摘要：
The ability to appropriately recognize the facial expression of emotions is essential for the development of adaptive functioning. Studies suggest that maltreated children are hypersensitive to expression of anger. However, the neural mechanism of emotional face processing in young adults with a history of childhood maltreatment has yet to be explored. To explore whether the history of childhood maltreatment has a potential relationship with processing of emotional facial expressions, the present study used event-related potentials in investigating the early ERP components (P100 and N170) to the processing of emotional (angry, fearful, disgusted, and happy) faces in young adult victims of childhood maltreatment. Seventeen young adults with a history of childhood maltreatment and seventeen age and gender-matched non-maltreated participants performed a modified dot-probe task, using emotional faces paired with neutral faces. Results revealed no significant differences between maltreated group and non-maltreated group in P100 amplitude, but the N170 amplitude in the maltreated group was larger than non-maltreated group when processing angry, fearful, and happy faces. As such, this study provides biological evidence of altered neural processing of emotional facial expressions in young adults with a history of childhood maltreatment.
作者机构：
[Fu Xiaogao; Gong Jingbo] Hunan Univ Chinese Med, Dept Appl Psychol, Changsha 410208, Hunan, Peoples R China.;[Chan, Raymond C. K.; Wang Ya] Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China.;[Liu Jianbo] Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.;[Cheung, Eric F. C.] Castle Peak Hosp, Hong Kong, Peoples R China.;[Chan, Raymond C. K.] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
通讯机构：
[Chan, Raymond C. K.] I;Inst Psychol, Room 526,South Block,16 Lincui Rd, Beijing 100101, Peoples R China.
摘要：
This study aimed to measure the associations between high sensitivity C-reactive protein (hsCRP), childhood maltreatment (CM), schizotypy and response inhibition, and to explore the interactions between hsCRP, CM and schizotypy on response inhibition. Two hundred and fourteen participants completed the Stop-Signal Task (SST), the Schizotypy Personality Questionnaire (SPQ) and the Childhood Trauma Questionnaire-Short Form (CTQ), which measured response inhibition, schizotypy and history of CM respectively. The level of hsCRP was also measured. The high schizotypy group (n = 114) had higher scores on SPQ and CTQ, higher hsCRP levels and longer SST reaction times (SSRTs) than the low schizotypy group (n = 100). In female participants, SSRT had a positive correlation with the SPQ positive factor and the disorganized SPQ factor and a positive correlation with physical neglect. HsCRP was positively correlated with the SPQ negative factor and positive SPQ factor. In male participants, SSRT was negatively correlated with emotional neglect and physical neglect. The majority of correlations between CTQ and SPQ variables were significant in both female and male participants. In female participants, hsCRP significantly predicted SSRT, and hsCRP significantly interacted with positive schizotypy in predicting SSRT.
作者机构：
[Ren, Yujia] Hunan First Normal Univ, Phys Educ Inst, Third Fenglin Rd, Changsha 410205, Hunan, Peoples R China.;[Ji, Binbin] Hunan Univ Chinese Med, Sch Nursing, Changsha 410205, Hunan, Peoples R China.
通讯机构：
[Ren, Yujia] H;Hunan First Normal Univ, Phys Educ Inst, Third Fenglin Rd, Changsha 410205, Hunan, Peoples R China.
关键词：
loneliness, perceived social support;psychological capital;adolescents
摘要：
BACKGROUND: Adolescence is a period characterized by high frequency of mental health problems. Loneliness, in particular, is a common psychological problem. This study aims to explore the effects of psychological capital on adolescents' loneliness and the mediating effects of perceived social support. SUBJECTS AND METHODS: A total of 694 adolescents from six regions in Hunan Province, China were selected. The survey was conducted using the Perceived Social Support Scale, Loneliness Scale, and Psychological Capital Questionnaire. The study analyzed the correlations between perceived social support, psychological capital, and loneliness among adolescents and the mediating role of psychological capital in the relationship between perceived social support and loneliness. RESULTS: Significant correlations were observed between adolescents' total scores in perceived social support, psychological capital, and loneliness and between each dimension. The following observations were made: a significant negative correlation between perceived social support and loneliness (r=0.440, P<0.01), a significant positive correlation between perceived social support and psychological capital (r=0.493, P<0.01), and a significant negative correlation between psychological capital and loneliness (r=-0.303, P<0.01). Psychological capital plays a statistically significant mediating role on the relationship between perceived social support and loneliness (P<0.01). CONCLUSIONS: Perceived social support and psychological capital can reduce adolescents' loneliness and perceived social support can alleviate loneliness by enhancing psychological capital.
摘要：
The main clinical manifestations of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis are acute or subacute seizures, cognition impairment, and psychiatric symptoms. Nowadays, the scheme of antipsychotic therapy for this disease has not been established. This study reports three cases of anti-NMDAR encephalitis with psychiatric symptoms. The anti-NMDAR antibodies in cerebrospinal fluid (CSF) and serum were positive. The psychiatric symptoms still existed after intravenous immunoglobulin (IVIG) treatment; thus, clozapine was used for antipsychotic therapy. Case 1 was a 37-year-old man who suffered from bad mood and suicide behaviors for 1 month. Hallucination and delusion still existed after IVIG treatment and hormone therapy, and the symptoms were relieved when given clozapine for 12 months. Case 2 was a 28-year-old man who was admitted to our hospital due to injuring other people and destructive behaviors for 2 days. He showed irritability, bad temper, declined cognition, and severe delusion of persecution after IVIG treatment and hormone therapy, but the psychiatric symptoms disappeared when given clozapine for 3 months. Case 3 was a 23-year-old man who suffered from headache and babbing for 7 days. Symptoms such as irritability, bad temper, babbing, and injuring other people still existed after IVIG treatment and hormone therapy, but they disappeared when given clozapine for 2 months. Therefore, we suggest that during the treatment of anti-NMDAR encephalitis with psychiatric symptoms, if the anti-NMDAR antibodies in CSF and serum were positive, and psychiatric symptoms could not be controlled after IVIG and hormone therapy, clozapine may work.
关键词：
"polycystic ovary syndrome";"second-hand smoke";"sex hormones";"metabolic syndrome";"pregnancy and obstetric outcomes"
摘要：
Does second-hand smoke (SHS) exposure from husbands have adverse effects on sex hormones, metabolic profiles, clinical phenotypes and fertility outcomes in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction?
通讯机构：
[Zhang, Bin] H;Hunan Univ Chinese Med, Dept Appl Psychol, Xiang Zui Rd 39, Changsha 410208, Hunan, Peoples R China.
关键词：
college students;cross-cultural;Dispositional Hope Scale;measurement equivalence
摘要：
The original Snyder's Dispositional Hope Scale (DHS) was applied to 224 American college students and the Chinese version to 255 Chinese college students. Equivalence of the two DHS was tested, including configural invariance, metric invariance, and scalar invariance. The results demonstrated that the Snyder's DHS has measurement equivalence between Chinese and American college students; that is, the same psychological structure was measured in Chinese and American college samples. Therefore, cross-cultural measurements of hope are valid. In addition, Chinese college students and American college students did not differ significantly on the Agency factor of the DHS whereas American students scored significantly higher than did Chinese college students on the Pathways factor. This dissimilarity may be explained by differences in the cultural backgrounds and education systems of the two countries.
通讯机构：
[Zhang, Xi] H;Hunan Univ Chinese Med, Dept Pathol, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
关键词：
Qianlongtong;BPH;apoptosis
摘要：
Qianlongtong is a compound made from traditional Chinese herbs and it has proven to be very effective to treat patients with benign prostate hypertrophy. However, its mechanism is still unknown. This study is designed to investigate the effect of Qianlongtong on proliferation and apoptosis of hyperplastic prostate cells. Flow cytometry (FCM) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) were used to assess proliferation and apoptosis of hyperplastic prostate cells in the following groups: control group, tamoxifen group, and groups with low, moderate, and high dosage of Qianlongtong. Reverse transcription-polymerase chain reaction analysis was used to investigate the underlying mechanisms for increased apoptosis. Cells treated with Qianlongtong were mainly blocked in the G0/G1 phase. The apoptotic index of each group was significantly higher than that in the control group. The apoptotic index in the high- and moderate-dosage groups was similar to that in the tamoxifen group. The high- and moderate-dosage groups had lower Bcl-2 and higher Bax messenger RNA (mRNA) levels compared with the control group. Qianlongtong inhibits proliferation and promotes the apoptosis of hyperplastic prostate cells.
关键词：
Online social networksFluid dynamicsInfluence maximizationAttitudeDiffusion model
摘要：
In online social networks, many application problems can be generalized as influence
maximization problem, which targets at finding the top-k influential users. Most of the existing
influence spread models ignore user's attitude and interaction and cannot model the …
摘要：
The aim of the current study was to examine whether early maladaptive schemas (EMSs) mediate the association between different kinds of childhood maltreatment and later psychopathology and the effect of different kinds of childhood maltreatment on psychological distress in later life. A total of 1102 college students from two local universities participated in the study; their average age was 20.46 +/- 1.13 years. The participants completed the Childhood Trauma Questionnaire (CTQ), the Early Maladaptive Schemas Scale (EMSs), the Zung Self-Rating Depression Scale (SDS), and the Zung Self-Rating Anxiety Scale (SAS). Later psychological distress had a significant positive correlation with childhood EMSs, and almost all of the variables measuring childhood maltreatment had a significant positive correlation with EMSs. Structural equation modeling and mediation analyses were conducted based on Bootstrap estimations; the mediation analyses demonstrated the utility of EMSs as the mechanism through which childhood maltreatment has an indirect effect on later psychological distress. Moreover, the study found that emotional abuse had the strongest overall effect of all five types of child maltreatment on later psychological distress, followed in order of magnitude by emotional neglect, physical neglect, sexual abuse, and physical abuse.
期刊：
Evidence-Based Complementary and Alternative Medicine,2018年2018:2901863 ISSN：1741-427X
通讯作者：
Wang, Yuhong
作者机构：
[Li, Wei; Liu, Jian; Yang, Hui] Hunan Univ Chinese Med, Affiliated Hosp 1, Pharmacol Res Ctr, Changsha, Hunan, Peoples R China.;[Yang, Hui] Hunan Univ Chinese Med, Domest First Class Construct Discipline Chinese M, Changsha, Hunan, Peoples R China.;[Meng, Pan; Wang, Yuhong; Liu, Zhuo] Hunan Univ Chinese Med, Key Lab Chinese Mat Med Power & Innovat Drugs Est, Changsha, Hunan, Peoples R China.;[Wang, Yuhong] Hunan Univ Chinese Med, Inst Innovat & Appl Res, Changsha, Hunan, Peoples R China.
通讯机构：
[Wang, Yuhong] H;Hunan Univ Chinese Med, Key Lab Chinese Mat Med Power & Innovat Drugs Est, Changsha, Hunan, Peoples R China.;Hunan Univ Chinese Med, Inst Innovat & Appl Res, Changsha, Hunan, Peoples R China.
摘要：
Diabetes-induced brain insulin resistance is associated with many mental diseases, including depression. Epidemiological evidences demonstrate the pathophysiologic link between stress, depression, and diabetes. This study was designed to determine whether chronic unpredictable mild stress- (CUMS-) induced changes in brain insulin resistance could contribute to deterioration in mood and cognitive functions in diabetic rats. Male SD rats were randomly assigned to three groups, including standard control group, the diabetes group, and the diabetes with CUMS group. After 7 weeks, emotional behaviors and memory performances as well as metabolic phenotypes were measured. In addition, we examined the changes in protein expression related to brain insulin signaling. Our results show that rats in diabetes with CUMS group displayed a decreased locomotor behavior in open-field test, an increased immobility time in forced swim test, and tail suspension test, and an impaired learning and memory in the Morris water maze when compared to animals in diabetes group. Further, diabetes with CUMS exhibited a significant decrease in phosphorylation of insulin receptor and an increase phosphorylation of IRS-1 in brain. These results suggest that the depression-like behaviors and cognitive function impairments in diabetic rats with CUMS were related to the changes of brain insulin signaling.
