通讯机构：
[Peng, Qinghua] H;Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.
摘要：
Background. Qing Guang An Granule (QGAG), a Chinese patent medicine, has been used clinically to treat glaucoma for more than 20 years. Objective. To explore the possible mechanism of treatment of QGAG in glaucoma by using network pharmacology and molecular docking in this study. Methods. Active compounds and targets of each herb in QGAG were retrieved via the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Glaucoma-related targets were acquired from OMIM and DisGeNET database. Key targets of QGAG against glaucoma were acquired by overlapping the above targets via the Venn diagram. Using the DAVID, Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the key targets were performed. The docking process was performed using the AutoDock 4.2.6 and AutoDock Vina 1.1.2. Results. The 55 active compounds and 173 targets were obtained and constructed a compound-target network. The 20 key targets of QGAG in treating glaucoma were acquired, and these targets are involved in the apoptotic process, cellular response to hypoxia, negative regulation of cell growth, and ovarian follicle development. The main pathways are p53, HIF-1, PI3K-Akt, and neurotrophin signaling pathway. Conclusion. QGAG may exert a protective effect by acting on the optic nerve at a molecular and systemic level. This study can provide a certain basis for future researches on exploring the QGAG in treating glaucoma and provide new ideas for developing new drugs.
通讯机构：
[Liu Zu-Guo] F;[Peng Qing-Hua] H;Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China<&wdkj&>Xiamen Eye Center of Xiamen University, Xiamen, Fujian 361001, China<&wdkj&>Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China<&wdkj&>Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Changsha, Hunan 410208, China<&wdkj&>Department of Ophthalmology, the First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China
作者机构：
[欧晨; 蒋鹏飞; 姚震; 田野; 王英] Hunan University of Chinese Medicine, Changsha, Hunan Province 410208, China;Department of Ophthalmology, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province 410007, China;Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases in Hunan Province, Changsha, Hunan Province 410208, China;[彭俊] Department of Ophthalmology, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province 410007, China, Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases in Hunan Province, Changsha, Hunan Province 410208, China;[彭清华] Hunan University of Chinese Medicine, Changsha, Hunan Province 410208, China, Department of Ophthalmology, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province 410007, China, Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases in Hunan Province, Changsha, Hunan Province 410208, China
通讯机构：
[Peng, Q.-H.] H;Hunan University of Chinese MedicineChina
摘要：
摘要：
新型冠状病毒肺炎属于中医学“疫病”范畴，中医眼科学将疫病引起的眼病称为“天行赤眼”，对轻症治疗以疏风清热为主，对重症治疗以泻火解毒为主。目前仍然不能排除结膜传播新型冠状病毒的可能性，因此眼科工作者在临床一线的诊疗中需要加强警惕。本文探讨了眼科医务工作者在眼科检查、眼科操作、眼科手术等方面预防新型冠状病毒的措施与普通人群家中预防眼病的措施。希望能对预防新型冠状病毒有所帮助。
Abstract:
Coronavirus disease 2019 (COVID-19) belongs to the category of "epidemic disease" in traditional Chinese medicine. Traditional Chinese medicine ophthalmology name the eye disease caused by the epidemic disease as "acute contagious conjunctivitis", and the treatment for mild patients mainly on dispersing wind and clearing heat, while the severe ones are purging fire and removing toxin. At present, the possibility of conjunctival transmission of novel coronavirus (2019-nCoV) still don't rule out. Therefore, ophthalmologists need to be more vigilant in the first-line clinical diagnosis and treatment. This article not only discusses how ophthalmologists can prevent 2019-nCoV in ophthalmological examination, ophthalmic operations, and ophthalmic surgery, but also the general population in home. Hope have a notable curative effect in prevent 2019-nCoV.
