期刊：
Complementary Therapies in Medicine,2022年67:102831 ISSN：0965-2299
作者机构：
[Zhao, Jie] Hunan Univ Chinese Med, Grad Sch, Changsha 410208, Hunan, Peoples R China.;[Ai, Jun] Guangxi Univ Chinese Med, Basic Med Sch, Nanning 530200, Guangxi, Peoples R China.;[Shi, Wei; Meng, LiFeng; Mo, Chao] Guangxi Univ Chinese Med, Affiliated Hosp 1, Dept Nephrol, 327 Xian Hu Rd, Nanning 530023, Guangxi, Peoples R China.;[Mo, Chao] Guangxi Univ Chinese Med, Grad Sch, Nanning 530200, Guangxi, Peoples R China.;[Meng, LiFeng] Southwest Med Univ, Tradit Chinese & Western Med Lab Controlling Orga, Luzhou 646000, Sichuan, Peoples R China.
摘要：
BACKGROUND: Bailing Capsule (BLC), Jinshuibao (JSB), Huangkui Capsule (HKC), Uremic Clearance Granule (UCG), Tripterygium glycosides (TG), Compound Xueshuantong Capsule (CXC), and Shenyan Kangfu Tablet (SYKFT) as classic Chinese patent medicines (CPMs), have been widely used and shown beneficial effects on the treatment of early diabetic kidney disease (DKD). However, the comparative efficacy of seven CPMs in the treatment of early DKD remains unknown. OBJECTIVE: To evaluate and compare the efficacy of seven CPMs (BLC, JSB, HKC, UCG, TG, CXC, SYKFT) combined with angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) on early DKD by a Bayesian network meta-analysis (NMA) of randomized controlled trials (RCTs). METHODS: A comprehensive and systematic literature search was performed in PubMed, Embase, Cochrane Library, Web of Science, Clinical Trials.gov, China Biology Medicine, Chinese National Knowledge Infrastructure, Chinese Scientific Journal, and Wanfang databases from inception to March 14, 2021, for full-text RCTs that evaluated the efficacy of seven CPMs combined with ACEI/ARB on patients with early DKD. Two reviewers independently screened studies for eligibility, extracted data, and assessed the risk of bias. Agreement between reviewers was measured using kappa statistics. Mean difference (MD) and odds ratio (OR) were calculated to evaluate continuous variables and dichotomous, respectively. The random effect modeling NMA was performed and the ranking probability of interventions in various outcomes was also conducted based on the surface under the cumulative ranking curve (SUCRA). Begg's and Egger's tests were used to evaluate publication bias. The certainty of the evidence for outcomes was evaluated according to the GRADE system. RESULTS: A total of 62 RCTs with 5362 patients with early DKD were identified. The value of Kappa calculated for the various parameters extracted by the two investigators was 0.821 (P<0.001). Among these CPMs, UCG+ACEI/ARB showed the best effectiveness for urinary albumin excretion rate (UAER) (MD 32.25, 95% CrI 19.11-45.67, low certainty) with SUCRA 92%. JSB+ACEI/ARB showed the highest effectiveness for 24-h urinary total protein (24-h UTP) (MD 76.92, 95% CrI 53.54-100.58, low certainty) with SUCRA 97%. CXC+ACEI/ARB showed the highest effectiveness for serum creatinine (SCr) (MD 26.02, 95% CrI 6.10-45.95, low certainty) with SUCRA 96%. HKC+ACEI/ARB showed the highest effectiveness for blood urea nitrogen (BUN) (MD 1.46, 95% CrI 0.42-2.54, very low certainty) with SUCRA 86%. BLC+ACEI/ARB showed significant differences in triglyceride (TRIG) (MD -1.17, 95% CrI -1.93 to -0.43, low certainty) with SUCRA 90%, total cholesterol (TC) (MD -1.17, 95% CrI -1.97 to -0.39, very low certainty) with SUCRA 90%, and C-reaction protein (CRP) (MD -0.90, 95% CrI -1.51 to -0.32, very low certainty) with SUCRA 76%. CONCLUSIONS: CPMs+ACEI/ARB might be positive efficacious interventions from which patients with DKD will derive benefit. UCG+ACEI/ARB, JSB+ACEI/ARB, CXC+ACEI/ARB, and HKC+ACEI/ARB might be potentially the preferred intervention for reducing UAER, 24-h UTP, SCr, and BUN levels, respectively. BLC+ACEI/ARB has a better impact on lowing TRIG, TC, and CRP levels in patients with early DKD. However, more high-quality, large-scale, multi-center RCTs and stronger head-to-head trials are required to confirm these findings.
期刊：
Frontiers in Pharmacology,2022年13:2067 ISSN：1663-9812
通讯作者：
Fu, W.
作者机构：
[You, Xujun] Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.;[Li, Qixin; You, Xujun; Fu, Wei] Guangzhou Univ Chinese Med, Shenzhen Baoan Tradit Chinese Med Hosp, Dept Androl, Shenzhen, Peoples R China.;[Wu, Yongrong] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Peoples R China.;[Sheng, Wen] Hunan Univ Chinese Med, Androl Lab, Changsha, Peoples R China.;[Zhou, Qing] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Androl, Changsha, Peoples R China.
通讯机构：
Department of Andrology, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China
关键词：
Astragalus-Scorpio;prostate cancer;PI3K;AKT;Astragaloside IV;polypeptide extract from scorpion venom;autophagy
作者机构：
[来奕恬; 周竞颖; 丁攀婷] Graduate School of Hunan University of Chinese Medicine, Changsha 410208, China;[刘密; 李南; 张国山] College of Acupuncture-moxibustion-Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208;[邱冉冉] The First Hospital of Hunan University of Chinese Medicine, Changsha 410007
摘要：
Objective:To analyze the medication rules of TCM medicine in the treatment of the Qi and Yin deficiency type(气阴两虚型)Sjögren's syndrome.Methods:The prescriptions for treating Sjögren’s syndrome in CNKI were retrieved,and a relevant database was established.“Traditional Chinese Medicine Inheritance Support System 3.0”platform was used for an analysis.Results:124 prescriptions were screened out,with 223 Chinese medicinal materials,19 of which appeared more than 25 times.The medicinal property was mainly mild cold,with sweet flavor,and its active ingredients were mainly absorbed by lung meridian.The most commonly used Chinese medicinal materials were tonifying Qi(气)medicine,nourishing Yin(阴)medicine,clearing heat medicine,and promoting blood circulation medicine.30 high-frequency medicine pairs,26 medicine combinations,and 13 new prescriptions were obtained from further study.Conclusion:This study analyzes the medication rules of Chinese medicinal materials in the treatment of the Qi and Yin deficiency type Sjögren’s syndrome,and provide useful reference for clinical prevention and treatment of Sjögren’s syndrome in TCM.
摘要：
The etiology and pathogenesis of granulomatous lobular mastitis (GLM) remain largely elusive and the expression levels and regulatory roles of microRNAs (miRNAs or miRs) in GLM have remained mostly undetermined. In the present study, the miRNAs that were differentially expressed in breast biopsy samples from patients with GLM and normal tissue adjacent to fibroadenoma were analyzed, a comprehensive differential expression profile of miRNAs was provided and potential biomarkers were screened out. The expression profile of miRNAs was determined by high-throughput sequencing in the tissues of patients with GLM and healthy controls. Significantly differentially expressed miRNAs were screened by threshold setting and cluster analysis and their target genes were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. Finally, circulating differentially expressed miRNAs between the GLM and control groups were further analyzed by reverse transcription-quantitative PCR (RT-qPCR). A total of 31,077 miRNAs were detected by high-throughput sequencing. By using the cutoff criteria of |log2 fold change|>2.5 and q<0.001, 13 miRNAs that were indicated to be GLM biomarkers were screened out. The expression levels of these 13 miRNAs in the GLM group were higher than those in the control group. GO and KEGG enrichment analyses suggested that the occurrence and development of GLM may be associated with autoimmune inflammation, metabolism and pathogenic organisms. miR-451a and miR-5571-3p were confirmed to be significantly increased in the serum of patients with GLM compared with their levels in the serum of healthy volunteers, which suggests that they may be used as biomarkers of GLM. To the best of our knowledge, the present study was the first report detailing genome-wide miRNA profiling of patients with GLM compared with controls. The possible targets and pathways of GLM were evaluated by bioinformatics analysis. The present study identified 13 differentially expressed miRNAs with important theoretical significance and potential application. Furthermore, miR-451a and miR-5571-3p were verified by RT-qPCR as possible biomarkers of GLM.
