Mendelian randomization analysis was utilized with summary genetic data from the European Bioinformatics Institute (602,604 individuals) and International Lung Cancer Consortium, which provides information on lung cancer and its histological subgroups. Furthermore, we used two-step Mendelian randomization and multivariable Mendelian randomization to estimate whether smoking initiation (311,629 cases and 321,173 controls) and alcohol intake frequency (n = 462,346) mediate any effect of gastroesophageal reflux disease on lung cancer risk. The Mendelian randomization analyses indicated that gastroesophageal reflux disease was associated with and significantly increased the risk of lung cancer (ORIVW = 1.35, 95% CI = 1.18-1.54; p = 1.36 x 10(-5)). Smoking initiation and alcohol intake frequency mediated 35% and 3% of the total effect of gastroesophageal reflux disease on lung cancer, respectively. The combined effect of these two factors accounted for 60% of the total effect. In conclusion, gastroesophageal reflux disease is associated with an increased risk of lung cancer, and interventions to reduce smoking and alcohol intake may reduce the incidence of lung cancer.
作者机构：
[Yang, Xue-yuan; Guo, Chen-lu; Chen, Qi-hua] Hunan Univ Chinese Med, Dept Androl, Affiliated Hosp 1, Changsha 410007, Peoples R China.;[Yang, Xue-yuan] Hunan Univ Chinese Med, PostGrad Sch, Changsha 410208, Peoples R China.;[Cai, Wan-ling] Shanghai Univ Chinese Med, Shuguang Hosp, Dept Dermatol, Shanghai 201203, Peoples R China.
通讯机构：
[Chen, Qi-Hua] D;Department of Andrology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China.
关键词：
Chinese medicine;psoriasis vulgaris;molecular mechanism;network pharmacology;Chinese herbal medicine
摘要：
Psoriasis is a chronic skin disease and an important health concern. Western medicine and therapies are the main treatment strategies for psoriasis vulgaris (PV); however, the overall prognosis of patients with PV is still poor. Therefore, PV prevention is especially crucial. Chinese medicine (CM) has a long history of treating psoriasis, and it has unique wisdom in different cognitive angles and treatment modes from modern medicine. In this review, we first summarized the herbs and ancient CM formulas that have therapeutic effects on PV. Second, the research status and obstacles to the current development of CM in modern medicine were reviewed. Finally, the future of CM in the context of precision medicine and integrated medicine was discussed. After a detailed reading of the abundant literature, we believe that CM, through thousands of years of continuous development and clinical practice, has achieved high effectiveness and safety for PV treatment, despite its surrounding controversy. Moreover, precise analyses and systematic research methods have provided new approaches for the modernization of CM in the future. The treatment of PV with CM is worth popularizing, and we hope it can benefit more patients.
摘要：
BackgroundThere is growing evidence demonstrating that the gut microbiota plays a crucial role in multiple endocrine disorders, including diabetic cardiomyopathy (DCM). Research shows that the Chinese herb reduces disease occurrence by regulating gut microbiota. Zuogui Jiangtang Shuxin formula (ZGJTSXF), a Chinese medicinal formula, has been clinically used for treatment of DCM for many years. However, there is still no clear understanding of how ZGJTSXF treatment contributes to the prevention and treatment of DCM through its interaction with gut microbiota and metabolism. MethodsIn this study, mice models of DCM were established, and ZGJTSXF's therapeutic effects were assessed. Specifically, serum glycolipid, echocardiography, histological staining, myocardial apoptosis rate were assessed. Using 16s rRNA sequencing and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), we determined the impact of ZGJTSXF on the structure of gut microbiota and content of its metabolite TMAO. The mechanism of ZGJTSXF action on DCM was analyzed using quantitative real-time PCR and western blots. ResultsWe found that ZGJTSXF significantly ameliorated DCM mice by modulating gut-heart axis: ZGJTSXF administration improved glycolipid levels, heart function, cardiac morphological changes, inhibited cardiomyocytes apoptosis, and regulate the gut microbiota in DCM mice. Specifically, ZGJTSXF treatment reverse the significant changes in the abundance of certain genera closely related to DCM phenotype, including Lactobacillus, Alloprevotella and Alistipes. Furthermore, ZGJTSXF alleviated DCM in mice by blunting TMAO/PERK/FoxO1 signaling pathway genes and proteins. ConclusionZGJTSXF administration could ameliorate DCM mice by remodeling gut microbiota structure, reducing serum TMAO generation and suppressing TMAO/PERK/FoxO1 signaling pathway.
作者：
Zhi Wen;Yu-Yuan Wu;Gao-Yan Kuang;Jie Wen;Min Lu
期刊：
世界骨科杂志：英文版,2023年14(04):186-196 ISSN：2218-5836
作者机构：
Graduate School, Hunan University of Chinese Medicine;[Min Lu; Gao-Yan Kuang] Department of Joint Orthopedics, The First Hospital of Hunan University of Chinese Medicine;[Yu-Yuan Wu] Department of Pediatric Orthopedics, Traditional Chinese Medicine Hospital in Huaihua;[Jie Wen] Department of Pediatric Orthopedics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University;[Zhi Wen] Graduate School, Hunan University of Chinese Medicine<&wdkj&>Department of Joint Orthopedics, The First Hospital of Hunan University of Chinese Medicine
摘要：
Developmental dysplasia of hip seriously affects the health of children, and pelvic osteotomy is an important part of surgical treatment. Improving the shape of the acetabulum, preventing or delaying the progression of osteoarthritis is the ultimate goal of pelvic osteotomies. Re-directional osteotomies, reshaping osteotomies and salvage osteotomies are the three most common types of pelvic osteotomy. The influence of different pelvic osteotomy on acetabular morphology is different, and the acetabular morphology after osteotomy is closely related to the prognosis of the patients. But there lacks comparison of acetabular morphology between different pelvic osteotomies, on the basis of retrospective analysis and measurable imaging indicators, this study predicted the acetabular shape after developmental dysplasia of the hip pelvic osteotomy in order to help clinicians make reasonable and correct decisions and improve the planning and performance of pelvic osteotomy.
作者机构：
[Di Zhao; Ziyang Yi; Zhao Liu] Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;[Yan Wang] Husein Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Sindh 75270, Pakistan;[Ping Cai] Institute of Chinese Medicine Resources, Hunan Academy of Chinese Medicine, Changsha, Hunan 410013, China;[Wei He] Resgreen Biological Engineering Group Co., Ltd., Changsha, Hunan 410329, China;[Sharmeen Fayyaz] Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China<&wdkj&>Husein Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Sindh 75270, Pakistan
通讯机构：
[Ping Cai] I;[Wei He] R;Resgreen Biological Engineering Group Co., Ltd., Changsha, Hunan 410329, China<&wdkj&>Institute of Chinese Medicine Resources, Hunan Academy of Chinese Medicine, Changsha, Hunan 410013, China
摘要：
To investigate the metabolic trajectory of kidney aging and the effects of Polygonatum sibiricum polysaccharides (PSP) against kidney aging in D-galactose (D-gal)-induced aging mice, based on ultra-performance liquid chromatography/Q-Exactive Orbitrap mass spectrometry (UPLC-Q-Exactive MS/MS).
A total of 36 C57 BL/6J mice were randomly allocated to six groups: control (CON), model (MOD), PSP low-dose (PSP-L), PSP medium-dose (PSP-M), PSP high-dose (PSP-H), and positive drug ascorbic acid (VC) groups. To create models of aging mice, D-gal was intraperitoneally administered to all other groups of mice except the CON group. After modeling, the appropriate Chinese medicine [PSP-L: 150 mg/(kg·d), PSP-M: 300 mg/(kg·d), PSP-H: 600 mg/(kg·d)] or positive drug [ascorbic acid, 300 mg/(kg·d)] was administered for intervention. Key markers of renal function in urine and serum of mice in each group, such as creatinine (Crea), urea nitrogen (BUN), and uric acid (UA) levels, as well as key indicators of oxidative stress in serum and kidney, including superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) were determined to validate the successful establishment of kidney aging models and to estimate the effects of PSP. Hematoxylin and eosin (HE), periodic acid Schiff (PAS), and β-galactosidase staining were used to assess the renal pathological changes. The metabolic profiles of serum, kidney, and urine samples from CON, MOD, and PSP-H groups were analyzed by UPLC-Q-Exactive MS/MS, and pattern recognition methods were used to outline the metabolic trajectory of kidney aging and to identify the characteristic metabolites.
Age-related alterations in renal histopathology and impaired renal function in mice were also associated with oxidative stress indicators. Following the injection of PSP [PSP-H: 600 mg/(kg·d)], the pathological indices associated with aging were adjusted to normal levels, renal function and oxidative stress were improved in aging mice, and renal pathological damage was markedly improved. Meanwhile, the potential biomarkers were identified by UPLC-Q-Exactive MS/MS analysis and were further analyzed to form related metabolic pathways, with P < 0.05 as a threshold. The results showed that purine, sphingolipid, glycerophospholipid, tryptophan, and riboflavin metabolisms were the main metabolic pathways associated with aging. After administration of PSP, these pathological indices returned to normal levels, and biomarkers related to the aging process, such as adenosine monophosphate (AMP), tryptophan, and 5-hydroxytryptophan, also demonstrated, to some degree, reverse regulation (promoting synthesis).
Metabolomics methods based on UPLC-Q-Exactive MS/MS and multivariate statistical analysis can be adopted to establish metabolic profiles in aging mice. PSP has been shown to protect against kidney aging by interfering with the purine, sphingolipid, glycerophospholipid, tryptophan, and riboflavin metabolisms in the kidney.
作者机构：
湖南中医药大学研究生院,长沙410208;湖南省中医药研究院中药资源研究所,长沙410013;[张水寒; 刘晓柳; 金剑] Graduate School, Hunan University of Chinese Medicine, Changsha, 410208, China, Institute of Chinese Medicine Resources, Hunan Academy of Chinese Medicine, Changsha, 410013, China;[谢景; 谢珍妮; 钟灿] Institute of Chinese Medicine Resources, Hunan Academy of Chinese Medicine, Changsha, 410013, China
