作者： Nie, Duorui;Yang, Jing;Zheng, Hao;Lai, Guihua;Wang, Fei;...

期刊： BMC Gastroenterology,2023年23(1):1-10 ISSN：1471-230X

通讯作者： Gong, C

作者机构： [Nie, Duorui; Wang, Fei; Gong, Chun; Lai, Guihua; Gong, C] Hunan Univ Chinese Med, Hosp 1, Dept Oncol, Changsha, Peoples R China.;[Zheng, Hao; Yang, Jing] Guangzhou Univ Chinese Med, Clin Med Coll 1, Guangzhou, Peoples R China.;[Cao, Jianxiong] Hunan Univ Chinese Med, Sch Continuing Educ, Changsha, Peoples R China.

通讯机构： [Gong, C ] H;Hunan Univ Chinese Med, Hosp 1, Dept Oncol, Changsha, Peoples R China.

关键词： Nomogram;Pancreatic signet ring cell carcinoma;Prognosis;Survival;SEER

摘要： This study aimed to compare the incidence, clinicopathological characteristics and survival results of pancreatic signet ring cell carcinoma (PSRCC) and pancreatic adenocarcinomas (PDAC), as well as to analyze the clinical characteristics related to the overall survival (OS) of PSRCC, and to establish an effective prognostic nomogram to predict the risks associated with patient outcomes. A total of 85,288 eligible patients including 425 PSRCC and 84,863 PDAC cases were retrieved from the Surveillance, Epidemiology, and End Results database. The survival curve was calculated using the Kaplan–Meier method and differences in them were measured by Log-rank tests. The Cox proportional hazards regression model was used to identify independent predictors of OS in patients with PSRCC. A nomogram was constructed to predict 1-, 3-, and 5-year OS. The performance of the nomogram was measured by C-index, receiver operating characteristic (ROC) curve, decision curve analysis (DCA). The incidence of PSRCC is much lower than that of PDAC (10.798 V.S. 0.349 per millions). PSRCC is an independent predictor of pancreatic cancer with a poorer histological grade, a higher rate of lymph node and distant metastasis, and a poorer prognosis. We identified four independent prognostic factors including grade, American Joint Committee on Cancer Tumor-Node-Metastasis (TNM) stage, surgery and chemotherapy based on the Cox regression model. The C-index and DCA curves showed better performance of the nomogram than TNM stage. ROC curve analysis also showed that the nomogram had good discrimination, with an area under the curve of 0.840, 0.896, and 0.923 for 1-, 3-, and 5-year survival. The calibration curves showed good agreement between the prediction by the nomogram and actual observations. PSRCC is a rare but fatal subtype of pancreatic cancer. The constructed nomogram in this study accurately predicted the prognosis of PSRCC, performed better than the TNM stage.

语种： 英文

作者： Lai, Gui-Hua;Wang, Fei;Nie, Duo-Rui;Lei, Shu-Jun;Wu, Zhuo-Jun;...

期刊： Evidence-Based Complementary and Alternative Medicine,2022年2022:1-13 ISSN：1741-427X

通讯作者： Cao, JX

作者机构： [Lai, Gui-Hua; Lei, Shu-Jun; Wang, Fei; Nie, Duo-Rui; Wu, Zhuo-Jun] Hunan Univ Chinese Med, Grad Sch, Changsha 410208, Hunan, Peoples R China.;[Cao, Jian-Xiong] Hunan Univ Chinese Med, Sch Continuing Educ, Changsha 410208, Hunan, Peoples R China.

通讯机构： [Cao, JX ] H;Hunan Univ Chinese Med, Sch Continuing Educ, Changsha 410208, Hunan, Peoples R China.

摘要： Background. Houttuynia cordata Thunb. is a traditional Chinese herb widely used mainly because of the pharmacological effects related to heat clearance and detoxification. Emerging clinical evidence indicates that the efficacy of Houttuynia cordata Thunb. on RILI is upstanding. Nevertheless, its underlying therapeutic mechanism remains unclear and warrants further elucidation. Methods. The major active components and corresponding targets of Houttuynia cordata Thunb. were retrieved from the traditional Chinese medicine system pharmacology database (TCMSP) and literature review. The related targets of RILI were retrieved from the GeneCards database. Common targets among the active compounds and diseases were identified through Venn diagram analysis. Cytoscape was employed to construct and visualize the network relationship among the drug, active compounds, targets, and disease. The protein interaction network (PPI) was constructed by STRING. The reliability (the binding affinity) of the core targets and active compounds was verified by molecular docking. Results. A search of the TCMSP database and related literature revealed 12 active compounds of Houttuynia cordata Thunb. against RILI. The core active compounds included quercetin, kaempferol, hyperoside, and rutin. Hub nodes including TP53, VEGFA, JUN, TNF, and IL-6 were identified in the PPI network. The GO categories were classified into three functional categories: 112 biological processes, 9 molecular functions, and 32 cellular components of the active compounds of Houttuynia cordata Thunb. The KEGG pathway enrichment analysis demonstrated the enrichment of target genes in several key cancer-related signaling pathways, including the cancer pathways, TNF signaling pathway, PI3K-Akt signaling pathway, and HIF-1 signaling pathway. Molecular docking analysis validated the effective binding capacity of the main active compounds with the core targets. Conclusion. The main active components of Houttuynia cordata Thunb. have a potential pharmacological effect against RILI via the cancer pathways, TNF signaling pathway, and PI3K-Akt signaling pathway. © 2022 Gui-Hua Lai et al.

语种： 英文

作者： Lai, Gui-hua;Wang, Fei;Nie, Duo-rui;Lei, Shu-jun;Wu, Zhuo-jun;...

期刊： Evidence-Based Complementary and Alternative Medicine,2022年2022:2192654 ISSN：1741-427X

通讯作者： Cao, JX

作者机构： [Lei, Shu-jun; Wang, Fei; Lai, Gui-hua; Nie, Duo-rui; Wu, Zhuo-jun] Hunan Univ Chinese Med, Grad Sch, Changsha 410208, Hunan, Peoples R China.;[Lei, Shu-jun; Wang, Fei; Lai, Gui-hua; Nie, Duo-rui; Wu, Zhuo-jun] Hunan Univ Chinese Med, Hosp 1, Changsha 410021, Hunan, Peoples R China.;[Cao, Jian-xiong] Hunan Univ Chinese Med, Sch Continuing Educ, Changsha 410208, Hunan, Peoples R China.;[Tang, Lan-lan] Ningxiang Hosp Chinese Med, Ningxiang 410399, Hunan, Peoples R China.

通讯机构： [Cao, JX ] H;Hunan Univ Chinese Med, Sch Continuing Educ, Changsha 410208, Hunan, Peoples R China.

关键词： Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles

摘要： Cancer is a complex disease with several distinct characteristics, referred to as "cancer markers"one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer. In cancer, the oxidative phosphorylation metabolic pathway is converted into the glycolytic pathway in order to meet the growth requirements of cancer cells, thereby creating a microenvironment that promotes cancer progression. The precise mechanism of glucose metabolism in cancer cells is still unknown, but it is thought to involve the aberrant levels of metabolic enzymes, the influence of the tumor microenvironment (TME), and the activation of tumor-promoting signaling pathways. It is suggested that glucose metabolism is strongly linked to cancer progression because it provides energy to cancer cells and interferes with antitumor drug pharmacodynamics. Therefore, it is critical to unravel the mechanism of glucose metabolism in tumors in order to gain a better understanding of tumorigenesis and to lay the groundwork for future research into the identification of novel diagnostic markers and therapeutic targets for cancer treatment. Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, multiple components, and less toxic side effects and has unique advantages in tumor treatment. In recent years, researchers have found that a variety of Chinese medicine monomers and compound recipes play an antitumor role by interfering with the reprogramming of tumor metabolism. The underlying mechanisms of metabolism reprogramming of tumor cells and the role of TCM in regulating glucose metabolism are reviewed in this study, so as to provide a new idea for antitumor research in Chinese medicine. © 2022 Gui-hua Lai et al.

语种： 英文

作者： Nie, Duorui;Lai, Guihua;An, Guilin;Wu, Zhuojun;Lei, Shujun;...

期刊： FRONTIERS IN ONCOLOGY,2021年11:719253 ISSN：2234-943X

通讯作者： Li, J;Cao, JX

作者机构： [Nie, Duorui; Wu, Zhuojun; Lei, Shujun; Lai, Guihua] Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.;[An, Guilin] Ningxia Med Univ, Sch Tradit Chinese Med, Yinchuan, Ningxia, Peoples R China.;[Li, Jing; Lei, Shujun] Hunan Univ Chinese Med, Dept Oncol, Hosp 1, Changsha, Peoples R China.;[Cao, Jianxiong; Cao, JX] Hunan Univ Chinese Med, Sch Continuing Educ, Changsha, Peoples R China.

通讯机构： [Li, J ; Cao, JX ] H;Hunan Univ Chinese Med, Dept Oncol, Hosp 1, Changsha, Peoples R China.;Hunan Univ Chinese Med, Sch Continuing Educ, Changsha, Peoples R China.

关键词： Metastatic pancreatic cancer;Surgery;chemotherapy;prognosis analysis.;nomogram

摘要： <jats:sec><jats:title>Background</jats:title><jats:p>Metastatic pancreatic cancer (mPC) is a highly lethal malignancy with poorer survival. However, chemotherapy alone was unable to maintain long‐term survival. This study aimed to evaluate the individualized survival benefits of pancreatectomy plus chemotherapy (PCT) for mPC.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A total of 4546 patients with mPC from 2004 to 2015 were retrieved from the Surveillance, Epidemiology, and End Results database. The survival curve was calculated using the Kaplan-Meier method and differences in survival curves were tested using log-rank tests. Cox proportional hazards regression analyses were performed to evaluate the prognostic value of involved variables. A new nomogram was constructed to predict overall survival based on independent prognosis factors. The performance of the nomogram was measured by concordance index, calibration plot, and area under the receiver operating characteristic curve.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Compared to pancreatectomy or chemotherapy alone, PCT can significantly improve the prognosis of patients with mPC. In addition, patients with well/moderately differentiated tumors, age ≤66 years, tumor size ≤42 mm, or female patients were more likely to benefit from PCT. Multivariate analysis showed that age at diagnosis, sex, marital status, grade, tumor size, and treatment were independent prognostic factors. The established nomogram has a good ability to distinguish and calibrating.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>PCT can prolong survival in some patients with mPC. Our nomogram can individualize predict OS of pancreatectomy combined with chemotherapy in patients with concurrent mPC.</jats:p></jats:sec>

语种： 英文

作者： 李雪晶;胡凯

期刊： 科教文汇(下旬刊),2016年(21):9-11 ISSN：1672-7894

作者机构： 湖南中医药大学继续教育学院 湖南·长沙 410007;中南大学马克思主义学院 湖南·长沙 410083;[胡凯] 中南大学;[李雪晶] 湖南中医药大学

关键词： 马克思主义人学;大学生;成功观

摘要： 成功是人类特有的需要,人追求成功是人的生理需要、社会需要和精神需要的统一表现,成功是人自然属性、社会属性和精神属性的辩证统一。青年的价值取向决定了未来整个社会的价值取向,本文运用马克思主义人学对大学生成功观进行探析,指出了"人的自然属性明确大学生成功需要的合理性"、"人的社会属性决定大学生成功社会价值的必要性"、"人的精神属性鼓励大学生成功追求的目的性"。运用马克思主义人学对成功观进行探析,有利于正确认识成功观,有利于大学生将个人理想与社会理想紧密结合起来,凝聚全民族的力量,为实现"中国梦"而奋斗。

语种： 中文

作者： 李雪晶;胡凯

期刊： 科教文汇(下旬刊),2016年(7):168-171 ISSN：1672-7894

作者机构： 湖南中医药大学继续教育学院 湖南·长沙 410007;中南大学马克思主义学院 湖南·长沙 410083;[胡凯] 中南大学;[李雪晶] 湖南中医药大学

关键词： 中国;美国;成功观;比较;启示

摘要： 本文探讨了美国和中国的成功观的基本内容和各自的历史渊源。美国成功观的特点是财富至上,以个人为中心;中国成功观的特点是权力至上,以集体为中心。通过对中美传统成功观的比较我们认为,道德品质是成功的坚实基石,勤奋务实是成功的必要途径,积极乐观是成功的应有心态。

语种： 中文

作者： 王健

期刊： 读写算：小学高年级,2011年(23):41-41,28 ISSN：1002-7661

作者机构： 湖南中医药大学成人教育学院;[王健] 湖南中医药大学

关键词： 以人为本;高校学生;管理;管理科学

摘要： 随着经济的发展与社会的进步，以人为本的管理理念越来越深入人心。以人为本，是科学发展观的核心，是中国共产党坚持全心全意为人民服务的根本宗旨的体现。以人为本在高校学生管理中发挥着重要作用，它顺应了新时期高等教育的规律和趋势，是发展高等教育的内在需求，也是高校培养新世纪优秀人才的必然要求：本文从以人为本的内涵出发，分析以人为本的管理理念的本质属性及如何实现有效的以人为本的高校学生管理。

语种： 中文

作者： 王健

期刊： 时代教育(小学版),2011年(6):52 ISSN：1672-8181

作者机构： 湖南中医药大学成人教育学院,湖南,长沙,410007;[王健] 湖南中医药大学

关键词： 高校学生管理;管理水平;人才培养

摘要： 高校的管理水平高低直接关系到大学生的成长与成才,如何加强高校学生管理,为培养高质量的大学生服务,已经成为高校学生管理者新的研究任务。从客观意义上讲,要着力提高高校的学生管理水平,必须从以下几个方面着手解决：了解高校学生的思想动态,对高校学生管理模式不断创新,对高校学生管理任务要有新的理解。

语种： 中文

作者： 王健

期刊： 教育界：高等教育研究,2011年(10):40

作者机构： 湖南中医药大学成人教育学院;[王健] 湖南中医药大学

关键词： 高校学生;自我管理;管理工作

摘要： 随着高等教育的普及，高校学生的成才关系到整个国民教育水平的高低。然而，高校学生的管理也渐渐成为社会上炙手可热的话题。笔者认为对于高校学生的管理，应该坚持学生自我管理为主，高校的监督为辅。这不仅是高校学生全面发展的内在需求，也是实现高等教育总体目标的外在需要。本文着重介绍了高校学生自我管理的重要性及如何实现自我管理，提出了高校学生自我管理的新理念。

语种： 中文

作者： 卓晖

期刊： 卫生职业教育,2009年27(21):33-34 ISSN：1671-1246

作者机构： 湖南中医药大学成教学院,湖南,长沙,410007;[卓晖] 湖南中医药大学

关键词： 成教学生;党员发展;入党率

摘要： 与全日制大学生相比,成教学生在思想水平、知识结构、社会经历等方面具有自身特点.党员发展工作面临成教学生入党积极性不高问题的原因有:思想觉悟较低,对党的认识模糊,入党氛围较差.应针对成教学生的特点及存在的问题,采取多种措施,提高成教学生入党率.

语种： 中文

作者： 卓晖

期刊： 中医药导报,2007年13(12):103+105 ISSN：1672-951X

作者机构： 湖南中医药大学成教学院 湖南长沙410007;[卓晖] 湖南中医药大学

关键词： 思想政治;与时俱进

摘要： 分析新时期高校学生思想政治教育工作的形势,提出要与时俱进,增添思想政治工作内容;完善机制,增强思想政治工作的活力;创新方法,实现政治工作由传统向现代的转变.

语种： 中文

作者： 卓晖

期刊： 长沙铁道学院学报(社会科学版),2007年8(2):247+256

作者机构： 湖南中医药大学成教学院 湖南长沙410007;[卓晖] 湖南中医药大学

关键词： 高校学生干部;干部工作;能力素质;历史唯物主义;学生工作;毛泽东思想;辨证唯物主义;教育方针;主要表现;高校工作

摘要： 高校学生干部是高校思想政治教育、业务教学和行政管理工作的得力助手,高校学生干部工作是高校这些工作得以实现所必须又不可替代的重要环节,同时,又是为党的事业培养和锻炼骨干力量的重要途径.

语种： 中文

作者： 卓晖

期刊： 中医药导报,2007年13(10):109-110 ISSN：1672-951X

作者机构： 湖南中医药大学成人教育学院 湖南长沙410007;[卓晖] 湖南中医药大学

关键词： 成人教育;问题;对策

摘要： 文章深入分析了当前成人高等教育中教师教学的问题、课程的问题等,提出了解决问题的对策和建议,认为要进一步改变观念,顺应时代,创新机制,以适应新形势下成人高等教育的发展..

语种： 中文

作者： 文志;徐绍勤;周光源;李凡成;彭斌

期刊： 中国中西医结合耳鼻咽喉科杂志,2004年12(4):176-178 ISSN：1007-4856

作者机构： 湖南中医学院附属第二医院;湖南中医学院成教学院;湖南中医学院附属第二医院 长沙410005;[文志; 周光源; 徐绍勤; 彭斌] 湖南中医学院第二附属医院;[李凡成] 湖南中医学院

关键词： 鼻敏片;豚鼠;变应性鼻炎;鼻黏膜形态学;副作用

摘要： 目的观察鼻敏片对豚鼠变应性鼻炎鼻黏膜形态学的影响,证实其治疗作用.方法以TDI为致敏原,对豚鼠行鼻内给药法建立鼻超敏反应模型.造模成功后随机分为治疗组和对照组,分别予鼻敏片和息斯敏进行处理,观察比较两组鼻黏膜形态学.结果鼻敏片能抑制炎症细胞的聚集,促进鼻黏膜修复,对AR有明显治疗作用.结论鼻敏片能有效治疗变应性鼻炎,且较息斯敏有疗效持久、无副作用等优点.

语种： 中文

作者： 文志;徐绍勤;周光源;李凡成;彭斌

期刊： 中药新药与临床药理,2004年15(5):312-314 ISSN：1003-9783

作者机构： 湖南中医学院附属二医院耳鼻喉科;湖南中医学院成教学院;湖南中医学院附属二医院耳鼻喉科 长沙410005;长沙410007;[文志; 周光源; 徐绍勤; 彭斌] 湖南中医学院第二附属医院

关键词： 鼻敏片;变应性鼻炎;鼻粘膜形态学

摘要： 目的观察鼻敏片对豚鼠变应性鼻炎鼻黏膜形态学的影响,探讨其治疗机制.方法以甲苯 2, 4-二异氰酸酯为致敏原,对豚鼠行鼻内给药法建立鼻超敏反应模型,以息斯敏为对照药,对鼻粘膜形态学进行观察.结果 鼻敏片能减轻鼻部流涕、喷嚏等症状,抑制炎症细胞的聚集,促进鼻黏膜修复,药效较息斯敏持久.结论鼻敏片能有效治疗变应性鼻炎.

语种： 中文

作者： 易法银;胡方林（胡方林）

期刊： 上海中医药杂志,2003年37(2):42-44 ISSN：1007-1334

作者机构： 湖南中医学院成人教育学院,湖南,长沙,410007;[胡方林; 易法银] 湖南中医学院

关键词： 王旭高;肝病;肝气;肝风;肝火;病因;脉象;治疗

摘要： 清代名家王旭高为疗肝病之大家,其肝病证治特点为:以肝气、肝风、肝火立论,注重脉证,强调外感六淫、内伤情志及痰饮瘀血均可致肝病,疏畅条达以治肝气,柔体济刚以熄肝风,补虚泻实以治肝火.

语种： 中文

作者： 易法银;吴爱华

期刊： 湖南中医药大学学报,2003年23(3):27-27,33 ISSN：1674-070X

作者机构： 湖南中医学院成教学院;[易法银; 吴爱华] 湖南中医学院

关键词： 甲状腺机能亢进症;病因病机(中医);治标;治本

摘要： 甲状腺机能亢进症(简称甲亢)与中医瘿病,虽两者关系密切,但不能完全划等号.历代医家把瘿病责之于肝,强调气滞、痰浊、瘀血等邪实因素为主要病机;现代医家多认为甲亢的病机是以阴虚为本,以火郁、痰凝、血瘀为标,表现为本虚标实、虚实夹杂的证候.故甲亢的治疗应始终坚持标本兼顾的原则,具体治法以养阴、降火、化痰、活血为主.

语种： 中文

作者： 李高平

期刊： 湖南医科大学学报(社会科学版),2002年(S1):41-43 ISSN：1008-8229

作者机构： 湖南中医学院成人教育学院 湖南长沙410007;[李高平] 湖南中医学院

关键词： 终身教育体系;成人高等教育;终生学习;时代脉搏;《中华人民共和国教育法》;学习化社会;教育市场;终身学习;成人教育;成人高校

摘要： 进入 2 1世纪 ,在高等教育蓬勃发展的大好形势下 ,全国普通高校连续三年扩招 ,形势喜人 ,而成人高等教育却面临了严峻的招生形势.虽然成人高校招生计划也在逐年扩大 ,基本上缓解了长期以来成人高考入学难的紧张局面 ,但带来的负面影响却是成人高考的计划生源比逐年缩小 ,生源质量逐年下降(其中最明显...>>详细

语种： 中文

作者： 刘卫英;邓元江

期刊： 中医药导报,2002年8(4):210-210,214 ISSN：1672-951X

作者机构： 湖南中医学院成人教育学院,湖南,长沙,410007;[刘卫英; 邓元江] 湖南中医学院

关键词： 成人教育;中医学专业;课程体系

摘要： 当前成人教育脱产本科中医学专业课程体系存在着一定弊端,应根据时代要求改进课程体系,培养符合当今世界医学模式转变、以初级保健为基础的高素质的应用型临床医师.

语种： 中文

作者： 李春湘;彭清华（彭清华）

期刊： 辽宁中医药大学学报,2001年3(3):174-177 ISSN：1673-842X

作者机构： 湖南中医学院成人教育学院;[彭清华] 湖南中医学院第一附属医院;[李春湘] 湖南中医学院

关键词： 原发性闭角型青光眼;A型行为;人格特征;调查报告

摘要： 运用"A型行为问卷"和"艾森克(成人)人格问卷表"(Eysenck Personality Questionaire,EPQ)对138例原发性闭角型青光眼患者和51例正常人分别进行了A型行为和人格特征的调查分析,结果:急、慢性闭角型青光眼患者A型性格所占比例和A型行为得分中TH、CH、TH+CH得分值均明显高于正常人,有显著性意义(P《0.05或《0.01);闭角型青光眼患者EPQ人格结构中N、L值亦显著升高,有显著性意义(P《0.05或《0.01).说明A型行为和心理负担较重的人格特征是原发性闭角型青光眼的发病基础.

语种： 中文