作者机构：
湖南中医药大学药学院,湖南长沙410208;中药成药性与制剂制备湖南省重点实验室,湖南长沙410208;常德市第一中医医院,湖南常德415000;湖南中医药大学中西医结合学院,湖南长沙410208;[刘文龙] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Changsha, 410208, China, Changde First Hospital of Traditional Chinese Medicine, Changde, 415000, China
通讯机构：
[Zhang, X.-L.; Ge, J.-W.] C;College of Integrated Traditional Chinese and Western Medicine, China;College of Pharmacy, China
摘要：
Objective:To observe the applied values of external application of Xinshang Shifu(新伤湿敷,XSSF)solution to preoperative treatment of tibial plateau fractures.Methods:Sixty patients who would receive surgery for tibial plateau fractures were selected and randomly divided into conventional therapy group and external application group,30 cases in each group.All patients were treatd with dehydration and detumescence therapy using mannitol and anticoagulant therapy using low-molecular-weight heparins calcium(LMWHC),and were instructed to perform quadriceps femoris isometric contraction and ankle functional exercises before the surgery;moreover,the patients in external application group were treatd with external application of XSSF solution at the fractured parts,twice a day,till the limb swelling was eliminated.The affected limb swelling rate,visual analogue scale(VAS)scores and operating-room waiting time were recorded and compared between the 2 groups.Results:One patient in external application group and 2 patients in conventional therapy group dropped out of the study.There was interaction between time factor and group factor in affected limb swelling rate(F=35.234,P=0.000).There was statistical difference in affected limb swelling rate between the 2 groups in general,in other words,there was group effect(F=-1.986,P=0.012).There was statistical difference in affected limb swelling rate between different timepoints before and after the treatment,in other words,there was time effect(F=619.710,P=0.000).The affected limb swelling rate presented a time-dependent trend of increasing firstly and decreasing subsequently in the 2 groups,while the 2 groups were inconsistent with each other in the variation tendency(7.83+/-1.52,9.73+/-1.90,10.84+/-2.00,5.63+/-1.23%,F=387.336,P=0.000;7.67+/-1.65,9.49+/-1.70,10.79+/-1.66,6.68+/-1.63%,F=459.514,P=0.000).There was no statistical difference in affected limb swelling rate between the 2 groups before treatment and after 1-and 3-day treatment(t=0.381,P=0.705;t=0.497,P=0.621;t=0.
摘要：
中药注射剂(traditional chinese medicine injections,TCMIs)临床疗效确切,但其类过敏反应频发,日益增多的不良反应事件已成为当前中药安全性研究的热点和难点.类过敏反应的发生机制尚未完全明确,其常规评价标准及风险防控措施还存在一定局限性,亟需建立一套能广泛筛查TCMIs类致敏原、明确类致敏发生机制的TCMIs安全性评价方法.本文对近年来有关TCMIs类过敏反应的机制、物质基础以及评价方法的研究进行综述,旨在深入挖掘TCMIs类过敏反应的综合信息,以期为建立TCMIs类过敏反应评价与风险防控新方法、减少TCMIs临床不良反应的发生提供新的思路.
作者机构：
[肖美凤] College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Hunan Provincial Key Laboratory of Drugability and Preparation Modification of Traditional Chinese Medicine Changsha 410208, China;[段晓鹏] College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine Changsha 410208, China;[邓凯文] The First Affinity Hospital, Hunan University of Chinese Medicine Changsha 410007, China;[刘文龙; 贺福元; 杨岩涛] College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Hunan Provincial Key Laboratory of Drugability and Preparation Modification of Traditional Chinese Medicine Changsha 410208, China Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine Changsha 410208, China
通讯机构：
The First Affinity Hospital, Hunan University of Chinese Medicine, Changsha, China
