期刊:
International Journal of Analytical Chemistry,2023年2023 ISSN:1687-8760
通讯作者:
He, Yongheng(2320990685@qq.com)
作者机构:
[Yao, Yanru; Ding, Ning; Luo, Hongbiao; Zhang, Tao] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.;[Luo, Hongbiao] Chenzhou 1 Peoples Hosp, Dept Anorectal Surg, Chenzhou 423000, Peoples R China.;[Peng, Tianshu] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Anorectal Surg, Changsha 410005, Hunan, Peoples R China.;[He, Yongheng] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Anorectal Surg, Changsha 410006, Hunan, Peoples R China.
通讯机构:
[Hongbiao Luo; Ning Ding; Yanru Yao; Tao Zhang] H;[Yongheng He; Tianshu Peng] D;Department of Anorectal Surgery,The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine,Changsha,China<&wdkj&>Department of Anorectal Surgery,The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,China<&wdkj&>Hunan University of Chinese Medicine,Changsha,Hunan 410208,China<&wdkj&>Department of Anorectal Surgery,Chenzhou NO. 1 People’s Hospital,Chenzhou 423000,China<&wdkj&>Hunan University of Chinese Medicine,Changsha,Hunan 410208,China
关键词:
Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles
期刊:
Computational and Mathematical Methods in Medicine,2023年2023 ISSN:1748-6718
通讯作者:
Dayuan, Zhong(13751728424@163.com)
作者机构:
[Dayuan, Zhong; Hui, Cheng; Yumiao, Luo; Deliang, Liu] Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan;528200, China;[Lan, Li; Dingxiang, Li; Yihui, Deng] Hunan University of Traditional Chinese Medicine, Changsha;410208, China;[Huanjie, Li] Foshan Hospital of Traditional Chinese Medicine, Foshan
通讯机构:
[Dayuan, Z.] G;Guangdong Provincial Hospital of Integrated Traditional Chinese and Western MedicineChina
作者机构:
[Cai Song-tao] Hunan Inst Technol, Coll Mat Sci & Engn, Hengyang 421002, Peoples R China.;[Xie Hua-lin] Yangtze Normal Univ, Coll Chem & Chem Engn, Chongqing 408100, Peoples R China.;[Huang Jian-hua] Hunan Acad Tradit Chinese Med, Inst Chinese Mat Med, Changsha 410013, Peoples R China.
通讯机构:
[Huang, J.-H.] I;Institute of Chinese Materia Medica, China
关键词:
谷类辅助食品;婴幼儿;电感耦合等离子体串联质谱;反应模式
摘要:
婴幼儿谷类辅助食品是婴幼儿营养的重要能量来源, 其主要原料为大米, 而水稻极易从其生长的土壤和水中吸收重金属Cd积累到谷粒中, 导致大米中Cd的残留浓度相对较高, 从而对婴幼儿谷类辅助食品构成潜在威胁。 提出了电感耦合等离子体串联质谱(ICP-MS/MS)测定婴幼儿谷类辅助食品中重金属Cd的新策略。 样品经微波消解处理后, 采用ICP-MS/MS进行测定。 婴幼儿谷类辅助食品中Cd的测定所面临的质谱干扰主要来源于高浓度Mo所形成的Mo基多原子干扰离子(MoO+, MoN+, MoC+)以及Sn所形成的同量异位素(112Sn+, 114Sn+, 116Sn+)。 针对这些干扰, 在MS/MS模式下, 分别采用H2, NH3/He和O2为反应气, 考察不同Cd同位素的质谱干扰消除效果和分析灵敏度。 结果表明, 在H2和NH3/He反应模式下, H2和NH3均能与Mo基干扰离子发生质量转移反应, 而不与Sn+反应, 可选择110Cd+, 111Cd+和113Cd+进行测定, 但H2与Mo基干扰离子反应速度较慢, 难以彻底消除高浓度Mo基质中对Cd的质谱干扰; 在O2反应模式下, 所有干扰离子均能与O2发生质量转移反应, 虽然获得的分析灵敏度略低于NH3/He反应模式, 但背景等效浓度(BEC)明显比NH3/He反应模式低。 确定了以O2为反应气消除干扰测定Cd的最优分析方案。 利用标准参考物质评价了方法的准确性, 采用国标法(GB5009.268—2016)进行对比分析验证了方法的可靠性。 结果表明, Cd的LOD为2.03~13.4 ng·L-1, 标准参考物质的测定值与认定值基本一致, 在95%的置信水平, 对比分析结果之间无显著性差异。 方法的灵敏度高, 结果准确可靠, 适用于大批量婴幼儿谷类辅助食品中重金属Cd的高通量测定。 Cereal-based complementary food for infants and young children is an important energy source for infants and young children nutrition. The main raw material for the cereal-based complementary food is rice. While, rice can easily absorb heavy metal Cd from the soil and water in growing process, result in a relatively high residual concentration of Cd in rice, and posing a potential threat. In this paper, a new strategy for determination of heavy metal Cd in cereal-based complementary food for infants and young children by inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) was proposed. The sample was directly determined by ICP-MS/MS after microwave digestion. The main spectral interferences in the determination process were Mo based polyatomic interference ions (MoO+, MoN+, MoC+) formed by high concentration Mo, and isobar (112Sn+, 114Sn+, 116Sn+) formed by Sn. In order to eliminate these interferences, in the MS/MS mode, using H2, NH3/He, and O2 as reaction gas, the interference elimination effect and analysis sensitivity of different Cd isotopes were investigated. The results show that in the H2 and NH3/He reaction mode, both H2 and NH3 can undergo mass shift reaction with Mo-based interfering ions, but cannot react with Sn+. 110Cd+, 111Cd+, 113Cd+ can be selected for determination. However, the reaction speed of H2 and Mo-based interfering ions is slow, and it is difficult to completely eliminate the mass spectral interference of Cd in high-concentration Mo-based matrix. In the O2 reaction mode, all interfering ions can undergo mass shift reaction with O2. Although the analytical sensitivity obtained is slightly lower than that in the NH3/He reaction mode, the background equivalent concentration (BEC) is significantly lower than that in the NH3/He reaction mode. The optimal analysis scheme for eliminating the interference in the determination of Cd with O2 as the reaction gas was determined. The accuracy of the method was evaluated by using standard reference materials, and the reliability of the method was verified by comparative analysis with the national standard method (GB5009.268—2016). The results showed that the LOD of Cd is 2.03~13.4 ng·L-1, and the measured value of the standard reference materials is basically the same as the certified value. At the 95% confidence level, there is no significant difference between the comparative analysis results. The method has high sensitivity, accurate and reliable results, and is suitable for the high-throughput determination of heavy metal Cd in large quantities of cereal-based complementary food for infants and young children.
作者机构:
[Li Ai-yang] Hunan Inst Technol, Coll Mat & Chem Engn, Hengyang 421002, Peoples R China.;[Fu Liang] Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400045, Peoples R China.;[Chen Lin] Hunan Acad Tradit Chinese Med, Inst Chinese Mat Med, Changsha 410013, Peoples R China.
通讯机构:
[Fu, L ] C;Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400045, Peoples R China.
关键词:
植物精油;电感耦合等离子体发射光谱;重金属;多模式样品导入系统;快速自动曲线拟合技术
摘要:
植物精油是从芳香植物提取的天然复杂化合物, 作为芳香植物的次生代谢产物具有挥发性和浓郁香味, 其特有的多样化生物活性广泛应用于医药和化妆品行业。 植物精油具有高渗透性, 能以活跃的分子态渗透皮肤组织, 经淋巴腺吸收后进入血液, 其所含的重金属元素也极易随植物精油进入人体对健康构成潜在威胁。 采用硝酸-双氧水对植物精油进行微波消解, 在多模式样品导入系统(MSIS)的双重模式下, 采用电感耦合等离子体发射光谱(ICP-OES)测定其中可形成蒸气重金属元素As, Sn, Sb, Hg和不可形成蒸气重金属元素Cr, Ni, Cd和Pb的含量。 选择盐酸对样品进行酸化并预还原氧化态元素, 通过在线加入L-半胱氨酸/酒石酸提高可形成蒸气元素的蒸气发生效率, 利用硼氢化钠/氢氧化钠在MSIS中将As, Sn, Sb和Hg转变为蒸气状态; 针对分析过程中存在的多个或单个光谱重叠和背景干扰, 分别对空白溶液、 分析元素和预期干扰元素的纯溶液进行测定, 根据获得的光谱响应数据解卷积构建快速自动曲线拟合技术(FACT)模型, 将分析谱线从干扰谱线中分离出来, 从而实现光谱重叠干扰和背景干扰的实时校正; 采用加标回收并与电感耦合等离子体质谱(ICP-MS)进行对比分析评价方法的准确性。 各元素方法的检出限(MDL)为0.3811.2 μg·kg-1, 加标回收率为95.4%104%, 相对标准偏差(RSD)为1.9%4.9%, 对比分析的相对误差(RE)在-2.1%2.7%之间, 表明方法准确可靠, 精密度高。 对8种植物精油中的重金属元素进行了分析, 所有植物精油样品中重金属元素As, Hg和Pb的含量远低于GB/T 26516-2011制定的限量标准, 植物精油中重金属元素Cr, Ni, Sn, Cd和Sb的含量虽然没有制定限量标准, 但均处于极低水平。 MSIS兼具传统雾化和蒸气发生双重功能, 在分析可形成蒸气元素和不可形成蒸气元素时无需切换不同进样系统, 能满足大批量植物精油中微量重金属元素的高通量分析需要。 Plant essential oils are naturally complex compounds extracted from aromatic plants with volatile and tangy aromas as secondary metabolites of aromatic plants, and their diverse biological activities are widely used in the pharmaceutical and cosmetic industries. Plant essential oils are highly permeable and can penetrate skin tissue in an active molecular state and enter the bloodstream after absorption via the lymph glands. The heavy metal elements they contain are also highly susceptible to the entry of plant essential oils into the human body, posing a potential threat to health. This paper used nitric acid and hydrogen peroxide for microwave digestion of plant essential oils. In the dual-mode of multimode sample introduction system (MSIS), the contents of vapor forming heavy metal elements As, Sn, Sb, and Hg and non-vapor forming heavy metal elements Cr, Ni, Cd, and Pb were determined by inductively coupled plasma optical emission spectrometry (ICP-OES). Hydrochloric acid was selected to acidify the sample and reduce the oxidized analytes in the sample. L-cysteine/tartaric acid was added online to improve the vapor generation efficiency. Sodium borohydride/sodium hydroxide was selected to transform As, Sn, Sb, and Hg into the vapor state in MSIS. Because of the multiple or single spectral overlap and background interference in the analysis process, the pure solutions for the blank, analyte and the expected interferences are measured in the sample, and the fast automatic curve fitting technology (FACT) was constructed according to the obtained spectral response data by deconvolution. Analytical spectral lines were separated from interference spectral lines to realize real-time correction of spectral overlap interference and background interference. The method’s accuracy was evaluated by the spike recovery experiments and comparison with inductively coupled plasma mass spectrometry (ICP-MS). The method detection limit (MDL) of analyte was between 0.38~11.2 μg·kg-1, the spiked recovery was 95.4%~104%, the relative standard deviation (RSD) was 1.9%~4.9%, and the relative error (RE) of the comparative analysis ranged from -2.1% to 2.7%, indicating that the method was accurate and reliable with high precision. The heavy metal elements in eight plant essential oils were analyzed, and the levels of As, Hg, and Pb in all plant essential oil samples were well below the maximum limit standards established by GB/T 26516-2011, while the levels of Cr, Ni, Sn, Cd, and Sb, the heavy metal elements in plant essential oils, although no limit standards were established, were at extremely low levels. MSIS has the dual functions of traditional atomization and vapor generation. It does not need to switch different sampling systems when analyzing vapor forming elements and non-vapor forming elements. It can meet the needs of high-throughput analysis of trace heavy metal elements in large quantities of plant essential oils.
作者机构:
[Zhu, Liangdi; Zhou, Yuxing; Cheng, Xunlong; Zhu, Xixi] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China;[Fei, Lingyun] Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China;[Deng, Lanqing] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China. Electronic address: denglq1111@126.com;[Ma, Xin] Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China. Electronic address: maxin2013@csu.edu.cn
通讯机构:
[Lanqing Deng] C;[Xin Ma] H;Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China<&wdkj&>College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China
期刊:
Computational and Mathematical Methods in Medicine,2022年2022 ISSN:1748-6718
通讯作者:
Zhu, Zhenhua(202013000604@hceb.edu.cn)
作者机构:
[Zhu, Zhenhua; Wu, Qi; Hu, Ge; Wang, Xianwen; Chang, Wei; Bin, Ji; Yang, Weili] Otolaryngology-Wide Head and Neck Surgery Department, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Hunan, Changsha;410007, China;[Zhu, Zhenhua; Wu, Qi; Hu, Ge; Wang, Xianwen; Chang, Wei; Bin, Ji; Yang, Weili] 410007, China
通讯机构:
[Zhu, Z.] O;Otolaryngology-Wide Head and Neck Surgery Department, Hunan, China
作者机构:
[Liao, Zhibing; Yao, Liu; Liu, Yan; Wu, Yaohui; Wang, Yonghong] Hunan Provincial Key Laboratory for Forestry Biotechnology & International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology, Central South University of Forestry and Technology, Changsha;410004, China;[Ning, Ge] International Education Institute, Hunan University of Chinese Medicine, Changsha;410208, China;[Liao, Zhibing; Yao, Liu; Liu, Yan; Wu, Yaohui; Wang, Yonghong] 410004, China
通讯机构:
[Yonghong Wang] H;[Ge Ning] I;Hunan Provincial Key Laboratory for Forestry Biotechnology & International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology, Central South University of Forestry and Technology, 410004, Changsha, China<&wdkj&>International Education Institute, Hunan University of Chinese Medicine, 410208, Changsha, China
作者机构:
[林艳; 夏伯候; 林丽美; 李亚梅] Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Changsha;410208, China;[李春] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing;100700, China;[林艳; 夏伯候; 林丽美; 李亚梅] 410208, China
通讯机构:
[Li, Y.-M.] K;Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan ProvinceChina
关键词:
中红外光谱;生首乌;制首乌;模式识别;二苯乙烯苷
摘要:
何首乌有生首乌和制首乌之分, 生首乌能解毒, 润肠通便; 制首乌能补肝肾, 益精血, 乌须发, 强筋骨, 化浊降脂。 生/制首乌都含有二苯乙烯苷类、 蒽醌类、 磷脂类等化学成分, 但其含量存在一定差异。 生首乌炮制后其毒性减弱。 生/制首乌的功效、 主治和毒性都存在一定的差异, 在外观性状上差异较易识别, 但其磨成粉末后两者不易区分。 因此, 寻找一种快速简单的判别方法来区分生/制首乌十分必要。 中红外光谱法具有检测速度快, 对样品无损等优势, 已在中药质量控制和鉴别中得到广泛的应用。 该研究建立生/制首乌中红外光谱的指纹图谱, 并采用正交偏最小二乘-判别分析对其进行鉴别。 在4 000~700 cm-1范围内采集38批不同来源生/制首乌中红外光谱数据, 分析其主要的特征峰, 并用simca13.0软件对数据进行正交偏最小二乘-判别分析。 建立38批不同来源生/制首乌中红外指纹图谱, 并分析出主要化学成分包括蛋白质类、 核酸类、 脂肪酸类、 蒽醌类、 二苯乙烯苷类、 磷脂类。 对红外光谱峰形和峰强度进行分析, 生首乌和制首乌的峰形差异比较少, 但峰强度具有一定的差异。 为了建立生/制首乌红外光谱差异模型, 采用正交偏最小二乘-判别分析法, 其结果能很好地将生/制首乌分成两类, 左边为制首乌, 右边为生首乌。 根据变量在项目中的重要性(VIP值)筛选差异化学成分, 并利用SPSS17.0统计软件进行t检验, 以VIP>1及p<0.05确定差异性化学成分。 生/制首乌的差异性化学成分为二苯乙烯苷类、 蒽醌类、 磷脂类, 表明何首乌炮制后二苯乙烯苷类、 蒽醌类、 磷脂类的含量都发生变化。 中红外光谱结合模式识别筛选出差异性化学成分和文献报道基本一致, 表明此法可用于生/制首乌鉴别。 本研究成功采用中红外光谱对生/制首乌进行快速检测和整体质量评价, 结合模式识别能将其鉴别, 可为中药质量控制和快速鉴别提供依据。 The roots of Polygonum multiflorum are traditional Chinese medicinal herbs in processed form or raw state. Raw Polygonum multiflorum can detoxify and loosen the bowel and relieves constipation, but processed Polygonum multiflorum can benefit blood, hair, strong muscles and bones, turbidness and lipid lowering. The raw and processed Polygonum multiflorum contain chemical components such as stilbene glycosides, anthraquinone and phospholipid, but their contents are different. The toxicity of raw Polygonum multiflorum decreased after processing. The chemical composition, efficacy and hepatotoxicity of raw and processed Polygonum multiflorum are different. It was easy to recognize the difference in appearance between raw and processed Polygonum multiflorum, but it was not easy to distinguish the power of raw and processed Polygonum multiflorum. Therefore, it is necessary to find a fast and simple method for distinguishing them. Mid-IR has the advantages of fast detection speed and nondestructive. Mid-IR has been widely used in the identification of traditional Chinese medicine. This paper aimsf to establish the fingerprint of the mid-infrared spectrum of raw and processed Polygonum multiflorum and identify them by orthogonal partial least-squares discriminant analysis (OPLS-DA). The chemical composition in 38 batches of raw and processed Polygonum multiflorum were determined by mid-IR of 4 000~700 cm-1, and the characteristic peaks of chemical composition were analyzed. OPLS-DA of simca13.0 software analyzed the data. The mid-infrared fingerprints of 38 batches of polygonum multiflorum from different sources were established, mainly including protein, nucleic acid, fatty acid, anthraquinone, stilbene glycosides and phospholipids. The peak shape and peak intensity of the infrared spectrum were analyzed, and the difference of peak shape between the raw and the processed radix aconitum was less, but the peak strength was different. OPLS-DA was used to establish the infrared spectral difference model of raw/processed Polygonum multiflorum. The results showed that the raw and processed Polygonum multiflorum could be well divided into two categories. The left was raw Polygonum multiflorum, and the right was processed Polygonum multiflorum. SPSS 13.0 statistical software was used to perform the t-test. Constituents with VIP>1 and p<0.05 (t-test) were considered statistically significant. The differential constituents of raw and processed Polygonum multiflorum were stilbene glycosides, anthraquinone and phospholipid. The results showed that the content of stilbene glycosides, anthraquinone and phospholipid were different in the raw and processed Polygonum multiflorum. The differential constituents of raw and processed Polygonum multiflorum found by mid-IR and pattern recognition is consistent with the literature reports. The results showed that this method was feasible. In this study, the medium infrared spectrum was successfully used for the rapid detection and overall quality evaluation of Polygonum multiflorum. Identifying Polygonum multiflorum with Mid-IR and pattern recognition could provide the basis for the quality control and rapid identification of Traditional Chinese medicine. The study can successfully identify theraw and processed Polygonum multiflorum by mid-IR and pattern recognition and provide a reference for quality control and quick identification of TCM.
作者机构:
[Xie, Hualin; Fu, Liang] Yangtze Normal Univ, Coll Mat Sci & Engn, Fuling 408100, Peoples R China.;[Chen, Lin; Huang, Jianhua] Hunan Acad Tradit Chinese Med, Inst Chinese Mat Medica, Changsha 410013, Peoples R China.;[Chen, Lin; Huang, Jianhua] Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha 410208, Hunan, Peoples R China.;[Xie, Hualin] Yangtze Normal Univ, Coll Mat Sci & Engn, 16 Juxian Rd, Chongqing 408100, Peoples R China.
通讯机构:
[Xie, Hualin] Y;Yangtze Normal Univ, Coll Mat Sci & Engn, 16 Juxian Rd, Chongqing 408100, Peoples R China.
关键词:
Hepatocellular carcinoma;Inductively coupled plasma tandem mass spectrometry;N(2)O;Serum;Trace elements
摘要:
The occurrence and development of hepatocellular carcinoma (HCC) is related to the level of trace elements. The mechanism of changes in trace element concentration and the identification of HCC risks associated with them are not clear. Therefore, an accurate and reliable approach for quantification of the level of trace elements in the serum of liver cancer patients is of great significance. In this study, we proposed a novel strategy for accurate determination of trace elements such as Mn, Fe, Ni, Cu, Zn, and Se in the serum of HCC patients based on inductively coupled plasma tandem mass spectrometry (ICP-MS/MS). In the MS/MS mode, N2O was used as the reaction gas, and an octopole reaction system (ORS) was employed to provide interference-free conditions and a sufficiently low limit of detection (LOD) for the determination of analytical elements. The internal standard elements with similar masses and similar mass spectrometry behavior were selected to correct the matrix effect. The LODs of Mn, Fe, Ni, Cu, Zn, and Se were as low as 0.013, 0.25, 0.010, 0.020, 0.17, and 0.008 mu g L-1, respectively. Bovine serum (SRM 1598a) was adopted as the standard reference material to evaluate the accuracy of the method, and the developed method was successfully applied to determine the content of Mn, Fe, Cu, Zn, Ni, Se in serum from HCC patients. The obtained results were in agreement with that of sector field ICP-MS (SF- ICP-MS). The contents of Fe and Cu in the serum of HCC patients were higher compared to that of healthy controls, while the contents of Zn and Se were lower than that of healthy controls. Furthermore, no significant differences were observed in the contents of Mn and Ni in the serum of HCC patients and healthy controls. (C) 2020 Elsevier B.V. All rights reserved.
摘要:
Computational drug repositioning helps to decipher the complex relations among drugs,
targets, and diseases at a system level. However, most existing computational methods are
biased towards known drugs-disease associations already verified by biological …
作者机构:
[陈珂珂; 唐亮; 贺气志; 罗怀青; 徐倩] School of Basic Medical Science, Changsha Medical University, Changsha, 410219, China;[宁毅] The Medicine School of Hunan University of Chinese Medicine, Changsha, 410208, China
通讯机构:
The Medicine School of Hunan University of Chinese Medicine, Changsha, China
期刊:
International Journal of Circuits, Systems and Signal Processing,2018年12:215-219 ISSN:1998-4464
通讯作者:
Hu, Zhigang(zghu@csu.edu.cn)
作者机构:
[Hu, Zhigang; He, Feng; Zhou, Yuanyuan] Software College, Central South University, Changsha, Hunan, 410075, China;[Liu, Wei] School of Management and Information Engineering, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China
通讯机构:
Software College, Central South University, Changsha, Hunan, China
关键词:
Evaluation function of the weight index;Medical insurance fraud;Outlier detection;Particle swarm optimization;Weighted k-means algorithm