作者机构：
College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, 410208, China;Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China;[邓凯文] The First Affinity Hospital, Hunan University of Chinese Medicine, Changsha, 410007, China;[贺鹏; 李海英; 樊启猛; 贺玉婷] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, 410208, China
通讯机构：
[He, F.-Y.] C;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China
作者机构：
[唐昱; 李海英; 陈思阳] Department of Pharmaceutic, Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China;[刘平安] Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan, Changsha, 410208, China;Department of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medicine, Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China;[邓凯文] The First Affiliated Hospital of Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China;[刘润南; 贺福元; 刘文龙; 樊启猛; 贺鹏] Department of Pharmaceutic, Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China, Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan, Changsha, 410208, China, Department of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medicine, Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China
通讯机构：
[HE, F.-Y.] D;Department of Pharmaceutic, Hunan, China
摘要：
Background: It is well-known that the public still have been facing on a severe issue about the inconsistency of quality and therapeutic efficacy of traditional medicines. Recently, Professor Chang-Xiao Liu has created a new promising concept for identifying relevant quality-markers (Q-marker) from herbs, their formulas and manufacturing products. Therefore, building up a new approach is necessary for us to bridge over quality to efficacy of pharmaceutical products. Study design: In this paper, five candidate Q-markers, astragaloside IV, paeonflorin, amygdalin, tetra-methylpyrazine, ferulic acid in Buyanghuanwu injection (BYHWI) had been designed to carry out in rat by using single and polypharmacokinetic models for total quanta to ascertain adequate Q-marker. Methods: The Q-marker transitivity in vivo was studied with polypharmacokinetic model and its similarity approach, which were modeled with TQSM principle. The Q-marker was ascertained with transitive similarity and bioavailability in polypharmacokinetics. Their concentrations in plasma sample of white rat were determined by RP-HPLC. Data analyses were used by the DAS software for singles and myself-written-program with EXCEL for multiples. Results: In BYHWI, five candidate Q-marker pharmacokinetic profiles were singly fixed to two compartmental models in rat using classical compartmental analysis, but there were tremendous differences among which the candidate parameters were fluctuated from nearly 3552 folds to equivalency. The theoretical value of TQSM polypharmacokinetic parameters such as AUC(T), MRTT, VRTT, CLT, V-T over the mixure of five drugs were 110.8 +/- 51.91 mg min ml(-1), 176.0 +/- 36.5 min, 39,921 +/- 4311 min(2), 0.3116 +/- 0.02347 ml min(-1) kg(-1), 54.83 +/- 7.683 ml kg(-1) respectively. The TQSM polypharmacokinetic parameters in astragaloside IV ordered by AUC(T), MRTT, VRTT, CLT, V-T were 110.8 +/- 51.91 mg min ml(-1), 176.0 +/- 36.5 min, 39,921 +/- 4311 min(2), 0.3116 +/- 0.02347 ml min(-1) kg(-1), 54.83 +/- 7.683 ml kg(-1), respectively, which were closed to the theoretical values. TQSM similarity versus astragaloside IV was 0.9661. Conclusion: The results represented that the optimum Q-marker in BYHWI is astragaloside IV, whose transitivity in vivo similarity was close to the behavior of polypharmacokinetics with maximum bioavailability to the total quanta. It is feasible for Q-marker in CMMs to screen on the comparison of single pharmacokinetic behavior and bioavailability to the total quanta.
作者机构：
湖南中医药大学药学院, 湖南, 长沙, 410208;中药成药性与制剂制备湖南省重点实验室, 中药成药性与制剂制备湖南省重点实验室, 湖南, 长沙, 410208;湖南中医药大学中医药超分子机理与数理特征化实验室, 湖南, 长沙, 410208;[刘惠; 王韧; 李文姣; 樊启猛; 陈思阳] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, Hunan 410208, China;[肖美凤; 贺福元; 刘文龙; 杨岩涛; 周逸群] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, Hunan 410208, China, Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
通讯机构：
[He, F.-Y.] C;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China
作者机构：
湖南中医药大学药学院,湖南长沙410208;中药成药性与制剂制备湖南省重点实验室,湖南长沙410208;湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208;湖南中医药大学第一附属医院,湖南长沙410007;[贺福元; 刘惠; 肖美凤; 周晋; 刘文龙; 杨岩涛] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, Hunan 410208, China, Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
通讯机构：
[Deng, K.-W.] S;Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, Hunan, China
作者机构：
湖南中医药大学药学院,湖南长沙410208;中药成药性与制剂制备湖南省重点实验室,湖南长沙410208;湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208;[李文姣; 贺福元; 周晋; 刘惠; 唐闻汉; 王韧; 刘文龙] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, 410208, China, Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构：
[Zhou, J.] C;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China
