摘要：
Objective: To observe the effect of tablet Yangxintongmai on atherosclerosis( AS) rats. Methods: 72 Wistar rats were divided into four groups, i.e. normal, model, control and therapy group. The AS model of rats was made by feeding with high grease food and AS plague was observed in the aorta after one month of feeding. Tablet Yangxintongmai was used in the group of therapy; tablet Gypenosides was used in the group of control. The level of serum lipid, blood sugar and insulin were tested after one month; the change of aorta histology was observed by HE staining; the ultrastructure of aorta tissue was observed by transmission electronic microscope; the apoptosis of aorta vascular smooth muscle (VSMC) and the expression of actin were evaluated by immunocytochemistry; the expression of VSMC genes such as c-myc, c-fos, PDGF-A, P53, bcl-2 mRNA were tested by RT-PCR. Results: In the therapy group, the level of TC, TG, plasmviscosity, erythrocyte hematocrit and platelet adhesion ratio(P < 0.05)decreased significantly; the level of HDL (P< 0.01), insulin sensitivity index increased; the plague regressed; the histology of aorto didn't change much; the expression of actin decreased; the gene expression of c-myc, PDGF-A, bcl-2(P < 0.05) were downregulated and P53(P < 0.05) was upregulated. Compared with the model group, the expression of c-fos mRNA was downregulated in the therapy group(P < 0.05). Conclusion: Tablet Yangxintongmai has significant effect on AS and the therapeutic molecular mechanism is inhibition of apoptosis and adjustment of the correlated gene expression.
