关键词：
College students;Network analysis;Non-suicidal self-injury;Suicide
摘要：
BACKGROUND: Non-suicidal self-injury (NSSI) and suicide are a serious health concern in young people. Remarkable progress has been made in understanding the correlates and risk factors for suicidality. However, it remains unclear the complex interplay between different factors and which factors are most saliently associated with NSSI and suicide risk and should be targeted for interventions. METHODS: This study utilized network analysis to examine the interrelationship between NSSI, suicide and a variety of psychological (e.g., depression, psychotic-like experiences) and psychosocial (e.g., childhood maltreatment, family dysfunction, being bullied and social support) correlates in a sample of Chinese first year college students (n=2328). RESULTS: The severity of depressive symptoms was the only factor connected to both NSSI and suicide. Other psychiatric factors like psychotic experiences could only act in an indirect way via the bridging effect of depression. Emotional abuse, compared with other forms of childhood adversities, was found to be the most influential maltreatment form associated with suicidal ideation and attempts. Finally, social support showed the potential to lower the risk of self-injury and suicide in young people. LIMITATIONS: Only a subset of risk and resilience factors of NSSI and suicide were included. Causal inference was impossible due to the cross-sectional design. CONCLUSIONS: Our findings highlighted the importance of identifying risk groups with mental illnesses or negative childhood events, and providing additional support during the key time of transitioning into higher education.
期刊：
OMEGA - Journal of Death and Dying,2023年 ISSN：0030-2228
作者机构：
[Lv, Tingting] Hunan Univ Chinese Med, Sch Nursing, Changsha, Peoples R China.;[Zhang, Huilin; Wang, Huiping; Chen, Fengzhi; Lv, Tingting; Li, Lezhi; He, Xiachan; Zhao, Hong] Cent South Univ, Xiangya Hosp 2, Clin Nursing Teaching & Res Sect, Changsha, Peoples R China.;[Zhang, Huilin] Cent South Univ, Clin Nursing Teaching & Res Sect, Xiangya Hosp 2, 139 Renmin Middle Rd, Changsha, Peoples R China.
关键词：
coping with death;death cognition;meaning in life;Chinese traditional culture;nurses
摘要：
To explore nurses' ability to cope with death and its relationship with death cognition and meaning in life in the context of Chinese traditional culture. 1146 nurses from six tertiary hospitals were recruited. Participants completed the Coping with Death Scale, the Meaning in Life Questionnaire, and the self-made Death Cognition Questionnaire. Multiple regression analysis revealed that the search for meaning, the understanding of "good death", receiving education related to life-and-death, cultural aspect, the presence of meaning, and the number of patient deaths experienced in career explained 20.3% of the variance in the ability to cope with death. Lacking a correct understanding of death, nurses are not sufficiently prepared to deal with death and their ability to cope with death is influenced by the unique cognition of death and the sense of the meaning in life in the context of Chinese traditional culture.
摘要：
Metabolic syndrome (MetS) has the largest global burden of all noncommunicable diseases. Owing to the clinical heterogeneity of MetS, wide variations have been reported in the efficacy of moderate-to-vigorous physical activity (MVPA) and intermittent fasting (IF) for improving MetS. We searched five databases for randomized controlled trials published through December 2021, and 372 participants from 11 studies were included in this meta-analysis. Compared with MVPA alone, IF combined with MVPA had a more significant effect on improving body mass and levels of fasting blood glucose and high-density lipoprotein cholesterol; however, it was ineffective in improving triglycerides level, systolic blood pressure, and diastolic blood pressure. Subgroup analysis showed that, except for blood pressure, time-restricted fasting combined with MVPA had a better effect than alternate-day fasting with MVPA. Meanwhile, when the intervention lasted longer than 8 weeks, the effect of the combined intervention was significantly better than that of MVPA alone. This finding provides a basis for clinicians to manage the health of overweight individuals. This study also showed that Caucasians may be more suitable for the combined intervention than Asians. And the combined intervention may provide a preventive effect for MetS risk factors in healthy populations, although this may be due to the small sample size. In general, this study provides a novel perspective on special interventions for MetS traits.
期刊：
Human Resources for Health,2023年21(1):1-10 ISSN：1478-4491
通讯作者：
Feng, ZL;Cheng, J
作者机构：
[Huang, Yuting; Zhang, Huilin; Zou, Ying; Qin, Zuming] Cent South Univ, Second Xiangya Hosp, Clin Nursing Teaching & Res Sect, Changsha, Hunan, Peoples R China.;[Huang, Yuting; Qin, Zuming] Cent South Univ, Xiangya Sch Nursing, Changsha, Hunan, Peoples R China.;[Zou, Ying] Hunan Univ Chinese Med, Sch Nursing, Changsha, Hunan, Peoples R China.;[Feng, Zhiling; Cheng, Jiao; Feng, ZL] Cent South Univ, Second Xiangya Hosp, Changsha, Hunan, Peoples R China.
通讯机构：
[Feng, ZL ; Cheng, J ] C;Cent South Univ, Second Xiangya Hosp, Changsha, Hunan, Peoples R China.
关键词：
Health care workers;Turnover intention;Professional happiness;Meaning in life;Positive psychology;Health human resources
摘要：
The turnover and shortage of health care workers (HCWs) have been a worldwide problem for healthcare organizations. The primary aim of this study was to identify the factors influencing the intention of Chinese HCWs to leave their job, especially meaning in life and professional happiness. This observational cross-sectional study, conducted among 1125 full-time HCWs, assessed demographic variables, meaning in life, professional happiness, and turnover intention by a survey. The survey was distributed to HCWs in three tertiary hospitals. The data were analyzed by T-tests, ANOVA, Kruskal–Wallis tests and hierarchical linear regression model. There were statistically significant differences in turnover intention of HCWs by gender, age, role, educational level, years in practice, and number of monthly night shifts. HCWs’ meaning in life and professional happiness were negatively associated with the turnover intention. Furthermore, after controlling for other factors, meaning in life explained 3.7% of the turnover intention and professional happiness explained 13.4%. In our study, positive psychological factors were related to turnover intentions. Professional happiness was the strongest predictor. Thus, health human resource managers should foster positive psychology among HCWs to reduce their turnover.
通讯机构：
[Luo, YH ] H;Hunan Univ Chinese Med, Dept Appl Psychol, Changsha, Hunan, Peoples R China.
关键词：
mobile phone addiction;life events;boredom proneness
摘要：
PURPOSE: Mobile phone addiction has motivated a widespread concern in recent years. From a developmental perspective, this study explored the predictive relations between life events, boredom proneness (BP), and mobile phone addiction tendency (MPAT) among undergraduate students. It also tested the longitudinal mediation of BP between life events and MPAT. METHODS: Five hundred and eighty-four undergraduate students completed the Mobile Phone Addiction Tendency Scale, the Adolescent Self-Rating Life Events Checklist, and the Boredom Proneness Scale-Short Form. A longitudinal mediation analysis based on latent growth modeling was conducted to test the hypothesized relationships among life events, BP and MPAT. RESULTS: Latent growth modeling (LGM) showed that the BP and MPAT of undergraduate students both increased linearly. A longitudinal model based on LGM showed that negative life events both directly and indirectly affected the initial level and the growth rate of the MPAT through the mediating effect of the initial level of BP. CONCLUSION: These results reveal that negative life events are an indicator of the development of MPAT. It has practical implications for calling for adopting health coping styles when facing negative life events. Supported for reducing college students' boredom proneness in order to lessen the tendency towards mobile phone addiction to improve their mental health.
期刊：
Frontiers in Psychiatry,2023年14 ISSN：1664-0640
通讯作者：
Lv, ZP
作者机构：
[Xie, Shuwen; Lv, Zhiping; Huang, Sha; Kuang, Shanshan; Xia, Ting; Zhou, Chuying; Wang, Yuhua; Chen, Qing; Lv, ZP] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China.;[Bi, Yanmeng] Jining Med Univ, Coll Integrated Tradit Chinese & Western Med, Jining, Peoples R China.;[Yan, Weixin] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China.;[Wu, Shuhui] Hunan Univ Chinese Med, Affiliated Hosp 2, Changsha, Peoples R China.;[Kong, Wen] Guangzhou Hosp Integrated Chinese & Western Med, Guangzhou, Peoples R China.
通讯机构：
[Lv, ZP ] S;Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China.
关键词：
major depressive disorder;voxel-mirrored homotopic connectivity;support vector machine;functional magnetic resonance imaging;resting-state
摘要：
ObjectiveTo explore the interhemispheric information synergy ability of the brain in major depressive disorder (MDD) patients by applying the voxel-mirrored homotopic connectivity (VMHC) method and further explore the potential clinical diagnostic value of VMHC metric by a machine learning approach.Methods52 healthy controls and 48 first-episode MDD patients were recruited in the study. We performed neuropsychological tests and resting-state fMRI scanning on all subjects. The VMHC values of the symmetrical interhemispheric voxels in the whole brain were calculated. The VMHC alterations were compared between two groups, and the relationship between VMHC values and clinical variables was analyzed. Then, abnormal brain regions were selected as features to conduct the classification model by using the support vector machine (SVM) approach.ResultsCompared to the healthy controls, MDD patients exhibited decreased VMHC values in the bilateral middle frontal gyrus, fusiform gyrus, medial superior frontal gyrus and precentral gyrus. Furthermore, the VMHC value of the bilateral fusiform gyrus was positively correlated with the total Hamilton Depression Scale (HAMD). Moreover, SVM analysis displayed that a combination of all clusters demonstrated the highest area under the curve (AUC) of 0.87 with accuracy, sensitivity, and specificity values of 86.17%, 76.74%, and 94.12%, respectively.ConclusionMDD patients had reduced functional connectivity in the bilateral middle frontal gyrus, fusiform gyrus, medial superior frontal gyrus and precentral gyrus, which may be related to depressive symptoms. The abnormality in these brain regions could represent potential imaging markers to distinguish MDD patients from healthy controls.
作者机构：
[He, Shijia; Zhang, Huilin; Wang, Huiping; Chen, Fengzhi; Lv, Tingting; Li, Lezhi; Zhao, Hong] Cent South Univ, Xiangya Hosp 2, Clin Nursing Teaching & Res Sect, Changsha, Hunan, Peoples R China.;[He, Shijia; Chen, Fengzhi] Cent South Univ, Xiangya Sch, Nursing Sch, Changsha, Hunan, Peoples R China.;[Lv, Tingting] Hunan Univ Chinese Med, Sch Nursing, Changsha, Hunan, Peoples R China.
通讯机构：
[Li, L.] X;[Zhang, H.] C;Clinical Nursing Teaching and Research Section, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
关键词：
Perception of death;Competence to cope with death;Attitude toward death;Meaning of life;Mediating effects;Nursing;Death education
摘要：
It is important to understand how the perception of death affects the competence to cope with death. To explore whether the perception of death has an indirect effect on competence to cope with death through the mediation of attitude toward death and meaning of life. A total of 786 nurses from Hunan Province, China, selected by random sampling method and asked to complete an online electronic questionnaire between October and November 2021 were included in the study. The nurses’ scored 125.39 ± 23.88 on the competence to cope with death. There was a positive correlation among perception of death, competence to cope with death, the meaning of life, and attitude toward death. There were three mediating pathways: the separate mediating effect of natural acceptance and meaning of life, and the chain mediating effect of natural acceptance and meaning of life. The nurses’ competence to cope with death was moderate. Perception of death could indirectly and positively predict nurses’ competence to cope with death by enhancing natural acceptance or sense of meaning in life. In addition, perception of death could improve natural acceptance and then enhance the sense of meaning in life to positively predict nurses’ competence to cope with death.
作者机构：
[Ong, Marilyn Li Yin; Zhu, Zhenggang] Univ Sains Malaysia, Sch Hlth Sci, Exercise & Sports Sci Programme, Kubang Kerian, Kelantan, Malaysia.;[Pan, Xiaoyan] Hunan Univ Chinese Med, Sch Nursing, Changsha, Hunan, Peoples R China.;[Zhong, Faping] First Hosp Changde City Tradit Chinese Med, Dept Resp Med, Changde, Hunan, Peoples R China.;[Tian, Jun] Cent South Univ, Dept Geriatr Med, Xiangya Hosp, Changsha, Hunan, Peoples R China.;[Ong, Marilyn Li Yin] Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England.
通讯机构：
[Marilyn Li Yin Ong] E;Exercise and Sports Science Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia<&wdkj&>School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, UK
关键词：
Baduanjin;COVID-19;exercise;rehabilitation
摘要：
AIM: To understand Baduanjin rehabilitation therapy in mild COVID-19 patients. DESIGN: A narrative review. METHODS: A literature search for COVID-19 and Baduanjin treatments was conducted on Chinese and English electronic databases: China National Knowledge Infrastructure, Wanfang Data, Embase, PubMed, Scopus, Science Direct, Ebscohost, SPORTDiscus and ProQuest. RESULTS: Twelve studies on the Baduanjin rehabilitation for COVID-19 patients have been included. We acknowledged the considerable published research and current clinical practice using Baduanjin for COVID-19 treatment in the following areas: anxiety, depression, insomnia, lung function rehabilitation, immunity and activity endurance. CONCLUSION: The use of Baduanjin as adjuvant therapy for COVID-19 patients' rehabilitation is still limited, therefore, more clinical studies are needed to confirm its efficacy.
期刊：
Frontiers in Psychiatry,2023年14 ISSN：1664-0640
作者机构：
[Chang, Hongming; Meng, Xiaolu; Li, Chunlu; Li, Yaqi] Guizhou Med Univ, Sch Med Humanitarians, Dept Psychol, Guiyang, Peoples R China.;[Meng, Xiaolu; Li, Chunlu] Guizhou Hlth Dev Res Ctr, Guiyang, Peoples R China.;[Yuan, Wen; Liu, Jiaxi; Ni, Jian] Hunan Univ Chinese Med, Dept Appl Psychol, Changsha, Peoples R China.
关键词：
mindfulness;social media addiction;attention control;fear of missing out;college students
摘要：
IntroductionThe COVID-19 pandemic has exacerbated social media addiction (SMA), making it urgent to find effective interventions for social media addiction. Evidence has shown that mindfulness might be an effective intervention for social media addiction. However, psychological mechanisms by which mindfulness reduce social media use remain unclear. Here, we further addressed this issue to examine whether attentional control and fear of missing out (FOMO) mediate the relationship between mindfulness and SMA. MethodsWe recruited 446 college students from two universities in China and analyzed the data. ResultsThe results suggest that there are mediation effects of attentional control and FOMO between mindfulness and SMA through 3 paths: path 1, mindfulness -> attention control -> SMA (-0.04); path 2, mindfulness -> FOMO -> SMA (-0.22); and path 3, mindfulness -> attention control -> FOMO -> SMA (-0.05). DiscussionTherefore, mindfulness-based interventions may be an effective way to alleviate social media addiction, especially mindfulness-based interventions targeting FOMO. At the end of the article, we also discussed the limitations of this study.
摘要：
INTRODUCTION: Travel and living environment restrictions, which may have positive or negative effects on smoking-related behaviors, were implemented to limit the COVID-19 pandemic. This study aimed to compare the baseline clinical characteristics and smoking cessation (SC) rate at 3 months of patients in an SC clinic in Hunan Province, China before and during the COVID-19 pandemic and identify influencing factors of successful SC. METHODS: Healthy patients at the SC clinic aged ≥18 years before the COVID-19 pandemic and during the COVID-19 pandemic were divided into groups A and B, respectively. The two groups' demographic data and smoking characteristics were compared, and SC interventions were applied by the same medical staff team through telephone follow-up and counselling during the SC procedure. RESULTS: Groups A and B included 306 and 212 patients, respectively, with no significant differences in demographic data. The SC rates of group A (pre COVID-19) and group B (during the COVID-19 pandemic) at 3 months were 23.5% and 30.7%, respectively, after the first SC visit. Those who chose to quit immediately or within 7 days were more successful than those who did not choose a quit date (p=0.002, p=0.000). Patients who learned about the SC clinic via network resources and other methods were more likely to succeed than those who learned about the clinic from their doctor or hospital publications (p=0.064, p=0.050). CONCLUSIONS: Planning to quit smoking immediately or within 7 days of visiting the SC clinic and learning about the SC clinic via the network media or other methods improved the likelihood of successful SC. SC clinics and the harm of tobacco should be promoted via network media. During consultation, the smokers should be encouraged to quit smoking immediately and establish an SC plan, which would help them to quit smoking.
作者机构：
[Zou, Yanhui; Zhu, Lei; Qiu, Yanfang F.; Wang, Wei; Chang, Xiaochang; Zhong, Rui; Zhong, Xianmin; Yu, Xinhua; Zhang, Lemeng M.; Xie, Jianghua H.] Cent South Univ, Hunan Canc Hosp, Canc Hosp, Xiangya Sch Med, Changsha, Peoples R China.;[Zhu, Lei; Xie, Jianghua H.] Hunan Univ Chinese Med, Sch Nursing, Changsha, Peoples R China.;[Xie, Jianghua H.] Cent South Univ, Xiangya Hosp, Dept Otorhinolaryngol Head & Neck Surg, Changsha, Peoples R China.;[Hu, Yina] Wuhan Donghu Univ, Sch Nursing & Hlth Management, Wuhan, Peoples R China.;[Zhong, Rui] Cent South Univ, Hunan Canc Hosp, Canc Hosp, Xiangya Sch Med, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
关键词：
mobile medical treatment;WeChat mini program;smoking cessation evaluation
摘要：
INTRODUCTION Many smokers in China desire to quit, though the success rate among adults is low. This study evaluated the effects of QuitAction, a WeChat smoking cessation platform, summarized the intervention experience of the smoking cessation platform, identified aspects of the platform that necessitated improvement, and provided references for further optimization of the smoking cessation platform. METHODS This single-arm study was conducted in Hunan, China, from September 2020 to October 2021. Regular smokers, who were aged >= 15 years and willing to quit smoking using QuitAction, were recruited. An in-application questionnaire evaluated participants' baseline smoking status and intention to quit smoking. The QuitAction program included questionnaires regarding the participants' ongoing smoking cessation status at 24 hours, one week, one month and three months after quitting. The smoking cessation procedure was discontinued if the participant had no intention of continuing. The smoking cessation rate, influencing success factors, frequency of use satisfaction, and helpfulness of QuitAction were recorded. RESULTS A total of 303 participants registered and logged into the QuitAction program, including 59 with incomplete information and 64 with no intention of quitting. The study finally included 180 participants. The smoking cessation rate was 33.9% at 24 hours, 27.2% at one week, 26.1% at one month, and 25.0% at three months. QuitAction was reported as helpful by 94.9% of participants and 95.7% were satisfied with the program. Participants with a quitting difficulty score of 80-100 were less likely to quit smoking than participants with a difficulty score of 0-60 (OR=0.28; 95% CI: 0.10-0.78; p=0.015). Participants using the platform >= 5 times were more likely to quit smoking than those who used the platform <5 times (OR=3.59; 95% CI: 1.51-8.52; p=0.004). CONCLUSIONS The QuitAction platform provides smoking cessation services that can improve smokers' success rate and improve user experience satisfaction.
关键词：
Anxiety;Depression;Emotion dysregulation;Internet gaming disorder;Metacognitions about online gaming;Negative affect
摘要：
BACKGROUND: Recent studies have found that emotion dysregulation, negative affect, and metacognitions about online gaming are risk factors for Internet gaming disorder (IGD). However, few studies investigated the mechanisms underlying these interactions. The present study aimed to explore the relationships between emotion dysregulation and IGD, and the mediating effects of negative affect and metacognitions about online gaming. METHODS: An online survey was conducted with young people (aged 10-24years) who played video games. 1768 participants were included in this study. Observed variables, including emotion dysregulation, IGD, depression, anxiety, and metacognitions, were measured with self-report scales. Structural equation modeling (SEM) was used to analyze the relationships among the variables. RESULTS: The results showed that emotion dysregulation positively predicted IGD through a fully mediated model which included the independent mediating effects of negative affect and metacognitions about online gaming and their sequential mediating effect. The model explained 76.1% of the variance in IGD. LIMITATIONS: This was a cross-sectional study which could not infer causality. CONCLUSIONS: This study emphasizes that negative affect and metacognitions about online gaming mediate the effect of emotion dysregulation on IGD; moreover, metacognition may be a proximal factor of IGD. Thus, improving emotional regulation and modifying maladaptive metacognitions in young people may improve the prevention and treatment of IGD.
作者机构：
[Zhu, Lihui; Zhang, Na; Zhu, LH] Cent South Univ, Hunan Canc Hosp, Xiangya Sch Med, Nursing Teaching & Res Sect,Canc Hosp, Changsha, Peoples R China.;[Zhang, Na; Xu, Yi] Hunan Childrens Hosp, Dept Nursing, Changsha, Peoples R China.;[Hu, Yaojia] Hunan Childrens Hosp, Dept Ophthalmol, Changsha, Peoples R China.;[Jiang, Sishan; Zhang, Zhiqiang; Xiang, Yuqiong; Luo, Tingwei] Hunan Univ Chinese Med, Dept Nursing, Changsha, Peoples R China.;[Chen, Muhua; Xiong, Yuee] Hunan Childrens Hosp, Dept Neonatol, Changsha, Peoples R China.
通讯机构：
[Zhu, LH ] C;Cent South Univ, Hunan Canc Hosp, Xiangya Sch Med, Nursing Teaching & Res Sect,Canc Hosp, Changsha, Peoples R China.
关键词：
Pediatric healthcare workers;Children’s palliative care;Humanistic care
摘要：
Palliative care has become a key medical field worldwide. Although research relating to adult palliative care is well-established, less is known about children’s palliative care (CPC). Therefore, this study investigated the knowledge, attitude and behavior of pediatric healthcare workers (PHWs) regarding CPC and analyzed the influencing factors for the implementation and development of CPC. A cross-sectional survey of 407 PHWs was carried out in a Chinese province from November 2021 to April 2022. The questionnaire consisted of two parts: a general information form and questions on the knowledge, attitude and behavior of PHWs about CPC. Data were analyzed using t-test, ANOVA and multiple regression analysis. The total score of the PHWs’ knowledge, attitude and behavior about CPC was 69.98, which was at a moderate level. PHWs’ CPC knowledge, attitude, and behavior are positively correlated.The most important influencing factors were working years, highest education, professional title, job position, marital status, religion, grade of hospital (I, II or III), type of medical institution, experience of caring for a terminally ill child/kinsfolk and total hours of CPC education and training received. In this study, PHWs in a Chinese province had the lowest scores on the knowledge dimension of CPC, with moderate attitude and behavior and various influencing factors. In addition to professional title, highest education and working years, it is also worth noting that the type of medical institution and marital status also affected the score. Continuing education and training of PHWs in CPC should be emphasized by the administrators of relevant colleges and medical institutions. Future research should start with the above-mentioned influencing factors and focus on setting up targeted training courses and evaluating the post-training effects.
摘要：
BACKGROUND: Promoting self-directed learning (SDL) among nursing undergraduates is crucial to meet the new requirements of the healthcare system and to adapt to online learning contexts during the COVID-19 pandemic. Therefore, identifying the classification features of SDL ability and developing targeted interventions are both critical. Professional identity (PI) may contribute to the cultivation of SDL ability, but their relationship remains relatively unknown. This study aimed to explore the subgroups of SDL ability and their differences in PI among nursing undergraduates during the COVID-19 pandemic. METHODS: A total of 2438 nursing undergraduates at four universities in China were enrolled in this cross-sectional study from November 2021 to February 2022. The Self-Directed Learning Scale of Nursing Undergraduates (SLSNU) and the Professional Identity Scale for Nursing Students (PISNS) were administered. A latent profile analysis was performed to explore SDL ability latent profiles. Multinomial logistic regression analysis was conducted to examine the predictors of profile membership, and a one-way analysis of variance was applied to compare the PI scores in each latent profile. RESULTS: Three latent profiles were identified and labeled 'low SDL ability' (n = 749, 30.7%), 'low initiative of help-seeking' (n = 1325, 54.4%) and 'high SDL ability' (n = 364, 14.9%). Multinomial logistic regression analysis suggested that nursing undergraduates who voluntarily chose a nursing major, had served as a student cadre, and had participated in clinical practicum were less likely to be included in the "low SDL ability" group. The average PI score was statistically different across the three profiles (F = 884.40, p < 0.001). CONCLUSION: The SDL ability among nursing undergraduates was divided into three profiles, and results show that promoting PI may effectively foster SDL ability. This study highlights the importance of targeted interventions by considering their distinct SDL ability patterns, especially during the COVID-19 pandemic.
期刊：
Frontiers in Public Health,2023年11:1293134 ISSN：2296-2565
通讯作者：
Song, Zhenyan;Cheng, SW
作者机构：
[Song, Zhenyan; Guo, Minhua; Cheng, Shaowu; Song, ZY; He, Jiawei; Cheng, SW; Wang, Shiwei] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Peoples R China.;[Song, Zhenyan; Guo, Minhua; Cheng, Shaowu; Song, ZY; He, Jiawei; Cheng, SW; Wang, Shiwei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410128, Peoples R China.;[Wang, Weijie] Hunan Univ Chinese Med, Sch Informat, Changsha, Peoples R China.
通讯机构：
[Song, ZY; Cheng, SW ] H;Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Peoples R China.;Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410128, Peoples R China.
关键词：
Barthel Index (BI);activities of daily living;machine learning algorithm;memory-related diseases;the China health and retirement longitudinal survey
摘要：
INTRODUCTION: Memory-related diseases (MDs) pose a significant healthcare challenge globally, and early detection is essential for effective intervention. This study investigates the potential of Activities of Daily Living (ADL) as a clinical diagnostic indicator for MDs. Utilizing data from the 2018 national baseline survey of the China Health and Retirement Longitudinal Study (CHARLS), encompassing 10,062 Chinese individuals aged 45 or older, we assessed ADL using the Barthel Index (BI) and correlated it with the presence of MDs. Statistical analysis, supplemented by machine learning algorithms (Support Vector Machine, Decision Tree, and Logistic Regression), was employed to elucidate the relationship between ADL and MDs. BACKGROUND: MDs represent a significant public health concern, necessitating early detection and intervention to mitigate their impact on individuals and society. Identifying reliable clinical diagnostic signs for MDs is imperative. ADL have garnered attention as a potential marker. This study aims to rigorously analyze clinical data and validate machine learning algorithms to ascertain if ADL can serve as an indicator of MDs. METHODS: Data from the 2018 national baseline survey of the China Health and Retirement Longitudinal Study (CHARLS) were employed, encompassing responses from 10,062 Chinese individuals aged 45 or older. ADL was assessed using the BI, while the presence of MDs was determined through health report questions. Statistical analysis was executed using SPSS 25.0, and machine learning algorithms, including Support Vector Machine (SVM), Decision Tree Learning (DT), and Logistic Regression (LR), were implemented using Python 3.10.2. RESULTS: Population characteristics analysis revealed that the average BI score for individuals with MDs was 70.88, significantly lower than the average score of 87.77 in the control group. Pearson's correlation analysis demonstrated a robust negative association (r = -0.188, p < 0.001) between ADL and MDs. After adjusting for covariates such as gender, age, smoking status, drinking status, hypertension, diabetes, and dyslipidemia, the negative relationship between ADL and MDs remained statistically significant (B = -0.002, β = -0.142, t = -14.393, 95% CI = -0.002, -0.001, p = 0.000). The application of machine learning models further confirmed the predictive accuracy of ADL for MDs, with area under the curve (AUC) values as follows: SVM-AUC = 0.69, DT-AUC = 0.715, LR-AUC = 0.7. Comparative analysis of machine learning outcomes with and without the BI underscored the BI's role in enhancing predictive abilities, with the DT model demonstrating superior performance. CONCLUSION: This study establishes a robust negative correlation between ADL and MDs through comprehensive statistical analysis and machine learning algorithms. The results validate ADL as a promising diagnostic indicator for MDs, with enhanced predictive accuracy when coupled with the Barthel Index. Lower levels of ADL are associated with an increased likelihood of developing memory-related diseases, underscoring the clinical relevance of ADL assessment in early disease detection.
摘要：
BackgroundThe incidence of depression has been increasing globally, which has brought a serious burden to society. Sinisan Formula (SNSF), a well-known formula of traditional Chinese medicine (TCM), has been found to demonstrate an antidepressant effect. However, the therapeutic mechanism of this formula remains unclear. Thus, the present study aimed to explore the mechanism of SNSF in depression through network pharmacology combined with molecular docking methods. Materials and methodsBioactive compounds, potential targets of SNSF, and related genes of depression were obtained from public databases. Essential ingredients, potential targets, and signaling pathways were identified using bioinformatics analysis, including protein-protein interaction (PPI), the Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, Autodock software was further performed for conducting molecular docking to verify the binding ability of active ingredients to targets. ResultsA total of 91 active compounds were successfully identified in SNSF with the use of the comprehensive network pharmacology approach, and they were found to be closely connected to 112 depression-related targets, among which CREB1, NOS3, CASP3, TP53, ESR1, and SLC6A4 might be the main potential targets for the treatment of depression. GO analysis revealed 801 biological processes, 123 molecular functions, and 67 cellular components. KEGG pathway enrichment analysis indicated that neuroactive ligand-receptor interaction, serotonergic synapse pathways, dopaminergic synapse pathways, and GABAergic synapse pathways might have played a role in treating depression. Molecular docking suggested that beta-sitosterol, nobiletin, and 7-methoxy-2-methyl isoflavone bound well to the main potential targets. ConclusionThis study comprehensively illuminated the active ingredients, potential targets, primary pharmacological effects, and relevant mechanism of the SNSF in the treatment of depression. SNSF might exert its antidepressant effects by regulating the signaling pathway of 5-hydroxytryptamine, dopamine, GABA, and neuroactive ligand receptor interactions. Still, more pharmacological experiments are needed for verification.
期刊：
Frontiers in Psychology,2022年13:953491 ISSN：1664-1078
作者机构：
[Zhang, Jingping; Yin, Yizhen] Cent South Univ, Xiang Ya Nursing Sch, Changsha, Hunan, Peoples R China.;[Lyu, Mengmeng] Natl Univ Singapore, Alice Lee Ctr Nursing Studies, Yong Loo Lin Sch Med, Singapore, Singapore.;[Chen, Yiping; Xia, Guili] Southern Med Univ, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China.;[Zhang, Jie] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.;[Li, Hui] Sichuan Univ, West China Hosp, Dept Orthoped, Chengdu, Sichuan, Peoples R China.
摘要：
BackgroundThe prognosis of patients undergoing lung cancer treatment might be influenced by mental health status. Resilience is one of the important predictors to reflect the mental health status. It has been shown that patients with higher levels of social support, self-care self-efficacy, and positive coping have greater resilience. This study aimed to determine the mediating role of self-efficacy and positive coping in the relationship between social support and psychological resilience in patients with lung cancer. MethodThis is a cross-sectional study that was conducted in in the oncology departments and thoracic surgical wards of four tertiary hospitals in Hunan Province, China, between November 2016 and November 2017. Three hundred and three patients who were undergoing treatment for lung cancer volunteered their participation in the study. Participants completed questionnaires, including the Chinese version of the Perceived Social Support Seale Scale, the Chinese version of Strategies Used by People to Promote Health Scale, and the Chinese version of the Connor-Davidson Resilience Scale. ResultsMediation analysis indicated that self-care self-efficacy and social support partially mediate the effect of social support on resilience. Direct paths from social support to self-efficacy, self-efficacy to positive coping, positive coping to psychological resilience, self-efficacy to psychological resilience, and social support to psychological resilience were significant (p < 0.001). The indirect paths from social support to self-efficacy and self-efficacy to psychological resilience were also significant. The chain mediation from social support to self-efficacy, self-efficacy to positive coping, and positive coping to resilience were significant. ConclusionSelf-efficacy and positive coping play an important role in the relationship between social support and resilience in patients receiving cancer treatment. Social support not only directly influenced psychological resilience but also indirectly influenced psychological resilience through self-efficacy and positive coping.
期刊：
Frontiers in Psychology,2022年13:2611 ISSN：1664-1078
通讯作者：
Lee, M.
作者机构：
[Tang, PeiXi] Hunan Univ Chinese Med, Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Coll Clin Med,Dept Sleeping, Changsha, Peoples R China.;[Lee, MaoSheng] Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Clin Med Coll 4, Dept Endocrinol,Dept Sleeping Disorders & Neurosis, Shenzhen, Peoples R China.
通讯机构：
Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China
