作者机构：
[张珂胜; 陈凌波; 邓常清; 黄小平] Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha 410208, China
摘要：
Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis. Following establishment of the model, mice were administered with Astragalus (6.00 g.kg(-1)), Angelica (3.00 g.kg(-1)), and combinations of Astragalus and Angelica at different ratios, including 10 : 1 (Astragalus 9.81 g.kg(1)+Angelica 0.98 g.kg(-1)), 5 : 1 (Astragalus 9.00 g.kg(-1)+Angelica 1.80 g.kg(-1)), 2 : 1 (Astragalus 7.71 g.kg(-1)+Angelica 3.08 g.kg(-1)), 1 : 1 (Astragalus 5.40 g.kg(-1)+Angelica 5.40 g.kg(-1)), 1 : 2.5 (Astragalus 3.08 g.kg(-1)+Angelica 7.71 g.kg(-1)), 1 : 5 (Astragalus 1.80 g.kg(-1)+Angelica 9.00 g.kg(-1)), and 1 : 10 (Astragalus 0.98 g.kg(-1)+Angelica 9.81 g.kg(-1)). Our results suggested that Astragalus mixed with Angelica synergistically promoted hematopoiesis best when the combination ratio of Astragalus and Angelica was 1 : 1, 1 : 2.5 or 1 : 5; moreover, the effect of Angelica was greater than that of Astragalus. The potential mechanisms of the combinations of Astragalus and Angelica that promote hematopoiesis include the dissolution of the effective components, promoting the synthesis and secretion of hematopoietic growth factor (HGF) and the proliferation of hematopoietic progenitor cells (HPCs).
作者机构：
[LIU Xiao-dan; DING Huang; LI Jing-xian; YANG Xiao-qian; TANG Biao; LI Ling; TANG Ying-hong; DENG Chang-qing; HUANG Xiao-ping] Molecular Pathology Laboratory,Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-Cerebral Diseases,Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques,Hunan University of Chinese Medicine
会议名称：
2016年国际生理学学术大会
会议时间：
2016-09-25
会议地点：
中国北京
摘要：
AIM: To probe the effect of Astragaloside IV and Ginsenoside Rg1 on autophagy injury of PC12 cell induced by oxygen glucose deprivation/reoxygenation(OGD/R),as well as their interactions.METHODS: The
作者机构：
[陈凌波; 张珂胜; 邓常清; 黄小平] Molecular Pathology Laboratory, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Deng, C.-Q.] M;Molecular Pathology Laboratory, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China
作者机构：
[DING Huang; LI Jing-xian; YANG Xiao-qian; TANG Biao; LIU Xiao-dan; TANG Ying-hong; DENG Chang-qing; HUANG Xiao-ping] Molecular Pathology Laboratory,Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-Cerebral Diseases,Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques,Hunan University of Chinese Medicine
会议名称：
2016年国际生理学学术大会
会议时间：
2016-09-25
会议地点：
中国北京
摘要：
AIM: To probe the effects and the mechanism of Astragaloside IV and Ginsenoside Rg1 on autophagy of PC12 cell induced by oxygen glucose deprivation/reoxygenation(OGD/R).METHODS: The autophagy injury m
作者机构：
[Chang-qing Deng; Xiao-ping Huang] Molecular Pathology Laboratory, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China;[Huang Ding; Ying-hong Tang] Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-cerebral Diseases, Changsha 410208, Hunan Province, China;[Bing-xiang Deng; Jin-dong Lu] Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques, Changsha 410208, Hunan Province, China;[Chang-qing Deng] E-mail: dchangq@sohu.com
关键词：
autophagy;brain ischemia;drugs, Chinese herbal;medicine, traditional Chinese;review
摘要：
Autophagy is a lysosome-mediated degradation process for non-essential or damaged cellular constituents, playing an important homeostatic role in cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in tumors as well as neurodegenerative, cardiovascular and cerebrovascular diseases. Recently, active compounds from traditional Chinese medicine (TCM) have been found to modulate the levels of autophagy in tumor cells, nerve cells, myocardial cells and endothelial cells. Ischemic stroke is a major cause of neurological disability and places a heavy burden on family and society. Regaining function can significantly reduce dependence and improve the quality of life of stroke survivors. In healthy cells, autophagy plays a key role in adapting to nutritional deprivation and eliminating aggregated proteins, however inappropriate activation of autophagy may lead to cell death in cerebral ischemia. This paper reviews the process and the molecular basis of autophagy, as well as its roles in cerebral ischemia and the roles of TCM in modulating its activity.
作者机构：
[邓常清; 欧阳国; 唐映红; 丁煌; 黄小平] Molecular Pathology Laboratory, Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-Cerebral Diseases, Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques, Changsha, 410208, China
通讯机构：
[Deng, C.-Q.] M;Molecular Pathology Laboratory, Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-Cerebral Diseases, Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques, Changsha, China
作者机构：
[丁煌; 黄小平] Molecular Pathology Laboratory, Key Lab. of Hunan Prov. for Prev. and Treatm. of Intgd. Traditional Chinese and W. Med. on Cardio-Cerebr. Dis., Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques, Hunan University of Chinese Medicine, Changsha, 410208, China;[唐映红] Dept. of Pharmacology in Pharmacy College, Hunan University of Chinese Medicine, Changsha, 410208, China
