作者机构：
[Chi Zhang; Mi Liu] School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, China;[Jian Zhang; Cheng-xi Wang] Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China;[Ran-ran Qiu; Jiang Pan] The First Hospital of Hunan University of Chinese Medicine, Changsha, China;[Guo-shan Zhang] School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China
通讯机构：
[Cheng-xi Wang] H;[Mi Liu] S;Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China<&wdkj&>School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, China
摘要：
Objective: To observe the effect of moxibustion at Feishu (BL 13) on related inflammatory cells and inflammatory factors in the bronchoalveolar lavage fluid of asthma model rats, and to explore the mechanism of moxibustion in treating asthma. Methods: A total of 48 Sprague-Dawley (SD) rats were randomly divided into a normal group, a model group, a moxibustion group and a medication group, with 12 rats in each group. Except for the normal group, the rats in the other three groups were subjected to ovalbumin sensitization to stimulate the asthma. At the same time, rats in the moxibustion group received moxibustion at bilateral Feishu (BL 13), and rats in the medication group received dexamethasone by intragastric administration. Rats in the normal and the model groups only received the same fixation and normal saline by intragastric administration. After the interventions, the inspiratory resistance, the expiratory resistance, and the pulmonary compliance were measured for rats in each group; the numbers of the inflammatory cells in the bronchoalveolar lavage fluid were counted; the levels of the involved inflammatory factors in bronchoalveolar lavage fluid were detected; the pathological morphologies of the lung tissues were observed under light microscope. Results: After modeling, compared with the normal group, the rats in the model group showed obvious asthma attack-like response, significantly increased inspiratory resistance and expiratory resistance (both P<0.01), and significantly reduced pulmonary compliance (P<0.01); thickened tracheal wall and the narrowed tracheal lumen observed under the light microscope; infiltration of inflammatory cells and increased eosinophils in and around the tracheal wall; significantly increased total number of inflammatory cells and proportion of eosinophils in the bronchoalveolar lavage fluid (all P<0.01); significantly reduced levels of interleukin (IL)-10, IL-12 and interferon (IFN)-γ (all P<0.01), and significantly increased levels of IL-4, IL-5 and tumor necrosis factor (TNF)-α (all P<0.01) in the bronchoalveolar lavage fluid. After intervention, compared with the model group, rats in the moxibustion and the medication groups showed significantly reduced asthma-like reaction, pathological morphological damage of lung tissue, inspiratory resistance and expiratory resistance (all P<0.01); significantly increased pulmonary compliance (P<0.01); significantly reduced total number of inflammatory cells, proportion of eosinophils, levels of IL-4, IL-5 and TNF-α in the bronchoalveolar lavage fluid (P<0.05 or P<0.01), while significantly increased IL-12 and IFN-γ levels (all P<0.01) in the bronchoalveolar lavage fluid; rats in the medication group also showed a significantly reduced IL-10 level in the bronchoalveolar lavage fluid (P<0.01); there was no statistically significant difference between the moxibustion and the medication groups (all P>0.05). Conclusion: Both moxibustion at Feishu (BL 13) and intragastric administration of dexamethasone can improve the asthma attack-like symptoms of ovalbumin-sensitized rats; regulating the inflammatory cell numbers and the inflammatory factor contents in the lung may be one mechanism of moxibustion in treating asthma.
作者机构：
[张国山; 张驰] College of Acupuncture-moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha 410208, China;[张国山] Department of Pulmonary Disease, Hengyang Hospital of Chinese Medicine, Hengyang 421001, Hunan Province;[邱冉冉; 潘江] The First Hospital, Hunan University of Chinese Medicine, Changsha 410007;[张建; 王诚喜] Department of Pulmonary Disease, Hengyang Hospital of Chinese Medicine, Hengyang 421001, Hunan Province;[阳仁达] Graduate School, Hunan University of Chinese Medicine, Changsha 410208
作者机构：
[Chi Zhang] College of Acupuncture & Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha, China;[Jian Zhang; Cheng-xi Wang] Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China;[Ran-ran Qiu; Jiang Pan] The First Hospital of Hunan University of Chinese Medicine, Changsha, China;[Guo-shan Zhang] College of Acupuncture & Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China
通讯机构：
[Cheng-xi Wang] H;Hengyang Hospital of Traditional Chinese Medicine, Hengyang, China
摘要：
Objective: To analyze and summarize the commonalities and patterns in acupoint selection for moxibustion treatment of asthma. Methods: Data retrieval was conducted using ‘moxibustion’ and ‘asthma’ as the keywords through China National Knowledge Infrastructure (CNKI), Wanfang Academic Journal Full-text Database (Wanfang) and Chongqing VIP Database (CQVIP). Excel 2010 was used to establish the major acupoint database for moxibustion prescriptions in treatment of asthma; data mining methods including association patterns and clustering were adopted to analyze the characteristics and patterns in acupoint selection for moxibustion treatment of asthma. Results: A total of 161 moxibustion prescriptions were recruited. The most commonly used acupoint was Feishu (BL 13), the most commonly used meridian was the Bladder Meridian of Foot Taiyang, and the most commonly treated region was the back. The association rule analysis showed that Feishu (BL 13)-Dazhui (GV 14)-Fengmen (BL 12) had the most significant correlation, and the clustering analysis discovered 5 effective acupoint clusters. Conclusion: In moxibustion treatment of asthma, topical acupoints Feishu (BL 13), Dazhui (GV 14) and Fengmen (BL 12) can be selected, along with the acupoints from the Bladder Meridian of Foot Taiyang and the back.
摘要：
Electroacupuncture and moxibustion are traditional Chinese medicine practices that exert therapeutic effects through stimulation of specific meridian acupoints. However, the biological basis of the therapies has been difficult to establish; thus the current practices still rely on ancient TCM references. Here, we used a rat model to study perturbations in cortex, liver, and stomach metabolome and plasma hormones following electroacupuncture or moxibustion treatment on either stomach meridian or gallbladder meridian acupoints. All treatment groups, regardless of meridian and mode of treatment, showed perturbation in cortex metabolome and increased phenylalanine, tyrosine, and branched-chain amino acids in liver. In addition, electroacupuncture was found to increase ATP in cortex, creatine, and dimethylglycine in stomach and GABA in liver. On the other hand, moxibustion increased plasma enkephalin concentration, as well as betaine and fumarate concentrations in stomach. Furthermore, we had observed meridian-specific changes including increased N-acetyl-aspartate in liver and 3-hydroxybutyrate in stomach for gallbladder meridian stimulation and increased noradrenaline concentration in blood plasma following stimulation on stomach meridian. In summary, the current findings may provide insight into the metabolic basis of electroacupuncture and moxibustion, which may contribute towards new application of acupoint stimulation.
作者机构：
[Qiong LIU; De-jun WANG; Jun-yun GE; Guo-shan ZHANG; Zhou YANG; Xiao-rong CHANG] College of Acupuncture & Moxibustion and Tuina, Hunan University of CM, Changsha 410007, Hunan;[Zong-bao YANG] Guoyitang, Medical College of Xiamen University, Changsha 410007, Hunan
摘要：
Objective To explore the clinical efficacy of tuina combined with moxibustion for treatment of lung-wei insecurity-type sweating syndrome in children. Methods Infantile tuina combined with moxibustion was conducted for 28 cases of lung-wei insecurity-type sweating syndrome in children. Tuina was carried out for once every other day, and moxibustion was conducted for once every other three days. Clinical efficacy was observed after treatment for 4 weeks. Results The total eff ective rate of tuina combined with moxibustion for treatment of lung-wei insecurity-type sweating syndrome in children was 92.85%. Conclusion The efficacy of tuina combined with moxibustion for treatment of lung-wei insecurity-type sweating syndrome in children is definite, which is worthy of being popularized clinically.
