针药结合治疗中风后抑郁临床疗效的Meta分析
作者:
周兰;邹开来;李丹;周巍;黎铭玉;...
期刊:
中医药导报 ,2021年27(02):133-138 ISSN:1672-951X
作者机构:
[钟欢; 周兰; 赵娟; 肖山峰; 黎铭玉; 周巍] 湖南中医药大学;[邹开来; 李丹] 浏阳市中医医院;[刘密] 湖南中医药大学<&wdkj&>浏阳市中医医院
关键词:
针药结合;中风后抑郁;脑卒中;抑郁症;随机对照试验;Meta分析
摘要:
目的:系统评价针药结合治疗中风后抑郁的安全性和有效性。方法:检索中国知网、维普、万方、PubMed、Embase、Medline数据库,由3名研究者对检索文献按照纳入标准进行筛选,对纳入文献进行数据提取、质量评价并记录其基本特征,用Cochrane手册5.1.0版本推荐的"偏倚风险评估"工具评估其偏倚风险,用RevMan 5.3进行Meta分析。结果:纳入26篇文献,共2 103例病例,文献的质量评价多为中等。Meta分析结果显示,试验组总有效率高于对照组[OR=3.38,95%CI(2.61,4.37),P<0.000 01,I~2=0%];试验组HAMD评分低于对照组[MD=-6.00,95%CI(-8.98,-3.03),P<0.000 1,I~2=99%];试验组NIHSS评分低于对照组[MD=-4.65,95%CI(-6.33,-2.98),P<0.000 01,I~2=96%];试验组Barthel评分高于对照组[MD=15.92,95%CI(9.79,22.06),P<0.000 01,I~2=93%]。结论:针药并用治疗中风后抑郁具有显著的疗效,但纳入文献的质量不高,仍需要更多高质量的多中心、大样本的临床研究来证明。
语种:
中文
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针刺对慢性萎缩性胃炎大鼠“足三里”穴区 HRH2、SP及炎性因子表达的影响
作者:
尹鸿智;赵娟;刘倩;金佳燕;常小荣;...
期刊:
湖南中医药大学学报 ,2021年41(02):259-264 ISSN:1674-070X
作者机构:
[常小荣; 钟欢; 尹鸿智; 赵娟; 刘倩; 金佳燕] 湖南中医药大学;浏阳市中医医院;[刘密] 湖南中医药大学<&wdkj&>浏阳市中医医院
关键词:
慢性萎缩性胃炎;针刺;组胺H2受体;P物质;炎性因子
摘要:
目的观察针刺对慢性萎缩性胃炎(chronic atrophic gastritis, CAG)大鼠及正常大鼠"足三里"穴区组胺H2受体(histamine H2 receptor, HRH2)、P物质(substance P, SP)及炎性因子(IL-6、IL-1β、TNF-α)的影响,并判断两者间是否存在差异。方法:将32只SD大鼠随机分为正常组、模型组、正常+针刺组和模型+针刺组,每组8只。采用1-甲基-3-硝基-1-亚硝基胍(1-methyl-2-nitro-1-nitrosoguanidine, MNNG)+乙醇灌胃+饥饱失常法建立大鼠CAG模型。针刺组每日治疗1次,每次20 min,连续针刺14 d。干预结束后,运用HE染色法观察胃组织病理学变化,运用免疫组化(immunohistochemistry, IHC)检测"足三里"局部穴区HRH2、SP、IL-6、IL-1β及TNF-α的表达。结果造模后胃组织病理形态改变显著,光镜下可见大量炎症细胞浸润,腺体萎缩且结构紊乱,纤维组织增生充填,并伴有散在出血点,符合CAG病理诊断标准。IHC染色IOD值显示,与正常组相比,模型组、正常+针刺组均能升高局部穴区HRH2表达(P<0.01);与模型组相比,模型+针刺组可以显著上调穴区组织SP表达(P<0.01)。对于炎性因子而言,与正常组相比,模型组均能上调IL-6、IL-1β、TNF-α表达(P<0.05或P<0.01),正常+针刺组可使IL-6表达上调(P<0.01);与模型组相比,模型+针刺组可以降低IL-6、IL-1β表达(P<0.05),而升高TNF-α表达(P<0.01)。结论针刺能对正常和CAG状态下大鼠"足三里"穴区HRH2、SP及炎性因子的表达产生影响,且所产生的生物学效应具有一定趋势,跟是否处于疾病状态有关。
语种:
中文
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野生与栽培夏枯草不同生长期3种酚酸成分含量动态研究
作者:
皮胜玲;郭小兰;刘密;李伟;刘湘
期刊:
中南药学 ,2021年19(01):100-104 ISSN:1672-2981
作者机构:
[刘密; 郭小兰; 刘湘; 李伟] 湘潭市中心医院药学部;湖南中医药大学药学院;[皮胜玲] 湘潭市中心医院药学部<&wdkj&>湖南中医药大学药学院
关键词:
夏枯草;野生;栽培;生长期;迷迭香酸;异迷迭香酸苷;咖啡酸
摘要:
目的通过研究野生与栽培夏枯草全草不同生长期的指纹图谱及3种酚酸成分含量动态变化规律,确定夏枯草全草的最佳采收期,研究全草的药用价值,并对野生与栽培夏枯草进行差异性比较。方法采用UPLC法测定野生与栽培夏枯草全草的指纹图谱及迷迭香酸、异迷迭香酸苷和咖啡酸的含量。结果夏枯草全草不同生长时期3种酚酸成分的含量差异较大;野生夏枯草与栽培夏枯草指纹图谱存在一定差异,3种酚酸成分含量差异不明显。结论夏枯草全草的最佳采收期在6月中上旬,野生与栽培夏枯草全草均具有一定的入药价值。
语种:
中文
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Cerebral fractional amplitude of low-frequency fluctuations may predict headache intensity improvement following acupuncture treatment in migraine patients
作者:
Li Zhengjie;Zhou Jun;Cheng Shirui;Lan Lei;Sun Ruirui;...
期刊:
中医杂志 ,2020年40(6):1041-1051 ISSN:1001-1668
通讯作者:
Zeng Fang;Liang, FR
作者机构:
[Liang Fanrong; Li Zhengjie; Gao Yujie; Zeng Fang; Zhou Jun; Cheng Shirui; Yang Jie; Lan Lei; Guo Taipin; Sun Ruirui] Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu 610000, Peoples R China.;[Liu Mailan] Hunan Univ Chinese Med, Acupuncture & Tuina Sch, Changsha 410000, Peoples R China.;[Gong Qi-yong] Sichuan Univ, West China Hosp, Huaxi Magnet Resonance Res Ctr, Chengdu 610000, Peoples R China.
通讯机构:
[Zeng, F; Liang, FR ] C;Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu 610000, Peoples R China.
关键词:
acupuncture;adult;amygdala;angular gyrus;Article;clinical outcome;controlled study;female;fractional amplitude of low-frequency fluctuation;functional magnetic resonance imaging;functional neuroimaging;hospital admission;human;major clinical study;male;middle frontal gyrus;middle temporal gyrus;migraine;nerve cell network;randomized controlled trial;rostral ventromedial medulla;superior temporal gyrus;thalamus;treatment response;young adult;brain;diagnostic imaging;headache;migraine;nuclear magnetic resonance imaging;treatment outcome;Acupuncture Therapy;Adult;Brain;Female;Headache;Humans;Magnetic Resonance Imaging;Male;Migraine Disorders;Treatment Outcome;Young Adult
摘要:
OBJECTIVE: To explore how baseline resting-state cerebral function predicts clinical outcomes of acupuncture treatment for migraine. METHODS: One hundred migraine patients and 46 healthy subjects were recruited. Patients were randomized into the acupuncture, sham acupuncture, and waiting list groups. Resting-state functional magnetic resonance imaging data were collected at baseline and after 1 month of longitudinal acupuncture treatments. Fractional amplitude of low-frequency fluctuations (fALFF) calculations were applied to explore the associations between baseline fALFF and changes in clinical variables in the acupuncture treatment group and the waiting list group. RESULTS: Compared with healthy subjects, migraine patients had lower fALFF in the left rostral ventromedial medulla, right thalamus, left amygdala, and right angular gyrus. Regression analyses revealed that baseline fALFF values in the left middle frontal gyrus, left superior temporal gyrus, and middle temporal gyrus were positively associated with headache intensity changes in the acupuncture treatment group, while baseline fALFF values in the bilateral lingual gyrus and cuneus were negatively associated with headache intensity changes in this group. CONCLUSION: The baseline fALFF values of brain regions associated with cognitive pain modulation, but not migraine severity, may predict future headache intensity improvement levels in migraine patients receiving acupuncture treatment. © 2020 JTCM. All rights reserved.
语种:
英文
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新型冠状病毒肺炎密切接触隔离人员灸法干预的意义与运行模式研究
作者:
刘迈兰;刘密;钟欢;郁洁;罗坚;...
期刊:
中国针灸 ,2020年40(5):457-461,471 ISSN:0255-2930
作者机构:
[刘密; 张泓; 钟欢; 罗坚; 刘迈兰; 艾坤; 刘琼; 郁洁; 许明; 常小荣] School of Acupuncture-Moxibustion and Tuina of Hunan University of CM, Changsha 410208, China;[戴国斌] Business School of Central South University;[章薇] First Affiliated Hospital of Hunan University of CM;[刘保延] China Academy of Chinese Medical Sciences, Beijing 100700
关键词:
新型冠状病毒肺炎;灸法;居家医学隔离;研究方案
摘要:
基于中医"未病先防"的理念,探索灸法干预新型冠状病毒肺炎(简称"新冠肺炎")密切接触隔离人员的模式与研究方案.以新冠肺炎密切接触居家隔离人员为研究对象,依托中国针灸学会、湖南省针灸学会和中国中医科学院数据中心与渔歌医疗公司开发的非接触式医患互动网络平台,设计一个探索性的随机对照试验,样本量100例,随机分为灸法组和常规组,每组50例.灸法组实施灸法干预,常规组只常规观察不进行灸法干预.以焦虑、情志不畅、乏力、头痛、腹泻等症状变化,是否解除隔离、确诊等为结局指标,评价两组患者干预前、干预14 d和干预后2周随访时的结果.研究将基于互联网+技术,采用互联网互动平台,通过手机微信完成研究对象的筛选、随机分组、灸法干预指导与患者日记卡的质量控制和数据收集.期望能够对新冠肺炎隔离人员灸法干预的意义以及实施的模式做出初步的评估.
语种:
中文
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Acupuncture and moxibustion for pain relief and quality of life improvement in patients with knee osteoarthritis: A protocol for systematic review and meta-analysis
作者:
Cheng, Shirui;Zhou, Jun;Xu, Guixing;Xin, Ming;Cheng, Ying;...
期刊:
MEDICINE ,2020年99(22):e20171 ISSN:1357-3039
通讯作者:
Liu, ML
作者机构:
[Cheng, Ying; Zhou, Jun; Zhou, Yuanfang; Qu, Yuzhu; Xu, Guixing; Cheng, Shirui] Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.;[Xin, Ming] Chengdu Fifth Peoples Hosp, Rehabil Dept, Chengdu, Sichuan, Peoples R China.;[Cheng, Ying] Cheng Clin Ltd, London, England.;[Qu, Yuzhu] Chengdu Univ Tradit Chinese Med, Affiliated Hosp 1, Chengdu, Sichuan, Peoples R China.;[Chang, Xiaorong; Liu, Mi; Liu, Mailan] Hunan Univ Chinese Med, Coll Acupuncture & Moxibust & Tuina, Changsha, Hunan, Peoples R China.
通讯机构:
[Liu, ML ] H;Hunan Univ Chinese Med, Coll Acupuncture & Moxibust & Tuina, Changsha, Hunan, Peoples R China.
关键词:
acupuncture;analgesia;human;knee osteoarthritis;meta analysis (topic);moxibustion;pathophysiology;procedures;quality of life;Acupuncture Therapy;Humans;Meta-Analysis as Topic;Moxibustion;Osteoarthritis, Knee;Pain Management;Quality of Life;Systematic Reviews as Topic
摘要:
Objective: The aim of this systematic review and meta-analysis is to assess the efficacy of acupuncture and moxibustion in pain relief and quality of life improvement of knee osteoarthritis (KOA) patients. Methods: The following databases will be searched: MEDLINE, EMBASE, the Cochrane Library, Web of Science, Chinese Biomedical Literature Database, Chinese Nation Knowledge Infrastructure, Wanfang Database, the Chongqing VIP from inception to May 1, 2020. All randomized controlled trials (RCTs) used acupuncture or moxibustion to relieve pain and improve quality of life (QoL) among KOA patients will be included. Study selection, data extraction, quality assessment and assessment of risk bias will be performed by 2 reviewers independently. Data synthesis will be performed using Review Manager V5.3 software. A meta-analysis will be performed when there is sufficient available data. PROSPERO registration number: CRD42020169724
语种:
英文
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基于艾灸温通理论探讨艾灸内关穴预处理对大鼠MIRI保护机制的研究
作者:
黄河;王晶;方园;刘密;常小荣;...
期刊:
湖南中医药大学学报 ,2020年40(09):1049-1053 ISSN:1674-070X
作者机构:
湖南中医药大学针灸推拿学院,湖南 长沙 410208;浏阳市中医医院,湖南 浏阳 410300;郴州市第一人民医院西院,湖南 郴州 423000;[冯芳] 湖南省郴州市第一人民医院;[常小荣; 黄河; 刘密; 方园; 王晶] 湖南中医药大学
关键词:
心肌缺血再灌注损伤;艾灸;温通理论;内关穴;保护机制
摘要:
目的 以心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)大鼠模型为实验对象,探讨艾灸温通效应对MIRI大鼠的预保护作用是否与心肌细胞中B细胞淋巴瘤/白血病-2(Bcl-2)、低氧诱导因子-1α(HIF-1α)及天冬氨酸特异性半胱氨酸蛋白酶-3(Caspase-3)的变化有关.方法 40只SD大鼠随机分为正常组、模型组、艾灸5 d组、艾灸10 d组,每组10只,各组按被试因素予以干预并取材,采用Western blot和RT-PCR分别检测心肌细胞中Bcl-2、HIF-1α、Caspase-3的表达和mRNA的表达.结果 与模型组相比,艾灸5 d组和艾灸10 d组大鼠心肌细胞中HIF-1α及Caspase-3的蛋白表达和mRNA表达显著降低(P<0.01或P<0.05),Bcl-2蛋白表达和mRNA表达显著增高(P<0.01);与艾灸5 d组相比,艾灸10 d组大鼠心肌细胞中Bcl-2蛋白表达显著增高(P<0.05),Caspase-3的蛋白表达显著降低(P<0.01),HIF-1α和Caspase-3的mRNA表达显著降低(P<0.01或P<0.05).结论 艾灸温通效应对心肌缺血再灌注所引起的心肌细胞损伤具有保护作用,其机制可能是通过降低MIRI大鼠心肌细胞中HIF-1α、Caspase-3的含量,增加心肌细胞中Bcl-2的含量,最终起到保护作用.
语种:
中文
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腧穴定位法探究
作者:
周兰;黎铭玉;周巍;肖山峰;赵娟;...
期刊:
湖南中医杂志 ,2020年36(12):111-112 ISSN:1003-7705
作者机构:
湖南中医药大学,湖南长沙,410208;浏阳市中医医院,湖南浏阳,410300;[周兰; 肖山峰; 赵娟; 周巍; 刘密; 黎铭玉] 湖南中医药大学
关键词:
腧穴定位法;手指同身寸;体表解剖标志法;简便取穴;二步定位法
摘要:
穴位是人体脏腑经络之气输注的部位,也是邪气所入侵之处.当邪气侵犯人体或脏腑经络气血功能失调引起脏腑病变时,均会在相应的腧穴发生病理反应.运用针刺或艾灸等作用于腧穴,可激发经气,调和脏腑,从而达到阴平阳秘、邪去正安的治疗作用.而临床中是否准确定位腧穴,直接关系到针灸治疗的疗效.经典的腧穴定位法包括手指同身寸、体表解剖标志法、骨度分寸定位法、简便取穴法,但均存在一定的不足,导致腧穴定位并非十分准确.笔者总结了另外四种定位法,包括二步定位法、穴位生物物理特性法、穴位效应特异性法、现代技术腧穴定位法,以期为今后理论研究与临床治疗提供思路.
语种:
中文
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Effect of moxibustion at sensitized-acupoints on quality of life in patients with chronic superficial gastritis [艾灸敏化态腧穴对慢性浅表性胃炎患者生存质量的影响]
作者:
黄河;冯芳;王晶;方园;刘密;...
期刊:
针灸推拿医学:英文版 ,2020年18(6):425-430 ISSN:1672-3597
通讯作者:
Xiao-rong Chang<&wdkj&>Hui Xie
作者机构:
[黄河; 王晶; 方园; 常小荣] School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, 410208, China;[冯芳; 谢辉] Chenzhou No. 1 People’s Hospital, Chenzhou, Hunan Province 423000, China;Liuyang Hospital of Chinese Medicine, Liuyang, Hunan Province 410300, China;[刘密] School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, 410208, China<&wdkj&>Liuyang Hospital of Chinese Medicine, Liuyang, Hunan Province 410300, China
通讯机构:
[Xiao-rong Chang] S;[Hui Xie] C;School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Chenzhou No. 1 People’s Hospital, Hunan Province, Chenzhou, China
关键词:
Moxibustion Therapy;Moxa Stick Moxibustion;Heat-sensitive Moxibustion;Gastritis, Superficial;Quality of Life;Propensity Score Matching;Cohort Study
摘要:
Objective: To compare the efficacy difference between moxibustion at sensitized-acupoints and non-sensitized-acupoints using the same group of acupoints. Methods: A total of 139 patients with chronic superficial gastritis were divided into a sensitized acupoint group (102 cases) and a non-sensitized acupoint group (37 cases) based on whether acupoint sensitization occurred. The SPSS version 19.0 statistical software propensity score matching function was used to balance the baseline data between the groups. Finally, 29 pairs of matched patients were included, namely 29 cases in the sensitized acupoint group and 29 cases in the non-sensitized acupoint group. Both groups were treated with moxibustion therapy. The treatment lasted for 30 min per time, and was performed every other day for 8 weeks. Changes in the traditional Chinese medicine (TCM) symptom score and the short-form 36-item health survey (SF-36) score in both groups were observed before and after treatment, as well as the clinical efficacy. Results: The covariates of age, course of disease, TCM symptom score and SF-36 score in the two groups were balanced after matching (all P<0.05). After treatment, the total effective rate was 100.0% in the sensitized acupoint group and 79.3% in the non-sensitized acupoint group. The difference in the total effective rate between the two groups was statistically significant (P<0.01). After treatment and at the 4-week follow-up, the TCM symptom scores in the sensitized acupoint group were significantly lower than those in the non-sensitized acupoint group (all P<0.01); the SF-36 scores in the sensitized acupoint group were significantly higher than those in the non-sensitized acupoint group (all P<0.01). Conclusion: With the same group of acupoints, the sensitized acupoints have a better therapeutic effect and long-term efficacy than the non-sensitized acupoints in the treatment of chronic superficial gastritis. © 2020, Shanghai Research Institute of Acupuncture and Meridian.
语种:
英文
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艾灸肺俞对哮喘模型大鼠气道炎症的影响
作者:
张国山;邱冉冉;潘江;张建;张驰;...
期刊:
针灸推拿医学:英文版 ,2020年18(3):165-173 ISSN:1672-3597
通讯作者:
Cheng-xi Wang<&wdkj&>Mi Liu
作者机构:
[张驰; 刘密] School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, 410208, China;[邱冉冉; 潘江] The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China;[张建; 王诚喜] Hengyang Hospital of Traditional Chinese Medicine, Hengyang, 421001, China;[张国山] School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, 410208, China<&wdkj&>Hengyang Hospital of Traditional Chinese Medicine, Hengyang, 421001, China
通讯机构:
[Cheng-xi Wang] H;[Mi Liu] S;Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China<&wdkj&>School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, China
关键词:
Moxibustion Therapy;Moxa Stick Moxibustion;Point, Feishu (BL 13);Asthma;Inflammation;Cytokines;Rats
摘要:
Objective: To observe the effect of moxibustion at Feishu (BL 13) on related inflammatory cells and inflammatory factors in the bronchoalveolar lavage fluid of asthma model rats, and to explore the mechanism of moxibustion in treating asthma. Methods: A total of 48 Sprague-Dawley (SD) rats were randomly divided into a normal group, a model group, a moxibustion group and a medication group, with 12 rats in each group. Except for the normal group, the rats in the other three groups were subjected to ovalbumin sensitization to stimulate the asthma. At the same time, rats in the moxibustion group received moxibustion at bilateral Feishu (BL 13), and rats in the medication group received dexamethasone by intragastric administration. Rats in the normal and the model groups only received the same fixation and normal saline by intragastric administration. After the interventions, the inspiratory resistance, the expiratory resistance, and the pulmonary compliance were measured for rats in each group; the numbers of the inflammatory cells in the bronchoalveolar lavage fluid were counted; the levels of the involved inflammatory factors in bronchoalveolar lavage fluid were detected; the pathological morphologies of the lung tissues were observed under light microscope. Results: After modeling, compared with the normal group, the rats in the model group showed obvious asthma attack-like response, significantly increased inspiratory resistance and expiratory resistance (both P<0.01), and significantly reduced pulmonary compliance (P<0.01); thickened tracheal wall and the narrowed tracheal lumen observed under the light microscope; infiltration of inflammatory cells and increased eosinophils in and around the tracheal wall; significantly increased total number of inflammatory cells and proportion of eosinophils in the bronchoalveolar lavage fluid (all P<0.01); significantly reduced levels of interleukin (IL)-10, IL-12 and interferon (IFN)-γ (all P<0.01), and significantly increased levels of IL-4, IL-5 and tumor necrosis factor (TNF)-α (all P<0.01) in the bronchoalveolar lavage fluid. After intervention, compared with the model group, rats in the moxibustion and the medication groups showed significantly reduced asthma-like reaction, pathological morphological damage of lung tissue, inspiratory resistance and expiratory resistance (all P<0.01); significantly increased pulmonary compliance (P<0.01); significantly reduced total number of inflammatory cells, proportion of eosinophils, levels of IL-4, IL-5 and TNF-α in the bronchoalveolar lavage fluid (P<0.05 or P<0.01), while significantly increased IL-12 and IFN-y levels (all P<0.01) in the bronchoalveolar lavage fluid; rats in the medication group also showed a significantly reduced IL-10 level in the bronchoalveolar lavage fluid (P<0.01); there was no statistically significant difference between the moxibustion and the medication groups (all P>0.05). Conclusion: Both moxibustion at Feishu (BL 13) and intragastric administration of dexamethasone can improve the asthma attack-like symptoms of ovalbumin-sensitized rats; regulating the inflammatory cell numbers and the inflammatory factor contents in the lung may be one mechanism of moxibustion in treating asthma. © 2020, Shanghai Research Institute of Acupuncture and Meridian.
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英文
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Effects of moxibustion and acupuncture at Zusanli (ST 36) and Zhongwan (CV 12) on chronic atrophic gastritis in rats
作者:
Liu Mi;Shen Jiacheng;Liu Caichun;Zhong Huan;Yang Qing;...
期刊:
中医杂志(英文版) ,2020年40(5):827-835 ISSN:0255-2922
通讯作者:
She, C;Yu, S
作者机构:
[Chang Xiaorong; Shu Wenna; Yang Qing; Liu Mi; Ma Mingzhu; Zhong Huan] Hunan Univ Chinese Med, Coll Acupuncture & Moxibust & Tui Na, Changsha 410208, Peoples R China.;[Liu Mi] Liuyang Hosp Chinese Med, Liuyang 410300, Peoples R China.;[Yang Zong-bao; Liu Caichun; Shen Jiacheng] Xiamen Univ, Dept Tradit Chinese Med, Dept Elect Sci, Xiamen 361005, Peoples R China.;[Dong Jiyang] Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China.;[Yu Shu] City Univ Hong Kong, Hong Kong 999077, Peoples R China.
通讯机构:
[She, C ] C;[Yu, S ] T;Changsha Eighth Hosp, Changsha Hosp Tradit Chinese Med, Changsha 410002, Peoples R China.;Tat Chee Ave, Hong Kong 999077, Peoples R China.
关键词:
3 hydroxybutyric acid;acetic acid;adenosine;adenosine phosphate;alanine;choline;creatine phosphate;creatinine;epidermal growth factor;epidermal growth factor receptor;ethanolamine;glutamic acid;glutamine;glutathione;glycerol;glycerophosphorylcholine;glycine;inosine;isoleucine;lactic acid;leucine;methylmalonic acid;mitogen activated protein kinase;nicotinamide adenine dinucleotide phosphate;phosphorylcholine;serine;uracil;uracil DNA glycosidase;uridine;valine;epidermal growth factor;epidermal growth factor receptor;acupuncture;animal experiment;animal model;animal tissue;Article;atrophic gastritis;chronic gastritis;controlled study;cytokine release;enzyme phosphorylation;gene expression regulation;histopathology;male;metabolic fingerprinting;moxibustion;nonhuman;protein expression;proton nuclear magnetic resonance;rat;stomach tissue;treatment outcome;Western blotting;zhongwan acupoint;zusanli acupoint;acupuncture point;animal;atrophic gastritis;genetics;human;metabolism;Sprague Dawley rat;Acupuncture Points;Acupuncture Therapy;Animals;Epidermal Growth Factor;ErbB Receptors;Gastritis, Atrophic;Humans;Male;Moxibustion;Rats;Rats, Sprague-Dawley;Treatment Outcome
摘要:
OBJECTIVE: To evaluate the effects of moxibustion and acupuncture of Zusanli (ST 36) and Zhongwan (CV 12) acupoints on chronic atrophic gastritis (CAG) in rats, and to study the mechanisms behind their actions. METHODS: Forty-four male Sprague-Dawley rats were induced with CAG by intragastric administration of 40% ethanol combined with free drinking of N-methyl-N'-nitro-N-nitrosoguanidine and irregular feeding for 12 weeks, followed by daily treatment with moxibustion or acupuncture for 2 weeks. Histopathologic examination, Western blotting of cytokines [epidermal growth factor (EGF), EGF receptor (EGFR), extracellular signal-regulated kinase (ERK), phosphorylated ERK (p-ERK)], and 1H NMR-based metabolic profiling of gastric tissues were used to measure changes related to CAG modeling and treatment. RESULTS: Moxibustion and acupuncture at Zusanli (ST 36) and Zhongwan (CV 12) each relieved CAG-induced abnormalities in histopathology and cytokine expression of ERK and p-ERK. Only moxibustion treatment regulated the expression of EGF and EGFR. Metabolites that were increased in gastric tissue by CAG induction (alanine, nicotinamide adenine dinucleotide phosphate, uracil DNA glycosylase, lactate, glycerol and adenosine) were restored to normal levels after moxibustion treatment; acupuncture treatment only normalized the levels of adenosine monophosphate and glycerol. CONCLUSION: Our findings suggest that moxibustion or acupuncture at Zusanli (ST 36) and Zhongwan (CV 12) can significantly improve the condition of CAG in rats. These treatments exert their effects on CAG through different mechanisms. © 2020 JTCM. All rights reserved.
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英文
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针刺与艾灸疗法的共性分析
作者:
欧阳里知;胡舒宁;刘密;刘迈兰;钟欢;...
期刊:
湖南中医药大学学报 ,2020年40(09):1077-1081 ISSN:1674-070X
作者机构:
湖南中医药大学,湖南 长沙 410208;浏阳市中医医院,湖南 浏阳 410300;郴州市第一人民医院西院,湖南 郴州 423000;[欧阳里知; 常小荣; 胡舒宁; 钟欢; 刘迈兰] 湖南中医药大学;[谢辉] 湖南省郴州市第一人民医院
关键词:
针刺;艾灸;文献研究;共性分析
摘要:
针刺与艾灸是在中医学基础理论指导下,防治疾病的两种特色外治疗法,常以针灸并称.通过阅读针灸古籍,结合近代针灸文献研究进展,探讨针刺与艾灸的共同点,从理论基础和治疗特性两方面总结共同点:同以体表刺激为特点、同以病理状态为条件、同以明证审穴为指导、同以标本兼顾为原则、同以攻补兼施为手段、同以疏通经脉为根本、同以调和气血为关键、同以平衡阴阳为目的.对针刺与艾灸相同点的研究对针灸的临床应用具有共性指导意义.
语种:
中文
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基于中医阴阳理论探讨针灸对细胞自噬的调节作用及意义
作者:
黎铭玉;周巍;周兰;艾坤;刘梨;...
期刊:
湖南中医药大学学报 ,2020年40(11):1427-1431 ISSN:1674-070X
作者机构:
湖南中医药大学针灸推拿学院,湖南 长沙 410208;湖南中医药大学第一附属医院,湖南 长沙 410007;浏阳市中医医院,湖南 浏阳 410300;[刘梨] 中医药大学第一附属医院;[艾坤; 周兰; 周巍; 刘密; 黎铭玉] 湖南中医药大学
关键词:
细胞自噬;针灸;阴阳理论;内环境稳态
摘要:
细胞自噬是近年来生物医学领域研究的热点问题,自噬既是人体诸多生理机能的参与者,又是多种疾病发展变化的风险因子。阴阳理论是中医最基本的理论学说之一,其追求阴阳平和的思想与自噬调控细胞内环境稳态的作用不谋而合。针灸可通过调和阴阳达到治愈疾病的目的,也能调控自噬的相关信号通路介导自噬的发生发展。本文尝试以中医阴阳理论为基础,探讨针灸对自噬的调节作用,为更深入地了解针灸与自噬的关系提供理论依据。
语种:
中文
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循经辨证取穴针刺治疗功能性消化不良:随机对照试验
作者:
刘红华;张国山;刘惠娟;李朵朵;刘密;...
期刊:
针灸推拿医学:英文版 ,2020年18(5):352-358 ISSN:1672-3597
通讯作者:
Xiao-rong Chang<&wdkj&>Mai-lan Liu
作者机构:
[刘红华; 张国山; 刘惠娟; 李朵朵; 刘密; 常小荣; 刘迈兰] Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构:
[Xiao-rong Chang; Mai-lan Liu] H;Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hunan University of Chinese Medicine, Changsha, China
关键词:
Acupuncture Therapy;Point Selection, Meridian;Point Selection Based on Syndrome Differentiation;Dyspepsia;Randomized Controlled Trial
摘要:
Objective: To observe the difference in clinical efficacy between acupuncture with point selection based on syndrome differentiation along the meridians and acupuncture at non-meridian and non-acupoint points for functional dyspepsia (FD). Methods: A total of 74 FD patients were randomized into an observation group and a control group, with 37 cases in each group. Both groups received acupuncture treatment. Zusanli (ST 36) and Neiguan (PC 6) were selected in the observation group, with Taichong (LR 3) and Neiting (ST 44) added for excess syndrome, and Gongsun (SP 4) and Yinlingquan (SP 9) added for deficiency syndrome. Four non-meridian and non-acupoint points were selected in the control group. The treatments in both groups were performed once a day with a 2-day break after 5 consecutive treatments, which constituted one treatment course. A total of 4 courses were performed. The scores of Nepean dyspepsia index (NDI) and Leeds dyspepsia questionnaire (LDQ) were recorded before and after treatment, and during follow-up (8, 12, 16, 20 and 24 weeks after recruitment) to assess the clinical efficacy. Results: The NDI scores in the two groups after treatment and at each time point during follow-up were higher than those before treatment (all P<0.05), and the LDQ scores were lower than those before treatment (all P<0.05). The NDI scores after treatment and at each time point during follow-up in the observation group were higher than those in the control group (all P<0.01); the total LDQ score and scores of upper abdominal pain, postprandial satiety and upper abdominal burning sensation after treatment and at each time point during follow-up in the observation group were significantly lower than those in the control group (P<0.01 or P<0.05). Conclusion: Acupuncture with point selection based on syndrome differentiation along the meridians has a better curative effect than acupuncture at non meridian and non-acupoint points in the treatment of FD. © 2020, Shanghai Research Institute of Acupuncture and Meridian.
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英文
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基于数据挖掘探讨穴位埋线治疗肥胖型多囊卵巢综合征的选穴规律
作者:
周兰;周巍;黎铭玉;赵娟;肖山峰;...
期刊:
河南中医 ,2020年40(11):1733-1737 ISSN:1003-5028
作者机构:
[周兰; 肖山峰; 赵娟; 周巍; 刘密; 黎铭玉] 湖南中医药大学;浏阳市中医院
关键词:
穴位埋线;多囊卵巢综合征;肥胖型;数据挖掘;天枢穴;关元穴;丰隆穴;三阴交穴;脾俞穴
摘要:
目的:系统收集并整理穴位埋线治疗肥胖型多囊卵巢综合征的文献,采用数据挖掘分析穴位埋线治疗肥胖型多囊卵巢综合征的选穴规律。方法:以"穴位埋线""肥胖型多囊卵巢综合征"为主题词检索中国知网、维普、万方和pubmed数据库,检索时间均为建库至2019年9月4日,初步纳入192篇文献,经剔除后纳入48篇文献。结果:选穴频次依次为:天枢、关元、丰隆、三阴交、脾俞。经脉频次依次为:足阳明胃经、任脉、足太阳膀胱经、足少阳胆经、足太阴脾经。特定穴中以交会穴、募穴、俞穴、五输穴、八会穴居多。取穴部位多集中于胸腹部和下肢。结论:穴位埋线治疗肥胖型多囊卵巢综合征常用穴位为天枢、关元、丰隆、三阴交、脾俞,主要集中在胃经、任脉、膀胱经上,穴位位于胸腹部和下肢。
语种:
中文
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A Preliminary Study on Quantitative Quality Measurements of the Urethral Rhabdosphincter Muscle by Supersonic Shear Wave Imaging in Women With Stress Urinary Incontinence
作者:
Zhao, Baihua;Wen, Lieming;Chen, Wenjie;Qing, Zhenzhen;Liu, Dan;...
期刊:
Journal of Ultrasound in Medicine ,2020年39(8):1615-1621 ISSN:0278-4297
通讯作者:
Wen, LM
作者机构:
[Wen, Lieming; Qing, Zhenzhen; Zhao, Baihua; Liu, Minghui; Liu, Dan] Cent South Univ, Xiangya Hosp 2, Changsha, Peoples R China.;[Chen, Wenjie] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.;[Wen, LM] Cent South Univ, Dept Ultrasound Diag, Xiangya Hosp 2, 139 Renmin Rd M, Changsha 410011, Hunan, Peoples R China.
通讯机构:
[Wen, LM ] C;Cent South Univ, Dept Ultrasound Diag, Xiangya Hosp 2, 139 Renmin Rd M, Changsha 410011, Hunan, Peoples R China.
关键词:
Muscle;Shear waves;Wave propagation;Linear transducers;Prospective study;Quality measurements;Shear wave imaging;Shear wave velocity;Spearman correlation coefficients;Stress urinary incontinences;Urethral sphincters;Shear flow;diagnostic imaging;elastography;female;human;male;muscle;prospective study;stress incontinence;urethra;Elasticity Imaging Techniques;Female;Humans;Male;Muscles;Prospective Studies;Urethra;Urinary Incontinence, Stress
摘要:
Objectives: To quantitatively assess the quality of the urethral rhabdosphincter muscle by measuring its shear wave velocity (Vs) and calculating the Young modulus (E) with supersonic shear wave imaging (SSI). Methods: This was a prospective study of 43 women with SUI and 52 female control participants who underwent a transperineal US examination with SSI. Supersonic shear wave imaging was performed at rest with a linear transducer and a specialized-preset procedure. The stability and validity of the shear waves were automatically assessed by the SSI procedure. The SSI images were visualized in a color-coded elastographic image. In the postprocessing analysis, the ventral part of the urethral rhabdosphincter muscle was manually outlined. The mean Vs and the mean E of the muscle were measured by the SSI procedure. The relationship between the mean Vs, mean E, and SUI was evaluated. Results: The SSI examination was successfully performed in 40 patients with SUI (93.0%) and 40 female control participants (76.9%). No significant differences between the groups in age, body mass index, and parity were identified. For the SUI and control groups, the mean Vs values were 2.54 and 2.73 m/s, respectively, and the mean E values were was 19.7 and 22.7kPa. Significant correlations were found between SUI and the mean Vs as well as the mean E (Spearman correlation coefficients, –0.41 and –0.43; P <.05). Conclusions: The mechanical properties of the urethral sphincter can be quantitatively assessed by SSI. The stiffness of the urethral rhabdosphincter muscle was significantly lower in women with SUI. © 2020 by the American Institute of Ultrasound in Medicine
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英文
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基于穴位敏化理论探讨敏化状态腧穴对膝关节骨性关节炎疗效的影响
作者:
黄河;王晶;方园;谭舒怀;曾理;...
期刊:
湖南中医药大学学报 ,2020年40(4):460-464 ISSN:1674-070X
作者机构:
湖南中医药大学针灸推拿学院,湖南长沙410208;浏阳市中医医院,湖南浏阳410300;[曾理; 谭舒怀; 常小荣; 黄河; 刘密; 方园; 王晶] 湖南中医药大学
关键词:
针灸;穴位敏化;膝关节骨性关节炎;队列研究
摘要:
目的本研究以膝关节骨性关节炎(knee osteoarthritis, KOA)患者为观察对象,针刺同一组腧穴,量化膝关节局部敏化态腧穴温度、压痛阈值,观察穴位敏化与穴位非敏化之间的疗效差异。方法 156例受试者依据是否符合敏化态腧穴诊断界值,分为穴位敏化组125例、穴位非敏化组31例。采用SPSS 19.0软件PSM功能均衡组间基线资料,最终纳入23对匹配患者,即穴位敏化组23例、穴位非敏化组23例。两组均采用针刺治疗,每次30 min,隔日1次,连续治疗4周。观察两组治疗前后及3个月后随访西安大略和麦克马斯特大学(western ontario and mcmaster universities, WOMAC)骨关节炎指数和健康调查12条简表(12-item short-form health survey, SF-12)评分情况。结果 (1)两组性别、年龄、病程、BMI指数、WOMAC评分、SF-12评分在组间不均衡的协变量经匹配后均达到均衡(P>0.05)。(2)治疗后,两组WOMAC评分均较治疗前显著降低(P<0.01),SF-12评分均较治疗前显著提高(P<0.01);且穴位敏化组的WOMAC评分低于穴位非敏化组(P<0.01),SF-12评分显著高于穴位非敏化组(P<0.01)。(3)随访时,穴位敏化组WOMAC评分依然显著低于穴位非敏化组(P<0.01),SF-12评分显著高于穴位非敏化组(P<0.01)。结论针刺同一组腧穴,穴位敏化组对KOA患者的临床疗效优于穴位非敏化组,为针灸临床治疗KOA提供进一步参考。
语种:
中文
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以教研室为单元的本科教学质量主要教学环节监控体系的研究实践
作者:
田浩梅;常小荣;王超;刘密;沈菁;...
期刊:
中国高等医学教育 ,2020年(03):63-64 ISSN:1002-1701
作者机构:
[陈楚淘; 沈菁; 常小荣; 田浩梅; 王超; 钟欢; 刘金芝; 刘密] 湖南中医药大学
关键词:
教研室单元;教学质量;主要教学环节;质量监控
摘要:
教学质量是高校可持续发展的决定因素,也是办好人民满意的高等教育、构建和谐社会的需要,更是建设创新型国家的需要。教研室为教学实施的基本单元,质量监控最小组织机构,其职责履行和成效直接影响教学质量。故以教研室为单元,立足学校及相关专业人才培养要求,结合教研室实际构建主要教学环节常态监控体系,提高本科人才培养质量。
语种:
中文
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Real-time assessment of the behaviour of the bladder neck and proximal urethra during urine leaking in the cough stress test (CST) in supine and standing positions using transperineal ultrasound
作者:
Wen, Lieming;Zhao, Baihua;Chen, Wenjie;Qing, Zhenzhen;Liu, Minghui
期刊:
International Urogynecology Journal ,2020年31(12):2515-2519 ISSN:0937-3462
通讯作者:
Liu, MH
作者机构:
[Wen, Lieming; Qing, Zhenzhen; Liu, MH; Zhao, Baihua; Liu, Minghui] Cent South Univ, Dept Ultrasound Diag, Xiangya Hosp 2, 139 Renmin Rd M, Changsha 410011, Hunan, Peoples R China.;[Chen, Wenjie] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.
通讯机构:
[Liu, MH ] C;Cent South Univ, Dept Ultrasound Diag, Xiangya Hosp 2, 139 Renmin Rd M, Changsha 410011, Hunan, Peoples R China.
关键词:
adult;aged;Article;bladder neck;body mass;controlled study;cough stress test;coughing;data analysis;data collection method;exercise test;female;human;major clinical study;pelvic organ prolapse;pelvis floor;physical activity;priority journal;prospective study;real time echography;renal system parameters;retrospective study;retrovesical angle;rotation;standing;stress incontinence;supine position;transperineal ultrasound;urethra;urethral funnelling;urethral length;urethral rotation angle;urine incontinence;bladder;coughing;diagnostic imaging;echography;exercise test;male;middle aged;stress incontinence;urethra;Cough;Exercise Test;Female;Humans;Male;Middle Aged;Prospective Studies;Retrospective Studies;Standing Position;Ultrasonography;Urethra;Urinary Bladder;Urinary Incontinence, Stress
摘要:
Introduction and hypothesis: The objective was to describe the behaviour of the bladder neck and proximal urethra during urine leaking in the cough stress test (CST) in supine and standing positions using transperineal ultrasound (TPUS). Method: We carried out prospective data collection and a retrospective data analysis of 102 women with stress urinary incontinence (SUI) who had a positive CST with TPUS in the supine and/or standing position. On TPUS, the behaviour of the bladder neck and proximal urethra was described by the urethral length, urethral funnelling, bladder neck descent (BND), retrovesical angle (RVA) and urethral rotation angle (URA). Differences between the ultrasound findings in the two positions were evaluated. Results: In the 102 women, the mean age was 48years and mean BMI was 23.8kg/m2. On TPUS, urine leakage was detected in the supine or standing position in 102 women and in both positions in 81. Between the two positions, significant differences were found in the URA and RVA. In the standing position, the median RVA of 166° was significantly larger than that of 133° in the supine position (p < 0.001), and the median URA of 35° was significantly smaller than that of 64° in the supine position (p < 0.001). Conclusions: TPUS in both positions can be used to detect the real-time behaviour of the bladder neck and urethra in the CST. In the standing position, less rotation and more straightening of the bladder neck and proximal urethra occurred during urine leakage. © 2020, The Author(s).
语种:
英文
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艾灸与针刺疗法的差异分析
作者:
方园;范丽红;黄河;钟欢;胡舒宁;...
期刊:
湖南中医药大学学报 ,2020年40(09):1070-1076 ISSN:1674-070X
作者机构:
湖南中医药大学针灸推拿学院,湖南 长沙 410208;浏阳市中医医院,湖南 浏阳 410300;[常小荣; 胡舒宁; 钟欢; 黄河; 范丽红; 刘密; 方园] 湖南中医药大学
关键词:
艾灸;针刺;文献研究;差异分析
摘要:
艾灸和针刺是中医学两种独立且具特色的外治疗法,艾灸为温热刺激,针刺则为机械刺激.通过分析古代文献,结合现代研究,从器、用、效、感、术、证6个方面分析艾灸与针刺疗法的不同,认为阴证、寒证、虚证、里证宜用灸法治疗,艾灸具有更好的温热效应及增强免疫的作用;阳证、热证、实证、表证多选用针刺疗法,针刺主要具有通经脉、调气血、和营卫作用,抗炎止痛效果更佳.临床应用时应从整体观念出发,辨证论治,因证择法,选择最佳的灸刺方案.
语种:
中文
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