期刊：
International Journal of Circuits, Systems and Signal Processing,2018年12:215-219 ISSN：1998-4464
通讯作者：
Hu, Zhigang(zghu@csu.edu.cn)
作者机构：
[Hu, Zhigang; He, Feng; Zhou, Yuanyuan] Software College, Central South University, Changsha, Hunan, 410075, China;[Liu, Wei] School of Management and Information Engineering, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China
通讯机构：
Software College, Central South University, Changsha, Hunan, China
关键词：
Evaluation function of the weight index;Medical insurance fraud;Outlier detection;Particle swarm optimization;Weighted k-means algorithm
作者：
A multi-factor influencing POI recommendation model based on matrix factorization
作者机构：
湖南大学
会议名称：
2018 Tenth International Conference on Advanced Computational Intelligence (ICACI)
会议时间：
2018-03-29到2018-03-31
会议地点：
厦门
关键词：
UHFRPPHQGDWLRQV\VWHP SRLQW RI LQWHUHVW 32, PDWUL[IDFWRUL]DWLRQ /%61
摘要：
How to make recommendation for personalized users by using the available sparse data is
a hot research topic in the area of big data and has wide application prospects. In this work,
we investigate the POI (Point of Interest) recommendation of LBSN (Location Based Social …
作者：
A steady-state NSGA-II based multi-objective multicast routing algorithm for optical networks
作者机构：
湖南大学
会议名称：
GECCO '18 Proceedings of the Genetic and Evolutionary Computation Conference
会议时间：
2018-07-15到2018-07-19
会议地点：
日本京都
关键词：
Multi-objective optimization, Multicast Routing and Wavelength Assignment, QoS
摘要：
Multicast routing for wavelength division multiplexing optical network is a challenging
problem in optical networks. The Multicast Routing and Wavelength Assignment (MRWA)
problem has been proved to be a NP complete problem. In this paper, the MRWA problem in …
摘要：
Due to the complex conditions on the roads, intelligent vehicles need to face infinite
environments. Based on the neighborhood control theory, the infinite world can be reduced
to a limited and irregular feasible area. By constructing a finite number of feasible …
摘要：
Despite chemotherapy has been widely used for tumor therapy, the serious side effect is still a major challenge. Recently, two dimensional nanomaterial-based drug delivery systems have attracted wide concern due to their high drug loading and low side effect. In addition, some kinds of nanomaterials can directly act as a photosensitizer to induce cancer destruction. In this study, we developed a drug delivery system of mixture of high/low molecular weight branched polyethylenimine-polyethylene glycol-reduced graphene oxide (mBPEI-PEG-rGO) using reduced graphene oxide as matrix. A model drug of doxorubicin (DOX) was loaded on the nanocomposites with the efficiency of 81% and the release rate of more than 50% at acidic environment. In vitro experiments indicated that mBPEI-PEG-rGO-DOX with enhanced stability and biocompatibility efficiently delivered and released DOX into cells mainly through micropinocytosis and killed SMMC-7721 cells by inducing reactive oxygen species (ROS) and cell apoptosis. Furthermore, in vivo experiments indicated that the combination of intratumoral injection of mBPEI-PEG-rGO-DOX and local laser irradiation nearly ablated hepatocarcinoma. In conclusion, this new drug delivery system provided an alternative for combinational photothermal and chemotherapy against hepatocarcinoma.
摘要：
As an essential phosphate group hydrolase, alkaline phosphatase (ALP), whose level in serum is correlated with bone disease, liver dysfunction, and cancer, could be used as a biomarker for clinical diagnosis and biomedical studies. Hence, developing a convenient and sensitive method for ALP assay has importance in disease diagnosis, drug treatment, and prognosis assessment. In this work, using a hairpin DNA strand as the substrate, we developed an ultrasensitive and simple fluorescence method for quantitative ALP assay based on the binding difference of reduced graphene oxide (rGO) with different DNA strands coupled with λ exonuclease (λ exo) cleavage. Under the optimal conditions, the limit of detection (LOD) of ALP is estimated to be 0.01 U/L with the linear region from 0.5 U/L to 70 U/L. Furthermore, the proposed assay was used to detect ALP in complicated cell-free extracts and evaluate the inhibitory effects of two well-known inhibitors of ALP activity. Finally, the method was used to investigate the effect of natural compounds on ALP activity and five compounds with different inhibitory capability were screened. In summary, we propose that the new method for ALP assay can be applied for therapeutic drug monitoring (TDM) and high-throughput compound screening in combination with multiwell plate technology.
作者机构：
[Jiang Bo] Yangtze Normal Univ, Chongqing Key Lab Characterist Plant Resource Pro, Chongqing 408100, Peoples R China.;[Huang Jian-hua; Jiang Bo] Hunan Acad Tradit Chinese Med, Inst Chinese Mat Med, Changsha 410013, Hunan, Peoples R China.;[Jiang Bo] Yangtze Normal Univ, Collaborat Innovat Ctr Green Dev Wuling Mt Areas, Chongqing 408100, Peoples R China.
通讯机构：
[Huang Jian-hua] H;Hunan Acad Tradit Chinese Med, Inst Chinese Mat Med, Changsha 410013, Hunan, Peoples R China.
关键词：
麻疯树油;电感耦合等离子体串联质谱;多元素;碰撞/反应池;反应气
摘要：
工业化和现代化进程的加快消耗了大量能源, 对能源的高度依赖性导致了全球化石能源需求的快速增长, 随着非再生化石能源的日渐枯竭, 迫切需要大力发展可再生能源以调整现有能源结构。 作为国际上研究最多的生物柴油, 麻疯树油是国内外公认的最有可能替代化石能源的再生能源, 具有极大的开发潜力。 麻疯树油中的微量元素在燃烧过程中会影响发动机的性能, 并在尾气排放过程中决定了对环境所造成的污染程度。 本文以获得麻疯树油中多元素的含量为目的, 建立应用电感耦合等离子体串联质谱(ICP-MS/MS)法准确测定麻疯树油中低水平Na, Si, P, S, Cl, K, Ti, V, As含量的分析方法。 采用微波密闭消解系统, 依次向麻疯树油样品中加入硝酸和双氧水进行消解。 详细地研究了各待测元素在不同分析模式下检出限(DL)和背景等效浓度(BEC)的变化情况, 在MS/MS模式下, 通过向碰撞/反应池(CRC)中加入反应气可以完全消除质谱干扰。 选择O2为反应气, P+, S+, Ti+, V+, As+与O2的反应均为放热过程, 能发生质量转移自发生成PO+, SO+, TiO+, VO+, AsO+, 利用O2质量转移法消除质谱干扰; 选择H2为反应气, Cl+与H2反应能自发生成ClH+2, 利用H2质量转移法消除质谱干扰, 而Na+, Si+, K+均不能与H2发生质量转移反应, 利用H2原位质量法消除质谱干扰。 选择Sc为内标元素校正了分析过程中的基体效应。 通过考察不同反应气流速下各元素的BEC变化, 优化了反应气流速, O2的最佳流速为0.45 mL·min-1, H2的最佳流速为7.5 mL·min-1。 在优化的实验条件下获得Na, Si, P, S, Cl, K, Ti, V, As的检出限分别为6.41, 37.3, 24.6, 118, 530, 7.96, 7.61, 0.34, 3.20 ng·L-1, 各元素在0～50 μg·L-1范围内的线性相关系数(R2)≥0.999 8, 方法具有良好的线性关系。 采用三水平加标回收实验来验证方法的准确性和精密度, 所有元素的加标回收率在91.2%～108%之间, 相对标准偏差(RSD)为1.9%～4.6%, 表明所建立的方法准确性好, 精密度高。 通过对来自中国不同地区的4个麻疯树油样品进行测定, 结果显示, 4个麻疯树油样品中P含量≤164 ng·g-1, S含量≤2310 ng·g-1, 碱(Na+K)含量≤1 690 ng·g-1, 三项指标均达到了中国生物柴油调和燃料国家标准, 欧Ⅳ生物柴油标准, 德国生物柴油标准和美国生物柴油标准。 这项研究为麻疯树油中多种微量元素的准确分析提供了一种方便可行的新方法, 为麻疯树油的质量控制和安全应用提供了科学的理论依据。 According to the development of industrialization and modernization, much more conventional fossil energy resource is excess consumed, with the depletion of non-renewable energy resource, the development of new renewable energy was urgently needed. As one of the hottest concerned biodiesel resources, Jatropha curcas L. oil was thought as the most possible renewable energy to replace conventional fossil energy resource. The trace elements in Jatropha oil might affect the performance of engine, and deteriorate environment. In order to obtain the contents of multi-elements in Jatropha curcas L. oil, an analytical method was established for accurately determination of Si, P, S, Cr and As in Jatropha curcas L. oil by using inductively coupled plasma tandem mass spectrometry (ICP-MS/MS). Jatropha oil was processed by using microwave-assisted acid-digested reaction with nitric acid and hydrogen peroxide. The changes of detection limit (DL) and background equivalent concentration (BEC) for multi-elements in different analysis modes were optimized in detail. In the MS/MS mode, O2 was introduced into the collision reaction cell (CRC), then Si+, P+, S+, Cr+ and As+ were reacted with O2 to generate SiO+2, PO+, SO+, CrO+ and AsO+ respectively; thus mass spectrometry interference can be eliminated by mass shift caused by reactions. As Cl+ can reaction with H2 to form ClH+2, while Na+, Si+, K+ elements cannot reaction with it, the mass shift caused by reaction with H2 was selected to eliminate mass spectrum interference. Sc was selected as internal standard element to correct the matrix effects. The flow rates in the CRC of different reaction gas were optimized by considering the background equivalent concentration (BEC) of analytes, and the best gas flow rate for O2 and H2 were 0.45 mL·min-1, and 7.5 mL·min-1, respectively. The DL for Na, Si, P, S, Cl, K, Ti, V, and As were 6.41, 37.3, 24.6, 118, 530, 7.96, 7.61, 0.34, and 3.20 ng·L-1, respectively, under the optimized conditions. The linear correlation coefficient (R2) of analytes were ≥0.999 8 in the range 0～50 μg·L-1. The recovery of all elements ranged from 91.2% to 108%, and the relative standard deviation (RSD) was ranged from 1.9% to 4.6%. These results showed that the proposed method was accuracy and precise. Analytical results obtained from different original Jatropha curcas L. oil showed that the contents of element P, S, and (Na+K) were ≤164, 2 310, and 1 690 ng·g-1, respectively. These indexes were much lower than those of the contents in the conventional fossil energy resource, and reached the standards of Chinese national standard of biodiesel, European IV biodiesel standard, German biodiesel standard, and American biodiesel standard. This study proposed a new approach for the determination of multi-element in Jatropha curcas L. oil with convenience and feasibility, and provided a scientific basis for the quality control and safety application of Jatropha curcas L. oil.
摘要：
Considering the increasingly large scale of gene expression data, common module
identification algorithms exist many problems, such as large search space and long running
time. A novel co-regulatory modules identification algorithm RMCL-ESA (Regularized …
关键词：
reactive power planning;distributed generation;active power adjustment;mixed integer nonlinear programming
摘要：
To deal with extreme overvoltage scenarios with small probabilities in regional power grids, the traditional reactive power planning model requires a huge VAR compensator investment. Obviously, such a decision that makes a large investment to cope with a small probability event is not economic. Therefore, based on the scenario analysis of power outputs of distributed generations and load consumption, a novel reactive power planning model considering the active and reactive power adjustments of distributed generations is proposed to derive the optimal allocation of VAR compensators and ensure bus voltages within an acceptable range under extreme overvoltage scenarios. The objective of the proposed reactive power planning model is to minimize the VAR compensator investment cost and active power adjustment cost of distributed generations. Moreover, since the proposed reactive power planning model is formulated as a mixed-integer nonlinear programming problem, a primal-dual interior point method-based particle swarm optimization algorithm is developed to effectively solve the proposed model. Simulation results were conducted with the modified IEEE 30-bus system to verify the effectiveness of the proposed reactive power planning model.
通讯机构：
[Zhou, YJ; Deng, X] C;Cent S Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China.
摘要：
A CuII-catalyzed radical annulation/C3-functionalization cascade of tryptamine derivatives with aryl ethylene is reported. The mild catalytic system enables the facile construction of 3a-benzoylmethylpyrrolidino[2,3-b]indolines with excellent chemo- and regioselectivities. Remarkably, this novel method utilizes earth-abundant and inexpensive cupric salt as the catalyst and air as the co-oxidant, rendering the process highly environmentally friendly and atom economic. Presumably, the reaction proceeds through CuII-initiated formation of pyrrolidino[2,3-b]indolines radical intermediate I, which is successively trapped by aryl ethylene and O2 to form the product. An 18O2-labeling experiment and several control experiments were designed to support the mechanistic proposal.
摘要：
As is well-known, microRNAs (miRNAs), a short nor-coding RNA, play a vital role in
important biological processes such as gene expression and transcriptional regulation. And
it was reported that miRNAs have involved in the occurrence and development of various …
摘要：
One of the key challenges in bioinformatics is to find the distinction between driver mutations that lead to tumorigenesis and random passenger mutations, which are known to be neutral and does not play any role in cancer development. To solve this problem, several approaches and techniques were used. In this article, we introduce an algorithm based on an exact approach in order to solve the so called “maximum weight submatrix problem”. The proposed algorithm maximizes the weight and samples all the possible pathways that can be found. We present the details about our algorithm and then compare them to a metaheuristic algorithm called Genetic Algorithm (GA) and with another exact model named Binary Linear Programming (BLP). Our Exact Algorithm shows good results in terms of maximizing the weight and finding all possible pathways.
作者机构：
[Wang, Chao; Dong, Pei-Pei; Deng, Sa; Tian, Xiang-Ge; Huo, Xiao-Kui; Sun, Cheng-Peng; Zhang, Bao-Jing; Ma, Xiao-Chi] Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Coll Pharm, Dalian 116044, Peoples R China.;[Li, Bin; Wang, Wei] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.
通讯机构：
[Ma, Xiao-Chi] D;[Wang, Wei] H;Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Coll Pharm, Dalian 116044, Peoples R China.;Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.
关键词：
Alcoholic hydroxyls;Glucosylation;Protostane triterpenoid;Syncephalastrum racemosum AS 3.264
摘要：
An efficient glucosylation of alcoholic hydroxyls in the structures of protostane triterpenoids catalyzed by fungus has been developed. Four protostanes 1–4 as the substrates have been transformed by Syncephalastrum racemosum AS 3.264 and generated corresponding 11-OH glucosylation derivatives. The regioselective characteristics were also identified by various highly oxygenated protostane substrates. The time-courses displayed the highest yields of 1a, 3a, and 4a at > 50%, and 1a had the highest yield of 72%. All of the protostane analogues displayed hCE-2 inhibitory effects in an in vitro bioassay. This report describes a rare biocatalytic alcoholic hydroxyl glucosylation with considerable yield and regioselective characteristics.
