作者机构：
[Wang, Shan-Shan] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.;[Ge, Jin-Wen] Hunan Univ Chinese Med, Dept Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.;[Cheng, Shao-Wu] Hunan Univ Chinese Med, Dept Cytobiol & Mol Biotechnol, Changsha 410208, Hunan, Peoples R China.
会议名称：
International Conference on Biological Sciences and Technology (BST)
会议时间：
JAN 08-10, 2016
会议地点：
Guangzhou, PEOPLES R CHINA
会议主办单位：
[Wang, Shan-Shan] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.^[Ge, Jin-Wen] Hunan Univ Chinese Med, Dept Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.^[Cheng, Shao-Wu] Hunan Univ Chinese Med, Dept Cytobiol & Mol Biotechnol, Changsha 410208, Hunan, Peoples R China.
摘要：
Coagulation factor XII (FXII) is a multidomain serine protease that is the starter of intrinsic coagulation pathway. FXII deficiency and clinical hemostasis are not associated with bleeding, so investigators have not considered FXII important in physiology for a long time. In seeking explanation for FXII-independent physiologic hemostasis, investigators found FXII is an essential constitute of contact system that mediates procoagulation and proinflammatory via the intrinsic coagulation pathway or the Kallikrein-kinin system, respectively. Date obtained in infectious inflammation have revealed FXII mediated clotting that limited bacterial or toxin spread in early phases, and regulated fibrinolysis in later. Moreover, FXII mediated two noninfectious inflammation Hereditary angioedema (HAE) and non-specific allergy via bradykinin (BK) formation. In the coagulation, thrombosis not only is involved with coagulation, but is redefined as thrombo-inflammatory disorder. This paper reviews in detail the progresses in roles of FXII intersection between inflammation and coagulation.
