作者：
Mandi, Fakhri;Morgan, J. Brian;Liu, Wenlong;Agarwal, Ameeta K.;Jekabsons, Mika B.;...
期刊：
Journal of Natural Products,2015年78(12):3018-3023 ISSN：0163-3864
通讯作者：
Zhou, Yu-Dong
作者机构：
[Mandi, Fakhri; Zhou, Yu-Dong; Morgan, J. Brian; Liu, Yang; Liu, Wenlong; Nagle, Dale G.] Univ Mississippi, Dept Biomol Sci, University, MS 38677 USA.;[Agarwal, Ameeta K.] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA.;[Agarwal, Ameeta K.; Nagle, Dale G.] Univ Mississippi, Res Inst Pharmaceut Sci, Sch Pharm, University, MS 38677 USA.;[Jekabsons, Mika B.] Univ Mississippi, Dept Biol, University, MS 38677 USA.;[Zhou, Yu-Dong] Univ Mississippi, Dept Chem & Biochem, University, MS 38677 USA.
通讯机构：
[Zhou, Yu-Dong] U;Univ Mississippi, Dept Biomol Sci, University, MS 38677 USA.
摘要：
The cananga tree alkaloid sampangine (1) has been extensively investigated for its antimicrobial and antitumor potential. Mechanistic studies have linked its biological activities to the reduction of cellular oxygen, the induction of reactive oxygen species (ROS), and alterations in heme biosynthesis. Based on the yeast gene deletion library screening results that indicated mitochondrial gene deletions enhanced the sensitivity to 1, the effects of 1 on cellular respiration were examined. Sampangine increased oxygen consumption rates in both yeast and human tumor cells. Mechanistic investigation indicated that 1 may have a modest uncoupling effect, but predominately acts by increasing oxygen consumption independent of mitochondrial complex IV. Sampangine thus appears to undergo redox cycling that may involve respiratory chain-dependent reduction to a semi-iminoquinone followed by oxidation and consequent superoxide production. Relatively high concentrations of 1 showed significant neurotoxicity in studies conducted with rat cerebellar granule neurons, indicating that sampangine use may be associated with potential neurotoxicity.
作者机构：
[唐宇; 刘志刚; 刘文龙; 廖琼; 杨岩涛; 胡超] Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha, 410208, China;Key Laboratory of Property and Pharmacodynamics, State Administration of Chinese Medicine, Changsha, 410208, China;Pharmaceutical Preparation Technology and Evaluation Laboratory of Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;Supramolecular Mechanism and Mathematics-Physics Characterization Laboratory for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;[邓凯文] The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China
通讯机构：
[Deng, K.-W.] T;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China
作者机构：
[Liu, Wenlong; Zhang, Ping; Chen, Zuohong] Hunan Normal Univ, Sch Life & Sci, Changsha 410081, Hunan, Peoples R China.;[Li, Rongdong; Zhang, Xili; He, Fuyuan; Liu, Wenlong] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.;[Huang, Sheng] Hunan Jiuzhitang Co Ltd, Changsha 410007, Hunan, Peoples R China.
通讯机构：
[Chen, Zuohong] H;Hunan Normal Univ, Sch Life & Sci, Changsha 410081, Hunan, Peoples R China.
关键词：
Chinese medicine;Dissolution;Release kinetics;ZJSRT
摘要：
ZuoJin sustained-release tablets (ZJSRT), which consist of Rhizoma coptidis-Evodia rutaecarpa powder (6:1, g/g), have been widely used for a long time as a treatment of gastrointestinal disorders in China. Because ZJSRT is a kind of Chinese medicine prescription (CMP), it comprises many components, which makes the quality control studies more difficult. The main aim of this paper was to evaluate the release of four alkaloids using kinetic models and to assess the dissolution behaviors of ZJSRT using total quantum statistical moment (TQSM). The release data generated during in vitro release studies were fitted to zero-order, first-order, Higuchi, Hill, Weibull, and Michaelis-Menten models. The dissolution behavior data were obtained by calculating the TQSM parameters. The release kinetics of ZJSRT from most formulations follow a classical Fickian diffusion mechanism but do not follow an empirical model. The data from the TQSM parameters demonstrate that all components in ZJSRT released at nearly the same ratio and the same time. Therefore, the study should contribute to the quality control for CMP such as ZJSRT.
作者机构：
[石继连; 田静; 王海琴] College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Province 12-5 Provincial Key Disciplines of Pharmacy, Changsha 410208, China;[吴春英] College of Management and Information Engineering, Hunan University of Chinese Medicine, Changsha 410208, China;[杨岩涛; 刘文龙; 贺福元] College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China, Hunan Province 12-5 Provincial Key Disciplines of Pharmacy, Changsha 410208, China
通讯机构：
[He, F.-Y.] C;College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
作者机构：
[胡超; 唐宇; 廖琼; 邹欢] Department of Pharmaceutics, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China;Property and Pharmacodynamic Key Laboratory of Chinese Materia Medica, State Administration of Chinese Medicine, Changsha, 410208, China;Pharmaceutical Preparation Technology and Evaluation Laboratory of Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;[贺福元] Department of Pharmaceutics, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Property and Pharmacodynamic Key Laboratory of Chinese Materia Medica, State Administration of Chinese Medicine, Changsha, 410208, China, Pharmaceutical Preparation Technology and Evaluation Laboratory of Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China, Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[He, F.-Y.] D;Department of Pharmaceutics, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China
作者机构：
[唐宇; 吴德智] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China;Key Laboratory of Property and Pharmacodaynamics for TCM, State Administration of Traditional Chinese Medicine, Changsha, 410208, China;Pharmaceutical Preparation Technology and Evaluation Laboratory of TCM, Hunan University of Tradition Chinese Medicine, Changsha, 410208, China;[吴春英] College of Management and Information Engineering, Hunan University of Traditional Chinese Medicine, Changsha, 410208, China;Supermolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Traditional Chinese Medicine, Changsha, 410208, China
通讯机构：
[He, F.-Y.] C;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China
作者机构：
[刘珊; 张喜利; 赵先平; 刘文龙; 刘平安; 贺福元] Key Laboratory for Traditional Chinese Medicine Modernization, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China;[陈爱军] Hunan Polytechnic College of Environment and Biology, Hengyang, 421005, China;[张云莉] Hunan Schistosomiasis Control Station in Beihekou Anxiang, Changde, 415600, China
通讯机构：
[Liu, W.-L.] K;Key Laboratory for Traditional Chinese Medicine Modernization, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China
