通讯机构：
[Dong, JY; Yang, ZB] X;Xiamen Univ, Dept Elect Sci, Xiamen 361005, Peoples R China.;Xiamen Univ, Dept Tradit Chinese Med, Xiamen 361005, Peoples R China.
摘要：
Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficial treatment is yet to be established. In the present study, an integrated histopathological examination along with molecular biological assay, as well as 1H NMR analysis of multiple biological samples (urine, serum, stomach, cortex and medulla) were employed to systematically assess the pathology of CAG and therapeutic effect of electro-acupuncture stimulation at Sibai (ST 2), Liangmen (ST 21), and Zusanli (ST 36) acupoints located in the stomach meridian using a rat model of CAG. The current results showed that CAG caused comprehensive metabolic alterations including the TCA cycle, glycolysis, membrane metabolism and catabolism, gut microbiota-related metabolism. On the other hand, electro-acupuncture treatment was found able to normalize a number of CAG-induced metabolomics changes by alleviating membrane catabolism, restoring function of neurotransmitter in brain and partially reverse the CAG-induced perturbation in gut microbiota metabolism. These findings provided new insights into the biochemistry of CAG and mechanism of the therapeutic effect of electro-acupuncture stimulations.
作者机构：
[Qiong LIU; De-jun WANG; Jun-yun GE; Guo-shan ZHANG; Zhou YANG; Xiao-rong CHANG] College of Acupuncture & Moxibustion and Tuina, Hunan University of CM, Changsha 410007, Hunan;[Zong-bao YANG] Guoyitang, Medical College of Xiamen University, Changsha 410007, Hunan
摘要：
Objective To explore the clinical efficacy of tuina combined with moxibustion for treatment of lung-wei insecurity-type sweating syndrome in children. Methods Infantile tuina combined with moxibustion was conducted for 28 cases of lung-wei insecurity-type sweating syndrome in children. Tuina was carried out for once every other day, and moxibustion was conducted for once every other three days. Clinical efficacy was observed after treatment for 4 weeks. Results The total eff ective rate of tuina combined with moxibustion for treatment of lung-wei insecurity-type sweating syndrome in children was 92.85%. Conclusion The efficacy of tuina combined with moxibustion for treatment of lung-wei insecurity-type sweating syndrome in children is definite, which is worthy of being popularized clinically.
作者机构：
[Huan Zhong; Mai-lan Liu; Mi Liu; Xiao-rong Chang] School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, China;[Jian Xiong; Shan-shan Zuo; Zhi-ying Gao] Acupuncture-moxibustion Department, Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital), Changsha, China;[Chang She] School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Acupuncture-moxibustion Department, Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital), Changsha, China
通讯机构：
[Xiao-rong Chang] S;School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, China
摘要：
Objective: To observe the clinical effect of wheat grain-sized cone moxibustion combined with fire needle therapy in the treatment of dorsal wrist ganglion (DWG). Methods: A total of 63 patients with DWG were randomized into a treatment group (n=32) and a control group (n=31). Cases in the control group were treated with fire needle therapy. Based on the therapy given to the control group, cases in the treatment group were additionally given wheat grain-sized cone moxibustion therapy. Then the therapeutic efficacies and recurrence rate were evaluated. Results: After treatment, the overall effective rate was 93.8% in the treatment group, versus 77.4% in the control group, and the between-group comparison showed a statistical significance (P<0.05); 6 months after the treatment, the recurrence rate in the treatment group was obviously lower than that in the control group (P<0.05). Conclusion: The long-term and short-term effects of wheat grain-sized cone moxibustion combined with fire needle therapy in the treatment of DWG are better than those of fire needle therapy alone, and therefore, worth popularizing.
摘要：
Acupuncture is a traditional Chinese medicine therapy that has been found useful for treating various diseases. The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian specificity). This study aims to investigate the metabolic basis of meridian specificity using proton nuclear magnetic resonance ((1)H NMR)-based metabolomics. Electro-acupuncture (EA) stimulations were performed at acupoints of either Stomach Meridian of Foot-Yangming (SMFY) or Gallbladder Meridian of Foot-Shaoyang (GMFS) in healthy male Sprague Dawley (SD) rats. (1)H-NMR spectra datasets of serum, urine, cortex, and stomach tissue extracts from the rats were analysed by multivariate statistical analysis to investigate metabolic perturbations due to EA treatments at different meridians. EA treatment on either the SMFY or GMFS acupoints induced significant variations in 31 metabolites, e.g., amino acids, organic acids, choline esters and glucose. Moreover, a few meridian-specific metabolic changes were found for EA stimulations on the SMFY or GMFS acupoints. Our study demonstrated significant metabolic differences in response to EA stimulations on acupoints of SMFY and GMFS meridians. These results validate the hypothesis that meridian specificity in acupuncture is detectable in the metabolome and demonstrate the feasibility and effectiveness of a metabolomics approach in understanding the mechanism of acupuncture.
