作者机构：
[Zeng, Liuting; Yang, Kailin; Ge, Jinwen] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.
通讯机构：
[Ge, Jinwen] H;Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.
摘要：
To uncover the pharmacological mechanism of Astragalus Salvia compound (ASC) on pregnancy-induced hypertension syndrome (PIH), to provide useful information for clinical, as well as to connect the basic and clinical by a network pharmacological approach, we used network pharmacological approach. We collected ASC’s compounds by traditional Chinese Medicine databases, and input them into PharmMapper to got their targets. Then we acquired PIH targets from Genecards and OMIM, collected the interactions of all the targets and other human proteins via String and INACT. We also constructed the network by Cytoscape and analyze it by MCODE so as to get clusters. Finally, we put all the targets of clusters into DAVID to do GO enrichment analysis. After these, four networks are constructed by Cytoscape; they are PIH network, compound-compound target network of ASC, ASC-PIH network, and compound target-PIH target-other human proteins’ PPI network. According to the results, we think that ASC may directly regulate several biological processes and their genes in “endothelial cell activation and injury” and “placental or trophoblast cell ischemia” models to treat PIH. And it may indirectly act on the rest of the biological process to treat PIH or may not.
作者机构：
[Shao-wu Cheng; Huai-gang Qu; Xiao-dan Liu; Zhen-yan Song; Ping Li; Hong-wen He; Jin-wen Ge] College of integrated Traditional Chinese Medicine and Western Medicine,Hunan University of Chinese Medicine,Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases;[Shao-wu Cheng; Huai-gang Qu; Xiao-dan Liu; Zhen-yan Song; Ping Li; Hong-wen He; Jin-wen Ge] Department of Anatomy,Zhongshan School of Medicine,Sun Yat-sen University;[Shao-wu Cheng; Huai-gang Qu; Xiao-dan Liu; Zhen-yan Song; Ping Li; Hong-wen He; Jin-wen Ge] Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology
会议名称：
第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议
会议时间：
2015-09-20
会议地点：
中国浙江桐乡
摘要：
Danggui-Shaoyao-San(DSS),a traditional Chinese medicinal prescription,could alleviate cognitive dysfunction of Alzheimer’s disease(AD) patients.However,the detail mechanisms remain elusive.In the pres
作者：
Jun Liao;Qing-Ping Yu;Juan Huang;Yang Liu;Shao-Wu Cheng;...
作者机构：
[Jun Liao; Qing-Ping Yu; Juan Huang; Yang Liu; Shao-Wu Cheng; Jin-Wen Ge] Department of Anatomy,College of Integrated Traditional Chinese and Western Medicine,Hunan University of Traditional Chinese Medicine;[Jun Liao; Qing-Ping Yu; Juan Huang; Yang Liu; Shao-Wu Cheng; Jin-Wen Ge] Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases,College of Integrated Traditional Chinese and Western Medicine,Hunan University of Traditional Chinese Medicine
会议名称：
2016年国际生理学学术大会
会议时间：
2016-09-25
会议地点：
中国北京
摘要：
BACKGROUND: Iron is an important micronutrient for neuronal function and survival.It plays an essential role in synthesis of the myelin sheath and neurotransmission.On the contrary,iron also catalyses
